IN2014MN02004A - - Google Patents
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- Publication number
- IN2014MN02004A IN2014MN02004A IN2004MUN2014A IN2014MN02004A IN 2014MN02004 A IN2014MN02004 A IN 2014MN02004A IN 2004MUN2014 A IN2004MUN2014 A IN 2004MUN2014A IN 2014MN02004 A IN2014MN02004 A IN 2014MN02004A
- Authority
- IN
- India
- Prior art keywords
- blood
- value
- bicarbonate
- buffer parameter
- dialysis unit
- Prior art date
Links
- 239000008280 blood Substances 0.000 abstract 12
- 210000004369 blood Anatomy 0.000 abstract 12
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 4
- 238000000502 dialysis Methods 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 1
- 239000000385 dialysis solution Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 238000011144 upstream manufacturing Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
- A61M1/1603—Regulation parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
- A61M1/1603—Regulation parameters
- A61M1/1605—Physical characteristics of the dialysate fluid
- A61M1/1609—Physical characteristics of the dialysate fluid after use, i.e. downstream of dialyser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3607—Regulation parameters
- A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
- A61M1/361—Physical characteristics of the blood, e.g. haematocrit, urea before treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3607—Regulation parameters
- A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
- A61M1/3612—Physical characteristics of the blood, e.g. haematocrit, urea after treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3672—Means preventing coagulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3672—Means preventing coagulation
- A61M1/3675—Deactivation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/30—Accessories; Auxiliary operation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/32—Controlling or regulating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/18—General characteristics of the apparatus with alarm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3324—PH measuring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
- A61M2230/202—Blood composition characteristics partial carbon oxide pressure, e.g. partial dioxide pressure (P-CO2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
- A61M2230/208—Blood composition characteristics pH-value
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04C—ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT PUMPS
- F04C2270/00—Control; Monitoring or safety arrangements
- F04C2270/04—Force
- F04C2270/042—Force radial
- F04C2270/0421—Controlled or regulated
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Water Supply & Treatment (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- External Artificial Organs (AREA)
Abstract
2Blood purification device (100 200) having an extracorporeal blood stream (102 202) with a blood inflow (103 203) to a dialysis unit (105 205) for blood removed from a patient and a blood outflow (104 204) from the dialysis unit (105 205) for blood being guided back into the patient wherein the dialysis unit (105 205) comprises an inflow (107 207) for a dialysis solution and a dialysate outflow (108 208) characterized by a control loop for closed loop control of the acid/base equilibrium of the blood wherein bicarbonate is supplied to the blood by means of an aqueous bicarbonate containing solution wherein at least one measuring means (124 124a 224 224a) for measuring a blood buffer parameter is associated with the control loop wherein the blood buffer parameter is selected from the group consisting of bicarbonate concentration and CO partial pressure and wherein a signal corresponding to the measured actual value of the blood buffer parameter can be supplied to a closed loop control apparatus (125 225) which regulates the actual value of the blood buffer parameter by the supply of the bicarbonate to a predeterminable intended value or intended value range and at least one pH measuring means (150a 250a) which is arranged upstream of the dialysis unit (105 205) in the extracorporeal blood stream (102 202) wherein a signal corresponding to the pH value can be supplied to an alarm apparatus (130 230) which triggers an alarm signal if a predeterminable pH value or pH value range is exceeded or undershot.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20120164284 EP2653178A1 (en) | 2012-04-16 | 2012-04-16 | Safety device for extracorporeal blood treatment |
