IN2014MN00880A - - Google Patents

Info

Publication number
IN2014MN00880A
IN2014MN00880A IN880MUN2014A IN2014MN00880A IN 2014MN00880 A IN2014MN00880 A IN 2014MN00880A IN 880MUN2014 A IN880MUN2014 A IN 880MUN2014A IN 2014MN00880 A IN2014MN00880 A IN 2014MN00880A
Authority
IN
India
Prior art keywords
composition
degrees celsius
buffer
viscosity
mpas
Prior art date
Application number
Inventor
Evan C Unger
Jennifer L Johnson
Original Assignee
Nuvox Pharma L L C
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuvox Pharma L L C filed Critical Nuvox Pharma L L C
Publication of IN2014MN00880A publication Critical patent/IN2014MN00880A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Abstract

An oxygen therapeutic composition comprising a perfluorocarbon material a viscosity modifier a buffer wherein the buffer stabilizes a pH of the composition at between about 6.5 to about 7.5 and wherein the composition comprises a viscosity of about 2.0 to about 3.5 mPas and wherein the fluorocarbon has a boiling point of about 4 degrees Celsius to about 60 degrees Celsius.
IN880MUN2014 2011-10-13 2012-10-15 IN2014MN00880A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/273,115 US8822549B2 (en) 2011-10-13 2011-10-13 Buffered oxygen therapeutic
PCT/US2012/060284 WO2013056246A1 (en) 2011-10-13 2012-10-15 Buffered oxygen therapeutic

Publications (1)

Publication Number Publication Date
IN2014MN00880A true IN2014MN00880A (en) 2015-04-17

Family

ID=48082584

Family Applications (1)

Application Number Title Priority Date Filing Date
IN880MUN2014 IN2014MN00880A (en) 2011-10-13 2012-10-15

Country Status (8)

Country Link
US (1) US8822549B2 (en)
EP (1) EP2766001A4 (en)
JP (3) JP6117220B2 (en)
CN (2) CN108685882A (en)
AU (1) AU2012323862B2 (en)
CA (2) CA2851522C (en)
IN (1) IN2014MN00880A (en)
WO (1) WO2013056246A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9700523B2 (en) * 2011-10-13 2017-07-11 Nuvox Pharma Llc Buffered oxygen therapeutic
US8822549B2 (en) * 2011-10-13 2014-09-02 Jennifer L. Johnson Buffered oxygen therapeutic
US20160206570A1 (en) * 2013-09-03 2016-07-21 Ariziba Board Of Regents On Behalf Of The University If Arizona Cardioprotectant to reduce damage from heart attack
CN106488766A (en) * 2014-03-05 2017-03-08 埃文·C·昂格尔 Fractionation radiotherapy and chemotherapy using oxygen therapy
IL298236B1 (en) * 2015-12-21 2024-01-01 Nuvox Pharma Llc Compositions of fluorocarbon nanoemulsion, and methods of preparation and use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4423077A (en) * 1982-07-27 1983-12-27 The University Of Pennsylvania Perfluorochemical emulsion artificial blood
US5656211A (en) * 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5114932A (en) * 1990-11-30 1992-05-19 Runge Thomas M Hyperosmolar oxyreplete hemosubstitute
US5196199A (en) * 1990-12-14 1993-03-23 Fuisz Technologies Ltd. Hydrophilic form of perfluoro compounds and method of manufacture
US5628930A (en) 1992-10-27 1997-05-13 Alliance Pharmaceutical Corp. Stabilization of fluorocarbon emulsions
US5595687A (en) 1992-10-30 1997-01-21 Thomas Jefferson University Emulsion stability
NZ262237A (en) 1993-01-25 1997-06-24 Sonus Pharma Inc Ultrasound contrast agents comprising phase shift colloids having a boiling point below the body temperature of the animal it is used in
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
US20030032879A1 (en) 1997-07-07 2003-02-13 Steven Quay Microbubble formation using ultrasound
US7357937B2 (en) * 2002-09-24 2008-04-15 Therox, Inc. Perfluorocarbon emulsions with non-fluorinated surfactants
CA2756685C (en) 2009-04-15 2019-12-24 Oxygen Biotherapeutics, Inc. Emulsions of perfluorocarbons
US8822549B2 (en) * 2011-10-13 2014-09-02 Jennifer L. Johnson Buffered oxygen therapeutic

Also Published As

Publication number Publication date
EP2766001A4 (en) 2015-06-10
JP6479870B2 (en) 2019-03-06
JP6789328B2 (en) 2020-11-25
CA2851522A1 (en) 2013-04-18
AU2012323862B2 (en) 2015-07-09
JP2019089816A (en) 2019-06-13
CN108685882A (en) 2018-10-23
CN104039317A (en) 2014-09-10
CA3057480C (en) 2021-07-20
WO2013056246A1 (en) 2013-04-18
JP6117220B2 (en) 2017-04-19
AU2012323862A1 (en) 2014-05-29
JP2014528487A (en) 2014-10-27
CA3057480A1 (en) 2013-04-18
CA2851522C (en) 2019-11-26
EP2766001A1 (en) 2014-08-20
US20130096204A1 (en) 2013-04-18
JP2017132789A (en) 2017-08-03
CN104039317B (en) 2018-05-25
US8822549B2 (en) 2014-09-02

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