IN2014MN01714A - - Google Patents
Info
- Publication number
- IN2014MN01714A IN2014MN01714A IN1714MUN2014A IN2014MN01714A IN 2014MN01714 A IN2014MN01714 A IN 2014MN01714A IN 1714MUN2014 A IN1714MUN2014 A IN 1714MUN2014A IN 2014MN01714 A IN2014MN01714 A IN 2014MN01714A
- Authority
- IN
- India
- Prior art keywords
- methods
- dried formulations
- drying
- polyol
- dried
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/125—Picornaviridae, e.g. calicivirus
- A61K39/13—Poliovirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
- C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The present invention relates to methods for producing dried formulations of biopharmaceutical agents that aim to minimize the loss of activity of the agents upon drying and to provide dried formulations with an extended shelf life. The method comprises the step of drying an aqueous solution comprising in addition to the biopharmaceutical agent at least an amino acid a polyol and a metal salt. Preferably the amino acid is glutamate the polyol is sorbitol and optionally also mannitol and the metal salt is a magnesium salt. The solution is dried by vacuum drying or by lyophilization. The methods are particularly useful for preparing dried formulations of viruses such as poliovirus or respiratory syncytial virus to be used for vaccination. The invention also relates to dried formulations prepared in accordance with the methods of the invention and to their use as medicaments e.g. as vaccines.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261606577P | 2012-03-05 | 2012-03-05 | |
EP12158086 | 2012-03-05 | ||
PCT/NL2013/050139 WO2013133702A1 (en) | 2012-03-05 | 2013-03-05 | Methods and compositions for stabilizing dried biological materials |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014MN01714A true IN2014MN01714A (en) | 2015-05-29 |
Family
ID=49117091
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN1714MUN2014 IN2014MN01714A (en) | 2012-03-05 | 2013-03-05 |
Country Status (11)
Country | Link |
---|---|
US (2) | US9827303B2 (en) |
EP (1) | EP2822540B1 (en) |
JP (1) | JP6253161B2 (en) |
KR (1) | KR102108876B1 (en) |
CN (1) | CN104271119B (en) |
AU (1) | AU2013228096B2 (en) |
BR (1) | BR112014020930A2 (en) |
CA (1) | CA2865551C (en) |
IN (1) | IN2014MN01714A (en) |
WO (1) | WO2013133702A1 (en) |
ZA (1) | ZA201407198B (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104274827B (en) * | 2013-07-01 | 2020-07-14 | 上海贺普药业股份有限公司 | Formulations of He Pula peptide |
US10538785B2 (en) | 2013-12-23 | 2020-01-21 | Renaud Vaillant | Lyophilized lentiviral vector particles, compositions and methods |
AU2017286375B2 (en) * | 2016-06-16 | 2019-04-18 | Janssen Vaccines & Prevention B.V. | HIV vaccine formulation |
JP6799135B2 (en) * | 2017-02-24 | 2020-12-09 | 久光製薬株式会社 | Manufacturing method of microneedle device |
EP3615006A4 (en) * | 2017-04-28 | 2020-12-30 | Universal Stabilization Technologies, Inc. | Antigenic thermostable polio vaccines&related methods |
JP7198264B2 (en) * | 2017-07-11 | 2022-12-28 | ユニバーサル スタビリゼイション テクノロジーズ,インコーポレイテッド | Methods for storing biopharmaceuticals |
CN111166891B (en) * | 2018-11-13 | 2022-04-05 | 中国药科大学 | Mannitol eutectic auxiliary material and preparation method and application thereof |
CN112111609A (en) * | 2020-10-29 | 2020-12-22 | 上海伯杰医疗科技有限公司 | Universal nucleic acid detection kit for enteroviruses |
CN114748615A (en) * | 2022-04-29 | 2022-07-15 | 成都安永鼎业生物技术有限公司 | Freeze-dried preparation of recombinant BCG vaccine for treatment and preparation method and application thereof |
CN115089864B (en) * | 2022-07-14 | 2023-12-29 | 复旦大学 | Method for preparing soluble microneedle patch by using freeze drying technology |