| PCT/EP2013/057788 WO2013156435A1 (en) | 2012-04-16 | 2013-04-15 | Safety apparatus for extracorporeal blood treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014MN02004A true IN2014MN02004A (en) | 2015-08-07 |
Family
ID=48170449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2004MUN2014 IN2014MN02004A (en) | 2012-04-16 | 2013-04-15 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10245364B2 (en) |
| EP (2) | EP2653178A1 (en) |
| JP (1) | JP6018698B2 (en) |
| CN (1) | CN104394902B (en) |
| IN (1) | IN2014MN02004A (en) |
| WO (1) | WO2013156435A1 (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10322221B2 (en) * | 2013-01-18 | 2019-06-18 | University of Pittsburgh—of the Commonwealth System of Higher Education | Removal of carbon dioxide via dialysis |
| US10172989B2 (en) * | 2014-09-12 | 2019-01-08 | Easydial Inc. | Portable hemodialysis machine and disposable cartridge with blood leak sensor |
| DE102015012519A1 (en) | 2015-09-26 | 2017-03-30 | Fresenius Medical Care Deutschland Gmbh | Determination in blood of dissolved gases in the extracorporeal circulation |
| EP3358381A4 (en) * | 2015-09-29 | 2018-10-03 | Panasonic Intellectual Property Management Co., Ltd. | Wavelength conversion element and light emitting device |
| WO2017084683A1 (en) | 2015-11-20 | 2017-05-26 | Hepa Wash Gmbh | Method for extracorporeal lung support |
| US11351291B2 (en) | 2016-03-14 | 2022-06-07 | Advitos Gmbh | Systems or apparatuses and methods for performing dialysis |
| EP3231465B1 (en) * | 2016-04-15 | 2022-11-23 | B. Braun Avitum AG | Extracorporeal alarm suppression device |
| US20180221554A1 (en) * | 2017-02-09 | 2018-08-09 | Medtronic, Inc. | Personalized bicarbonate management systems and methods for sorbent-based hemodialysis |
| MX2019013861A (en) * | 2017-05-22 | 2020-12-07 | Advitos Gmbh | Methods and systems for removing carbon dioxide. |
| JP2020535859A (en) * | 2017-09-17 | 2020-12-10 | ケラー,スティーブン,ポール | Systems, devices, and methods for extracorporeal removal of carbon dioxide |
| US12433976B2 (en) * | 2019-01-08 | 2025-10-07 | Mozarc Medical Us Llc | Bicarbonate sensor for dialysis |
| DE102019125355A1 (en) * | 2019-09-20 | 2021-03-25 | B.Braun Avitum Ag | Method and device for controlling anticoagulation in extracorporeal blood treatment |
| ES3026213T3 (en) * | 2019-12-23 | 2025-06-10 | Gambro Lundia Ab | Apparatus for extracorporeal blood treatment |
| WO2024040052A1 (en) | 2022-08-19 | 2024-02-22 | Siemens Healthcare Diagnostics Inc. | Method of detecting an obstruction in a fluid analyzer |
| EP4587828A4 (en) * | 2022-09-12 | 2025-12-31 | Siemens Healthcare Diagnostics Inc | METHOD FOR DETECTING BLOOD CLOTS/DEPOSITES ON BLOOD GAS ANALYSIS SENSORS |
| CN117138147A (en) * | 2023-09-15 | 2023-12-01 | 广州康盛生物科技股份有限公司 | Immunoadsorption system and control method thereof |
| EP4537864A1 (en) * | 2023-10-13 | 2025-04-16 | Gambro Lundia AB | Extracorporeal blood treatment apparatus |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4451454A (en) * | 1981-06-16 | 1984-05-29 | Wong Dennis W | Prophylaxis and treatment of thromboembolic disorders in man and in warm-blooded animals with bicarbonate salts of alkali metals |
| DE3377897D1 (en) | 1982-06-21 | 1988-10-13 | Fresenius Ag | Dialysis device with controlled composition of dialysis solution |
| US4668400A (en) * | 1984-06-22 | 1987-05-26 | Veech Richard L | Hemodialysis processes and hemodialysis solutions |
| DE3640089A1 (en) * | 1986-11-24 | 1988-06-01 | Fresenius Ag | METHOD AND DEVICE FOR DETERMINING THE INTRAVASAL BLOOD VOLUME DURING HAEMODIALYSIS |
| SE465404B (en) * | 1988-03-03 | 1991-09-09 | Gambro Ab | DIALYSIS SYSTEM |
| US5032615A (en) | 1989-10-31 | 1991-07-16 | The Regents Of The University Of California | Continuous hemodialysis using citrate |
