IN2014MN01483A - - Google Patents

Info

Publication number
IN2014MN01483A
IN2014MN01483A IN1483MUN2014A IN2014MN01483A IN 2014MN01483 A IN2014MN01483 A IN 2014MN01483A IN 1483MUN2014 A IN1483MUN2014 A IN 1483MUN2014A IN 2014MN01483 A IN2014MN01483 A IN 2014MN01483A
Authority
IN
India
Prior art keywords
virulence
mixture
bendazole
papaverine
dipyridamole
Prior art date
Application number
Inventor
Artur Viktorovich Martynov
Boris Slavinovich Farber
Sofya Borisovna FARBER
Original Assignee
Artur Viktorovich Martynov
Boris Slavinovich Farber
Sofya Borisovna FARBER
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Artur Viktorovich Martynov, Boris Slavinovich Farber, Sofya Borisovna FARBER filed Critical Artur Viktorovich Martynov
Publication of IN2014MN01483A publication Critical patent/IN2014MN01483A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/36—Adaptation or attenuation of cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound

Abstract

The invention relates to biotechnology and medicine. The method for accelerating biomass growth and attenuating the virulence of bacteria involves using intracellular protein phosphorylation inducers including the cyclic adenosine monophosphate accumulation activators papaverine bendazole and dipyridamole in the form of salts or bases as inhibitors of the virulence of microorganisms. A mixture of intracellular protein phosphorylation inducers is used as low molecular weight accelerators of microorganism growth. Papaverine bendazole and dipyridamole in the form of salts or bases in specific concentrations are used as a cyclic adenosine monophosphate accumulation activator mixture. In order to attenuate the virulence of bacteria the mixture is administered to a contagious patient parenterally perorally rectally or by application to the affected region 1 10 days prior to administration of an antibiotic or in parallel therewith.
IN1483MUN2014 2011-12-28 2011-12-28 IN2014MN01483A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/RU2011/001060 WO2013100792A1 (en) 2011-12-28 2011-12-28 Method for accelerating bacterial biomass growth and attenuating the virulence of bacteria

Publications (1)

Publication Number Publication Date
IN2014MN01483A true IN2014MN01483A (en) 2015-04-17

Family

ID=48698084

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1483MUN2014 IN2014MN01483A (en) 2011-12-28 2011-12-28

Country Status (3)

Country Link
EA (1) EA025623B1 (en)
IN (1) IN2014MN01483A (en)
WO (1) WO2013100792A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA202090763A1 (en) 2017-11-15 2020-08-03 Борис Славинович ФАРБЕР PHARMACEUTICAL COMPOSITION FOR STIMULATION OF STEM CELL DIVISION AND SUPPRESSION OF BACTERIA VIRULENCE

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006133708A1 (en) * 2005-06-15 2006-12-21 Medimush A/S Bioactive agents produced by submerged cultivation of a basidiomycete cell
US20110262988A1 (en) * 2008-11-17 2011-10-27 Designer Energy Ltd. Methods and compositions for enhanced bacterial hydrolysis of cellulosic feedstocks

Also Published As

Publication number Publication date
WO2013100792A1 (en) 2013-07-04
EA025623B1 (en) 2017-01-30
EA201300205A1 (en) 2014-11-28

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