IN2014DN11101A - - Google Patents

Info

Publication number
IN2014DN11101A
IN2014DN11101A IN11101DEN2014A IN2014DN11101A IN 2014DN11101 A IN2014DN11101 A IN 2014DN11101A IN 11101DEN2014 A IN11101DEN2014 A IN 11101DEN2014A IN 2014DN11101 A IN2014DN11101 A IN 2014DN11101A
Authority
IN
India
Prior art keywords
pazam
acrylamide
present disclosure
covalently attached
polymer
Prior art date
Application number
Inventor
Wayne N George
Daniel Bratton
Andrew A Brown
Hongji Ren
Ryan C Smith
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc filed Critical Illumina Inc
Publication of IN2014DN11101A publication Critical patent/IN2014DN11101A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09DCOATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D133/00Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
    • C09D133/24Homopolymers or copolymers of amides or imides
    • C09D133/26Homopolymers or copolymers of acrylamide or methacrylamide
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05DPROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D3/00Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
    • B05D3/06Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to radiation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05DPROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D3/00Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
    • B05D3/06Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to radiation
    • B05D3/061Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to radiation using U.V.
    • B05D3/065After-treatment
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09DCOATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D135/00Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least another carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Coating compositions based on derivatives of such polymers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/24Structurally defined web or sheet [e.g., overall dimension, etc.]
    • Y10T428/24802Discontinuous or differential coating, impregnation or bond [e.g., artwork, printing, retouched photograph, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/24Structurally defined web or sheet [e.g., overall dimension, etc.]
    • Y10T428/24802Discontinuous or differential coating, impregnation or bond [e.g., artwork, printing, retouched photograph, etc.]
    • Y10T428/24917Discontinuous or differential coating, impregnation or bond [e.g., artwork, printing, retouched photograph, etc.] including metal layer
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/24Structurally defined web or sheet [e.g., overall dimension, etc.]
    • Y10T428/24802Discontinuous or differential coating, impregnation or bond [e.g., artwork, printing, retouched photograph, etc.]
    • Y10T428/24926Discontinuous or differential coating, impregnation or bond [e.g., artwork, printing, retouched photograph, etc.] including ceramic, glass, porcelain or quartz layer
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991Coated
    • Y10T428/2998Coated including synthetic resin or polymer
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/31504Composite [nonstructural laminate]
    • Y10T428/31536Including interfacial reaction product of adjacent layers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/31504Composite [nonstructural laminate]
    • Y10T428/31855Of addition polymer from unsaturated monomers
    • Y10T428/31935Ester, halide or nitrile of addition polymer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Materials Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Laminated Bodies (AREA)
  • Paints Or Removers (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Medicinal Preparation (AREA)
  • Surface Treatment Of Glass (AREA)

Abstract

The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings such as poly(N-(5 azidoacetamidylpentyl)acrylamide co acrylamide) (PAZAM) in the formation and manipulation of substrates such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer such as PAZAM and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.
IN11101DEN2014 2012-06-08 2013-06-05 IN2014DN11101A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261657508P 2012-06-08 2012-06-08
US201361753833P 2013-01-17 2013-01-17
US13/784,368 US9012022B2 (en) 2012-06-08 2013-03-04 Polymer coatings
PCT/US2013/044305 WO2013184796A1 (en) 2012-06-08 2013-06-05 Polymer coatings

Publications (1)

Publication Number Publication Date
IN2014DN11101A true IN2014DN11101A (en) 2015-09-25

Family

ID=48670088

Family Applications (1)

Application Number Title Priority Date Filing Date
IN11101DEN2014 IN2014DN11101A (en) 2012-06-08 2013-06-05

Country Status (15)

Country Link
US (6) US9012022B2 (en)
EP (2) EP3792320A1 (en)
JP (3) JP5859172B2 (en)
KR (1) KR101559983B1 (en)
CN (2) CN108165119B (en)
AU (1) AU2013271677B2 (en)
CA (1) CA2875671C (en)
DK (1) DK2859055T3 (en)
ES (1) ES2859823T3 (en)
HK (1) HK1208697A1 (en)
IL (1) IL236023B (en)
IN (1) IN2014DN11101A (en)
PL (1) PL2859055T3 (en)
PT (1) PT2859055T (en)
WO (1) WO2013184796A1 (en)