| FR2680976B1 (en) * | 1991-09-10 | 1998-12-31 | Hospal Ind | ARTIFICIAL KIDNEY PROVIDED WITH BLOOD CHARACTERISTIC MEANS OF DETERMINATION AND CORRESPONDING DETERMINATION METHOD. |
| US6156007A (en) * | 1992-09-04 | 2000-12-05 | Hemotherm, Inc. | Apparatus for whole-body hyperthermia |
| US5554272A (en) | 1995-08-10 | 1996-09-10 | Ciba Corning Diagnostics Corp. | Planar bicarbonate sensor |
| JPH1015057A (en) * | 1996-07-04 | 1998-01-20 | Inagaki Hitoshi | Dialysate characteristic change detection device and drainage liquid characteristic change detection device |
| IT1308861B1 (en) * | 1999-11-02 | 2002-01-11 | Gambro Dasco Spa | METHOD OF CONTROL OF A DIALYSIS EQUIPMENT DEDICATED TO THE IMPLEMENTATION OF THE AFBK DIALYTIC TECHNIQUE AND RELATED |
| JP2001178817A (en) * | 1999-12-24 | 2001-07-03 | Terumo Corp | Device for artificial kidney, quality evaluating device using the same and fluid circuit |
| DE60127657T8 (en) * | 2000-01-11 | 2008-04-17 | Nephros, Inc. | Blood purification system |
| CA2365517A1 (en) * | 2000-12-20 | 2002-06-20 | Dialysis Solutions Inc. | Sterile bicarbonate-free dialysis concentrate solutions |
| DE10114283C2 (en) | 2000-12-22 | 2003-04-24 | Fresenius Medical Care De Gmbh | Method for determining the ion concentration of the blood of a patient in citrate-anticoagulated hemodialysis and / or hemofiltration; dialysis machine |
| US7351218B2 (en) | 2002-12-20 | 2008-04-01 | Gambro Lundia Ab | Device and process for extracorporeal treatment by citrate anticoagulant |
| BRPI0614083A2 (en) * | 2005-08-05 | 2011-03-09 | Nat Quality Care Inc | dual channel pulsating pump and fully portable artificial kidney device (rap) |
| US8372025B2 (en) * | 2005-09-22 | 2013-02-12 | Baxter International Inc. | Automation and optimization of CRRT treatment using regional citrate anticoagulation |
| US8133194B2 (en) * | 2006-02-22 | 2012-03-13 | Henry Ford Health System | System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits |
| JP4638939B2 (en) | 2006-03-31 | 2011-02-23 | 富士通株式会社 | Threshold correction circuit, circuit and circuit board with threshold correction function |
| US8562528B2 (en) * | 2006-10-04 | 2013-10-22 | Dexcom, Inc. | Analyte sensor |
| CN101164628A (en) * | 2007-06-05 | 2008-04-23 | 佛山市第一人民医院 | Device for purifying blood and application thereof |
| AT505690B1 (en) * | 2007-08-31 | 2012-09-15 | Zentrum Fuer Biomedizinische Technologie Der Donau Uni Krems | METHOD OF DETERMINING ION CONCENTRATION IN CITRATE ANTICOAGULATED EXTRACORPORAL BLOOD CLEANING |
| JP5719345B2 (en) * | 2009-03-31 | 2015-05-20 | フレゼニウス メディカル ケアー ドイチュラント ゲゼルシャフト ミット ベシュレンクテル ハフツングFresenius Medical Care Deutschland GmbH | Apparatus and method for quantifying and controlling the concentration of at least one solute in a fluid circuit |
| DE102009018649A1 (en) * | 2009-04-23 | 2010-10-28 | Fresenius Medical Care Deutschland Gmbh | Dialysis machine, method and apparatus for a dialysis machine |
| WO2012038384A1 (en) * | 2010-09-20 | 2012-03-29 | Gambro Lundia Ab | Obtaining control settings for a dialysis machine |
| US9750862B2 (en) * | 2011-04-29 | 2017-09-05 | Medtronic, Inc. | Adaptive system for blood fluid removal |
-
2012
- 2012-04-16 EP EP20120164284 patent/EP2653178A1/en not_active Withdrawn
-
2013
- 2013-04-15 US US14/394,949 patent/US10245364B2/en active Active
- 2013-04-15 WO PCT/EP2013/057788 patent/WO2013156435A1/en not_active Ceased
- 2013-04-15 CN CN201380031623.9A patent/CN104394902B/en active Active
- 2013-04-15 JP JP2015504978A patent/JP6018698B2/en active Active
- 2013-04-15 EP EP13718152.5A patent/EP2838579B1/en active Active
- 2013-04-15 IN IN2004MUN2014 patent/IN2014MN02004A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US10245364B2 (en) | 2019-04-02 |
| US20150122712A1 (en) | 2015-05-07 |
| WO2013156435A1 (en) | 2013-10-24 |
| JP6018698B2 (en) | 2016-11-02 |
| CN104394902A (en) | 2015-03-04 |
| EP2838579A1 (en) | 2015-02-25 |
| EP2653178A1 (en) | 2013-10-23 |
| JP2015512731A (en) | 2015-04-30 |
| CN104394902B (en) | 2016-11-09 |
| EP2838579B1 (en) | 2016-03-02 |
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