IN2014MN02555A - - Google Patents

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Publication number
IN2014MN02555A
IN2014MN02555A IN2555MUN2014A IN2014MN02555A IN 2014MN02555 A IN2014MN02555 A IN 2014MN02555A IN 2555MUN2014 A IN2555MUN2014 A IN 2555MUN2014A IN 2014MN02555 A IN2014MN02555 A IN 2014MN02555A
Authority
IN
India
Prior art keywords
well
bottom plate
interest
single cells
individual
Prior art date
Application number
Inventor
Arjan Gerhardus Johannes Tibbe
Cornelis Johannes Maria Van Rijn
Leonardus Wendelinus Mathias Marie Terstappen
Original Assignee
Vycap B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NL1039638A external-priority patent/NL1039638C2/en
Priority claimed from NL1040089A external-priority patent/NL1040089C2/en
Application filed by Vycap B V filed Critical Vycap B V
Publication of IN2014MN02555A publication Critical patent/IN2014MN02555A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/08—Flat membrane modules
    • B01D63/088—Microfluidic devices comprising semi-permeable flat membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0039—Inorganic membrane manufacture
    • B01D67/0053—Inorganic membrane manufacture by inducing porosity into non porous precursor membranes
    • B01D67/006—Inorganic membrane manufacture by inducing porosity into non porous precursor membranes by elimination of segments of the precursor, e.g. nucleation-track membranes, lithography or laser methods
    • B01D67/0062—Inorganic membrane manufacture by inducing porosity into non porous precursor membranes by elimination of segments of the precursor, e.g. nucleation-track membranes, lithography or laser methods by micromachining techniques, e.g. using masking and etching steps, photolithography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/02—Inorganic material
    • B01D71/0215—Silicon carbide; Silicon nitride; Silicon oxycarbide
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/069—Absorbents; Gels to retain a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G01N2001/2873—Cutting or cleaving
    • G01N2001/288—Filter punches

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Inorganic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Dispersion Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

A micro well plate is described for capturing and distributing single cells in individual wells is described wherein at least one individual well is provided with a bottom plate having at least one pore to pass sample liquid such that if one object or cell of interest is collected on the bottom plate of the well the sample flow rate through that particular well is significantly reduced minimizing the possibility that multiple cells or objects of interest entering the same well. The presented invention is particularly suited for obtaining single cells and/or microorganisms suspended in fluid samples for subsequent detailed interrogation.
IN2555MUN2014 2012-06-01 2013-05-29 IN2014MN02555A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL1039638A NL1039638C2 (en) 2012-06-01 2012-06-01 Diagnostic device with a filtration membrane for on spot microscopic diagnostic analysis and methods.
NL1040089A NL1040089C2 (en) 2013-03-12 2013-03-12 Micro well plate to distribute single cells in single wells, and methods to use such plate.
PCT/NL2013/050389 WO2013180567A2 (en) 2012-06-01 2013-05-29 A microsieve diagnostic device in the isolation and analysis of single cells

Publications (1)

Publication Number Publication Date
IN2014MN02555A true IN2014MN02555A (en) 2015-07-24

Family

ID=48672779

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2555MUN2014 IN2014MN02555A (en) 2012-06-01 2013-05-29

Country Status (4)

