IN2014MN01805A - - Google Patents

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Publication number
IN2014MN01805A
IN2014MN01805A IN1805MUN2014A IN2014MN01805A IN 2014MN01805 A IN2014MN01805 A IN 2014MN01805A IN 1805MUN2014 A IN1805MUN2014 A IN 1805MUN2014A IN 2014MN01805 A IN2014MN01805 A IN 2014MN01805A
Authority
IN
India
Prior art keywords
bioadhesive
disclosed
matrix
bioactive agent
formulation
Prior art date
Application number
Inventor
Meital Zilberman
PELEG Adaya SHEFY
Binyamin Cohen
Maytal Foox
Original Assignee
Technology Innovation Momentum Fund Israel Ltd Partnership
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technology Innovation Momentum Fund Israel Ltd Partnership filed Critical Technology Innovation Momentum Fund Israel Ltd Partnership
Publication of IN2014MN01805A publication Critical patent/IN2014MN01805A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/104—Gelatin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/04—Alginic acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Dermatology (AREA)

Abstract

A bioadhesive formulation comprising gelatin alginate and a coupling agent capable of forming a bioadhesive matrix which is characterized by rapid curing optimal viscosity high bonding strength flexibility biocompatibility and biodegradability is disclosed. Further disclosed is such a bioadhesive formulation which further comprises a bioactive agent and a drug eluting bioadhesive matrix formed therefrom the bioadhesive matrix being capable of delivering the bioactive agent to a bodily site. Methods utilizing the bioadhesive formulations and matrices in various biological and medical procedures are also disclosed.
IN1805MUN2014 2012-02-16 2013-02-14 IN2014MN01805A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261599486P 2012-02-16 2012-02-16
PCT/IL2013/050139 WO2013121429A1 (en) 2012-02-16 2013-02-14 Formulations and kits for forming bioadhesive matrices

Publications (1)

Publication Number Publication Date
IN2014MN01805A true IN2014MN01805A (en) 2015-07-03

Family

ID=48983623

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1805MUN2014 IN2014MN01805A (en) 2012-02-16 2013-02-14

Country Status (7)

Country Link
US (3) US9877926B2 (en)
EP (1) EP2814511B1 (en)
CN (2) CN104220096B (en)
CA (1) CA2864075A1 (en)
HK (1) HK1245682A1 (en)
IN (1) IN2014MN01805A (en)
WO (1) WO2013121429A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2014MN01805A (en) 2012-02-16 2015-07-03 Technology Innovation Momentum Fund Israel Ltd Partnership
EP2974752A4 (en) * 2013-03-13 2016-10-19 Nat Inst For Materials Science ADHESIVE BONE FILLER AND ADHESIVE BONE FILLER KIT
CA2993415A1 (en) * 2015-10-28 2017-05-04 Technology Innovation Momentum Fund (Israel) Limited Partnership Composite bioadhesive sealant
CN106975097A (en) * 2017-03-02 2017-07-25 四川大学 A kind of bio-medical bonding hydrogel and preparation method thereof
WO2018197946A1 (en) * 2017-04-26 2018-11-01 Meital Zilberman Hydrogel compositions including fibers and methods of use thereof
TW201932124A (en) * 2018-01-18 2019-08-16 近鎰生技股份有限公司 Hemostatic material, preparation method thereof and pharmaceutical composition containing the same
IL257357A (en) * 2018-02-05 2018-03-29 Univ Ramot Injectable scaffolds and uses thereof
CN108478849B (en) * 2018-02-07 2021-04-16 广州迈普再生医学科技股份有限公司 Absorbable and adherable hemostatic sponge and preparation method thereof
CN108785732B (en) * 2018-06-21 2021-04-09 广州迈普再生医学科技股份有限公司 Hemostatic plugging material, preparation method thereof and hemostatic plugging product
US11998654B2 (en) 2018-07-12 2024-06-04 Bard Shannon Limited Securing implants and medical devices
CN110917389B (en) * 2018-09-20 2022-03-22 广州迈普再生医学科技股份有限公司 Tissue sealing composition, tissue plugging gel and preparation method thereof
WO2021119853A1 (en) 2019-12-20 2021-06-24 The Governing Council Of The University Of Toronto Adhesive device for biomedical applications and methods of use thereof
US12397083B1 (en) * 2020-04-28 2025-08-26 Florida Southern College Active agent-eluting hemostatic agents for prevention of surgical site infection
CN111744053A (en) * 2020-05-19 2020-10-09 湖北大学 Double network surgical adhesive and preparation method thereof
US11643574B2 (en) 2021-05-28 2023-05-09 Cohesys Inc. Adhesive devices and uses thereof
CN115814148B (en) * 2022-12-26 2024-07-16 四川大学华西医院 Rapid self-gelling hemostatic powder and preparation method and application thereof

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US5284659A (en) 1990-03-30 1994-02-08 Cherukuri Subraman R Encapsulated flavor with bioadhesive character in pressed mints and confections
US5827247A (en) * 1991-08-20 1998-10-27 Bioderm External incontinence device and vapor-absorptive adhesive compositions
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KR20010013105A (en) * 1997-05-28 2001-02-26 시미즈, 야스히꼬 Collagen gel
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IN2014MN01805A (en) 2012-02-16 2015-07-03 Technology Innovation Momentum Fund Israel Ltd Partnership

Also Published As

Publication number Publication date
US20180133164A1 (en) 2018-05-17
WO2013121429A1 (en) 2013-08-22
HK1245682A1 (en) 2018-08-31
EP2814511A1 (en) 2014-12-24
US9877926B2 (en) 2018-01-30
EP2814511A4 (en) 2015-10-07
EP2814511B1 (en) 2021-10-20
CA2864075A1 (en) 2013-08-22
CN104220096A (en) 2014-12-17
CN104220096B (en) 2017-10-20
US10265274B2 (en) 2019-04-23
CN107617123A (en) 2018-01-23
US20190262276A1 (en) 2019-08-29
US20150038424A1 (en) 2015-02-05

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