IN2014KN01319A - - Google Patents

Info

Publication number
IN2014KN01319A
IN2014KN01319A IN1319KON2014A IN2014KN01319A IN 2014KN01319 A IN2014KN01319 A IN 2014KN01319A IN 1319KON2014 A IN1319KON2014 A IN 1319KON2014A IN 2014KN01319 A IN2014KN01319 A IN 2014KN01319A
Authority
IN
India
Prior art keywords
formula
cinacalcet
pharmaceutically acceptable
acceptable salts
ethylamine
Prior art date
Application number
Inventor
Ruzena Vlasakova
Josef Hajicek
Original Assignee
Zentiva Ks
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva Ks filed Critical Zentiva Ks
Publication of IN2014KN01319A publication Critical patent/IN2014KN01319A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/14—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups
    • C07C209/16—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings

Abstract

A new efficient method of producing Cinacalcet of formula I and its pharmaceutically acceptable salts which consists in direct alkylation of (R) (1 naphthyl)ethylamine of formula III with 3 [3 (trifluoromethyl)phenyl]propanol of formula II in presence of a catalyst in an inert organic solvent. Use of Cinacalcet of formula I prepared by the claimed method in preparation of pharmaceutically acceptable salts of Cinacalcet.
IN1319KON2014 2011-11-25 2012-11-21 IN2014KN01319A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20110770A CZ2011770A3 (en) 2011-11-25 2011-11-25 Process for preparing cinacalcet
PCT/CZ2012/000119 WO2013075679A1 (en) 2011-11-25 2012-11-21 A method of producing cinacalcet

Publications (1)

Publication Number Publication Date
IN2014KN01319A true IN2014KN01319A (en) 2015-10-16

Family

ID=47435672

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1319KON2014 IN2014KN01319A (en) 2011-11-25 2012-11-21

Country Status (7)

Country Link
CN (1) CN103958456B (en)
BR (1) BR112014012434A2 (en)
CZ (1) CZ2011770A3 (en)
HU (1) HUP1400341A3 (en)
IL (1) IL232678A (en)
IN (1) IN2014KN01319A (en)
WO (1) WO2013075679A1 (en)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011068A (en) 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5504253A (en) 1994-07-15 1996-04-02 Nps Pharmaceuticals, Inc. Amine preparation
EP1275635A1 (en) 1994-10-21 2003-01-15 Nps Pharmaceuticals, Inc. Calcium receptor-active compounds
ES2332016T3 (en) * 2005-05-16 2010-01-22 Teva Pharmaceutical Industries Ltd. PROCEDURE FOR THE PREPARATION OF CINACALCET HYDROCLORIDE.
MX2007000983A (en) * 2005-05-23 2007-04-16 Teva Pharma Processes for preparing cinacalcet hydrochloride crystal form i.
US7393967B2 (en) 2006-04-27 2008-07-01 Teva Pharmaceutical Industries Ltd. Process for the preparation of cinacalcet base
WO2007127445A2 (en) 2006-04-27 2007-11-08 Teva Pharmaceutical Industries Ltd. Process for the preparation of cinacalcet base
US20100267988A1 (en) 2006-06-08 2010-10-21 Medichem, S.A. Processes for preparing intermediate compounds useful for the preparation of cinacalcet
ES2569483T3 (en) * 2007-06-21 2016-05-11 Amgen Inc. Methods to synthesize cinacalcet and salts thereof
WO2010049293A2 (en) * 2008-10-28 2010-05-06 Zach System S.P.A. Process for preparing cinacalcet

Also Published As

Publication number Publication date
CN103958456B (en) 2015-10-21
HUP1400341A3 (en) 2014-12-29
CN103958456A (en) 2014-07-30
BR112014012434A2 (en) 2017-06-06
CZ303627B6 (en) 2013-01-16
HUP1400341A2 (en) 2014-10-28
CZ2011770A3 (en) 2013-01-16
IL232678A (en) 2017-05-29
WO2013075679A1 (en) 2013-05-30
IL232678A0 (en) 2014-08-03

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