CN116763914B (en) * | 2023-02-06 | 2024-02-23 | 广东永顺生物制药股份有限公司 | Swine fever and highly pathogenic porcine reproductive and respiratory syndrome bivalent heat-resistant protective agent live vaccine and preparation method thereof |
CN117482072A (en) * | 2023-11-17 | 2024-02-02 | 上海市浦东新区公利医院(第二军医大学附属公利医院) | Application of sorbitol in preparation of medicine for treating diseases caused by respiratory syncytial virus |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2505657A1 (en) * | 1981-05-13 | 1982-11-19 | Pasteur Institut | IMPROVEMENTS IN LIVE STABILIZING AGENTS FOR THE PREPARATION OF VACCINES, AND STABILIZED VACCINES CONTAINING SAID STABILIZING AGENTS |
JPH0761955B2 (en) * | 1988-04-28 | 1995-07-05 | 国立予防衛生研究所長 | Lyophilized hepatitis A vaccine |
AU739916B2 (en) * | 1996-09-26 | 2001-10-25 | Merck Sharp & Dohme Corp. | Rotavirus vaccine formulations |
US6210683B1 (en) * | 1997-09-05 | 2001-04-03 | Merck & Co., Inc. | Stabilizers containing recombinant human serum albumin for live virus vaccines |
CA2399321C (en) * | 2000-03-07 | 2013-04-30 | Robert K. Evans | Adenovirus formulations |
AU2001275371B9 (en) * | 2000-06-08 | 2007-06-07 | Powderject Vaccines, Inc. | Powder compositions |
GB0020089D0 (en) | 2000-08-15 | 2000-10-04 | Smithkline Beecham Biolog | Vaccine Composition |
FR2814957B1 (en) * | 2000-10-06 | 2002-12-20 | Aventis Pasteur | VACCINE COMPOSITION AND STABILIZATION METHOD |
AU2004299057B2 (en) * | 2003-12-17 | 2010-06-24 | Wyeth Llc | Methods for porducing storage stable viruses and immunogenic compositions thereof |
WO2005061698A1 (en) | 2003-12-24 | 2005-07-07 | De Staat Der Nederlanden, Vertegenwoordigd Door De Minister Van Volksgezondheid, Welzijn En Sport | A respiratory syncytial virus with a genomic deficiency complemented in trans |
GB0503337D0 (en) * | 2005-02-17 | 2005-03-23 | Glaxosmithkline Biolog Sa | Compositions |
TWI398272B (en) * | 2005-03-08 | 2013-06-11 | Intervet Int Bv | Chemically defined stabiliser |
EP1909831A4 (en) * | 2005-06-14 | 2013-02-20 | Amgen Inc | Self-buffering protein formulations |
EP2509634B1 (en) * | 2009-12-11 | 2019-03-06 | Pfizer Inc | Stable formulations for lyophilizing therapeutic particles |
-
2013
- 2013-03-05 JP JP2014560879A patent/JP6253161B2/en not_active Expired - Fee Related
- 2013-03-05 IN IN1714MUN2014 patent/IN2014MN01714A/en unknown
- 2013-03-05 US US14/382,258 patent/US9827303B2/en active Active
- 2013-03-05 CN CN201380023800.9A patent/CN104271119B/en not_active Expired - Fee Related
- 2013-03-05 WO PCT/NL2013/050139 patent/WO2013133702A1/en active Application Filing
- 2013-03-05 BR BR112014020930A patent/BR112014020930A2/en active Search and Examination
- 2013-03-05 AU AU2013228096A patent/AU2013228096B2/en not_active Ceased
- 2013-03-05 KR KR1020147024688A patent/KR102108876B1/en active IP Right Grant
- 2013-03-05 EP EP13709589.9A patent/EP2822540B1/en active Active
- 2013-03-05 CA CA2865551A patent/CA2865551C/en active Active
-
2014
- 2014-10-03 ZA ZA2014/07198A patent/ZA201407198B/en unknown
-
2017
- 2017-10-27 US US15/795,545 patent/US10335479B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2013228096B2 (en) | 2017-07-13 |
US9827303B2 (en) | 2017-11-28 |
KR20150008848A (en) | 2015-01-23 |
WO2013133702A1 (en) | 2013-09-12 |
US10335479B2 (en) | 2019-07-02 |
CN104271119A (en) | 2015-01-07 |
US20150030629A1 (en) | 2015-01-29 |
CA2865551C (en) | 2021-01-12 |
KR102108876B1 (en) | 2020-05-12 |
BR112014020930A2 (en) | 2017-06-27 |
JP6253161B2 (en) | 2017-12-27 |
EP2822540A1 (en) | 2015-01-14 |
US20180055924A1 (en) | 2018-03-01 |
ZA201407198B (en) | 2016-02-24 |
CN104271119B (en) | 2018-07-10 |
JP2015509529A (en) | 2015-03-30 |
EP2822540B1 (en) | 2020-04-08 |
AU2013228096A1 (en) | 2014-09-11 |
CA2865551A1 (en) | 2013-09-12 |
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