IN2014KN01208A - - Google Patents

Info

Publication number
IN2014KN01208A
IN2014KN01208A IN1208KON2014A IN2014KN01208A IN 2014KN01208 A IN2014KN01208 A IN 2014KN01208A IN 1208KON2014 A IN1208KON2014 A IN 1208KON2014A IN 2014KN01208 A IN2014KN01208 A IN 2014KN01208A
Authority
IN
India
Prior art keywords
teicoplanin
decoloured
colours
eluted
cation
Prior art date
Application number
Inventor
Samo Andrensek
Rok Grahek
Tomaz Marko
Original Assignee
Lek Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Pharmaceuticals filed Critical Lek Pharmaceuticals
Publication of IN2014KN01208A publication Critical patent/IN2014KN01208A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention provides an inexpensive process for isolation of teicoplanin from a fermentation culture of Actinoplanes teichomyceticus in a grade for pharmaceutical application with substantial removal of colours. Applying optimal combination of cation and anion exchange techniques together with further improved purification affords a unique decoloured teicoplanin material. According to some embodiments the glycopeptide antibiotic is eluted from the ion exchange column at a pH from 5 to below 9.
IN1208KON2014 2011-11-11 2012-11-09 IN2014KN01208A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11188776.6A EP2592090A1 (en) 2011-11-11 2011-11-11 Process of purification of teicoplanin
PCT/EP2012/072226 WO2013068517A1 (en) 2011-11-11 2012-11-09 Process of purification of teicoplanin

Publications (1)

Publication Number Publication Date
IN2014KN01208A true IN2014KN01208A (en) 2015-10-16

Family

ID=47172623

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1208KON2014 IN2014KN01208A (en) 2011-11-11 2012-11-09

Country Status (10)

Country Link
EP (2) EP2592090A1 (en)
KR (1) KR102040344B1 (en)
CN (1) CN104080798A (en)
DK (1) DK2776453T3 (en)
ES (1) ES2558603T3 (en)
HU (1) HUE026336T2 (en)
IN (1) IN2014KN01208A (en)
PL (1) PL2776453T3 (en)
SI (1) SI2776453T1 (en)
WO (1) WO2013068517A1 (en)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1496386A (en) 1975-03-05 1977-12-30 Lepetit Spa Antibiotics
GB8608798D0 (en) 1986-04-11 1986-05-14 Lepetit Spa Recovery of glycopeptide antibiotics from aqueous solutions
US4845194A (en) 1987-02-27 1989-07-04 Eli Lilly And Company Glycopeptide recovery process
DK0479086T3 (en) 1990-10-01 1995-10-23 Lepetit Spa Process for the recovery of teicoplanin
KR100321304B1 (en) 1999-04-16 2002-03-18 박호군 Process for Purifying Teicoplanin
KR100367890B1 (en) 2000-03-02 2003-01-14 은언기 Lappimg/Polishing Wheel and the manufacturing method thereof
KR20030017067A (en) 2001-08-23 2003-03-03 정용진 Mutation Strain Actinoplanes Teichomyceticus var jianesis And The Method For Producing Teicoplanin Therefrom
KR100459289B1 (en) 2002-05-30 2004-12-03 이연제약주식회사 Method for recovering teicoplanin a2 from fermentation broth
KR100476818B1 (en) * 2002-07-19 2005-03-17 종근당바이오 주식회사 Purification method for teicoplanin A2
KR100652320B1 (en) * 2004-02-16 2006-11-29 근화제약주식회사 Method for the isolation and purification of teicoplanin
KR100474653B1 (en) * 2004-04-16 2005-03-14 동국제약 주식회사 Preparation Method of Teicoplanin with High Productivity and Purity
KR100554481B1 (en) * 2004-06-30 2006-03-03 씨제이 주식회사 Process for the purification of vancomycin HCl
CA2577854C (en) * 2004-10-27 2013-12-03 Alpharma Aps Purification of glycopeptides
EP1798237A1 (en) * 2005-12-16 2007-06-20 Pharmatex Italia Srl Process for the purification of macrolide antibiotics

Also Published As

Publication number Publication date
ES2558603T3 (en) 2016-02-05
EP2776453A1 (en) 2014-09-17
KR102040344B1 (en) 2019-11-04
DK2776453T3 (en) 2016-01-18
SI2776453T1 (en) 2016-04-29
KR20140091738A (en) 2014-07-22
WO2013068517A1 (en) 2013-05-16
PL2776453T3 (en) 2016-03-31
EP2776453B1 (en) 2015-10-07
HUE026336T2 (en) 2016-05-30
CN104080798A (en) 2014-10-01
EP2592090A1 (en) 2013-05-15

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