Country Link
US (1) US9638636B2 (en)
EP (2) EP3725409A1 (en)
IN (1) IN2014MN02555A (en)
WO (1) WO2013180567A2 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013019491A1 (en) 2011-08-01 2013-02-07 Denovo Sciences Cell capture system and method of use
US9404864B2 (en) 2013-03-13 2016-08-02 Denovo Sciences, Inc. System for imaging captured cells
US10466160B2 (en) 2011-08-01 2019-11-05 Celsee Diagnostics, Inc. System and method for retrieving and analyzing particles
US10816550B2 (en) 2012-10-15 2020-10-27 Nanocellect Biomedical, Inc. Systems, apparatus, and methods for sorting particles
US9707562B2 (en) 2013-03-13 2017-07-18 Denovo Sciences, Inc. System for capturing and analyzing cells
US10391490B2 (en) 2013-05-31 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
WO2015118551A1 (en) * 2014-02-10 2015-08-13 Technion Research & Development Foundation Limited. Method and apparatus for cell isolation, growth, replication, manipulation, and analysis
JP2017518752A (en) 2014-06-12 2017-07-13 ウエハージェン インコーポレイテッド Single cell capture using a capture polymer membrane
US9757707B2 (en) 2014-06-12 2017-09-12 Takara Bio Usa, Inc. Single cell capture with capture chips
GB201501907D0 (en) * 2015-02-05 2015-03-25 Technion Res & Dev Foundation System and method for single cell genetic analysis
AU2016297895B2 (en) * 2015-07-24 2021-04-22 Novel Microdevices, Inc. Sample extraction device and methods of use thereof
JP7129909B2 (en) * 2016-02-18 2022-09-02 オプトフルイディクス インコーポレイテッド Systems and methods for characterizing particles in fluid samples
US11035795B2 (en) 2016-02-18 2021-06-15 Optofluidics, Inc. Methods for identification of particles in a fluid sample
EP3472351B1 (en) 2016-06-15 2020-10-28 Ludwig-Maximilians-Universität München Single molecule detection or quantification using dna nanotechnology
ES2860474T3 (en) 2016-12-12 2021-10-05 Minq Solutions B V A procedure for conducting an assay
US20200016591A1 (en) 2016-12-15 2020-01-16 University Of Twente A Molecule Printing Device for the Analysis of the Secretome of Single Cells
EP3609619A1 (en) 2017-04-14 2020-02-19 University Of Twente Device and method for the continuous trapping of circulating tumor cells
US10391493B2 (en) 2017-08-29 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
KR102056938B1 (en) * 2018-01-26 2019-12-17 (주)메타포어 Membrane structure with matrix structure and biomolecule filter using the same
JP7045924B2 (en) 2018-05-11 2022-04-01 東京応化工業株式会社 Cell capture filter membrane and its use
US11161066B2 (en) 2018-09-13 2021-11-02 International Business Machines Corporation Micro-machined filter for magnetic particles
WO2020090856A1 (en) 2018-11-02 2020-05-07 東京応化工業株式会社 Particle capturing device and particle capturing method
KR102224065B1 (en) * 2018-12-28 2021-03-05 포항공과대학교 산학협력단 Porous microwell and membrane with the porous microwell, and method for manufacturing the same
DE102019101389B4 (en) 2019-01-21 2020-08-06 Bruker Daltonik Gmbh Process for sample preparation on a spectrometric sample carrier
US10633693B1 (en) 2019-04-16 2020-04-28 Celsee Diagnostics, Inc. System and method for leakage control in a particle capture system
US11273439B2 (en) 2019-05-07 2022-03-15 Bio-Rad Laboratories, Inc. System and method for target material retrieval from microwells
SG11202112151UA (en) * 2019-05-07 2021-12-30 Bio Rad Laboratories System and method for automated single cell processing
US11724256B2 (en) 2019-06-14 2023-08-15 Bio-Rad Laboratories, Inc. System and method for automated single cell processing and analyses
US11767498B2 (en) * 2019-08-28 2023-09-26 Massachusetts Institute Of Technology In vitro tissue plate
WO2024011205A1 (en) * 2022-07-08 2024-01-11 Allegheny Singer Research Institute Devices and methods for separating cells or cell fragments

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4849077A (en) * 1984-08-06 1989-07-18 Akademie Der Wissenschaften Der Ddr Process for solid phase-sequencing of nucleic acid fragments
AU3752195A (en) * 1994-10-07 1996-05-02 Flinders Technologies Pty Ltd Apparatus and method for storage, purification or reaction and processing of a biopolymer
US20040053322A1 (en) * 2000-01-31 2004-03-18 Mcdevitt John T. System and method for the analysis of bodily fluids
US20060029955A1 (en) * 2001-03-24 2006-02-09 Antonio Guia High-density ion transport measurement biochip devices and methods
US20050009004A1 (en) * 2002-05-04 2005-01-13 Jia Xu Apparatus including ion transport detecting structures and methods of use
US7718442B2 (en) * 2002-11-22 2010-05-18 Genvault Corporation Sealed sample storage element system and method
US7597936B2 (en) * 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
US7501279B2 (en) * 2003-04-03 2009-03-10 University Of Washington Microwell arrays with nanoholes
AU2004235238A1 (en) * 2003-04-25 2004-11-11 Jsr Corporation Biochip and biochip kit, and method of producing the same and method of using the same
CA2768779A1 (en) * 2009-07-20 2011-01-27 Siloam Biosciences, Inc. Microfluidic assay platforms
US8689649B2 (en) * 2009-12-04 2014-04-08 General Electric Company Methods and systems to prevent punch loss during automated sample processing
NL1038359C2 (en) * 2010-03-31 2012-06-27 Aquamarijn Res B V Device and method for separation of circulating tumor cells.

Also Published As

Publication number Publication date
EP2855020A2 (en) 2015-04-08
EP3725409A1 (en) 2020-10-21
WO2013180567A3 (en) 2014-04-10
US9638636B2 (en) 2017-05-02
US20150160135A1 (en) 2015-06-11
WO2013180567A2 (en) 2013-12-05

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