Families Citing this family (178)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
AU2011237729B2 (en) 2010-04-05 2014-04-03 Prognosys Biosciences, Inc. Spatially encoded biological assays
US9074251B2 (en) 2011-02-10 2015-07-07 Illumina, Inc. Linking sequence reads using paired code tags
WO2012106546A2 (en) 2011-02-02 2012-08-09 University Of Washington Through Its Center For Commercialization Massively parallel continguity mapping
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
CA2856163C (en) 2011-10-28 2019-05-07 Illumina, Inc. Microarray fabrication system and method
US9012022B2 (en) * 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
US8895249B2 (en) 2012-06-15 2014-11-25 Illumina, Inc. Kinetic exclusion amplification of nucleic acid libraries
EP3901280A1 (en) 2012-10-17 2021-10-27 Spatial Transcriptomics AB Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
US9683230B2 (en) 2013-01-09 2017-06-20 Illumina Cambridge Limited Sample preparation on a solid support
US9512422B2 (en) 2013-02-26 2016-12-06 Illumina, Inc. Gel patterned surfaces
US10557133B2 (en) 2013-03-13 2020-02-11 Illumina, Inc. Methods and compositions for nucleic acid sequencing
AU2013382089B2 (en) 2013-03-13 2018-05-10 Illumina, Inc. Multilayer fluidic devices and methods for their fabrication
US9193998B2 (en) 2013-03-15 2015-11-24 Illumina, Inc. Super resolution imaging
US20140274747A1 (en) 2013-03-15 2014-09-18 Illumina, Inc. Super resolution imaging
EP4234716A3 (en) 2013-06-25 2023-12-06 Prognosys Biosciences, Inc. Methods for determining spatial patterns of biological targets in a sample
KR102266002B1 (en) 2013-07-01 2021-06-16 일루미나, 인코포레이티드 Catalyst-free surface functionalization and polymer grafting
ES2628485T3 (en) 2013-07-03 2017-08-03 Illumina, Inc. Sequencing by orthogonal synthesis
EP3038834B1 (en) 2013-08-30 2018-12-12 Illumina, Inc. Manipulation of droplets on hydrophilic or variegated-hydrophilic surfaces
US10540783B2 (en) * 2013-11-01 2020-01-21 Illumina, Inc. Image analysis useful for patterned objects
CA2928598C (en) * 2013-12-19 2022-11-29 M. Shane Bowen Substrates comprising nano-patterning surfaces and methods of preparing thereof
DK3083994T3 (en) 2013-12-20 2021-09-13 Illumina Inc Preservation of genomic connectivity information in fragmented genomic DNA samples
CN106062212A (en) 2013-12-23 2016-10-26 伊鲁米那股份有限公司 Structured substrates for improving detection of light emissions and methods relating to the same
US10156572B2 (en) 2014-02-18 2018-12-18 Arizona Board Of Regents On Behalf Of Arizona State University Three arm Y-shaped bisbiotin ligand
SG10201809312QA (en) 2014-05-16 2018-11-29 Illumina Inc Nucleic acid synthesis techniques
KR102231650B1 (en) 2014-05-27 2021-03-23 일루미나, 인코포레이티드 Systems and methods for biochemical analysis including a base instrument and a removable cartridge
KR102499300B1 (en) 2014-06-05 2023-02-10 일루미나, 인코포레이티드 Systems and methods including a rotary valve for at least one of sample preparation or sample analysis
WO2016003814A1 (en) 2014-06-30 2016-01-07 Illumina, Inc. Methods and compositions using one-sided transposition
US9982250B2 (en) 2014-08-21 2018-05-29 Illumina Cambridge Limited Reversible surface functionalization
EP3191606B1 (en) 2014-09-12 2020-05-27 Illumina, Inc. Methods for detecting the presence of polymer subunits using chemiluminescence
CN106999850B (en) 2014-10-09 2020-04-07 亿明达股份有限公司 Method and apparatus for separating immiscible liquids to effectively isolate at least one liquid
IL299976B1 (en) 2014-10-17 2024-07-01 Illumina Cambridge Ltd Contiguity preserving transposition
ES2905706T3 (en) * 2014-10-31 2022-04-11 Illumina Cambridge Ltd DNA copolymer polymers and coatings
SG10202004350TA (en) 2014-11-11 2020-06-29 Illumina Cambridge Ltd Methods and arrays for producing and sequencing monoclonal clusters of nucleic acid
DK3234187T3 (en) 2014-12-15 2021-05-25 Illumina Inc Method for single molecule placement on a substrate
CA2982146A1 (en) 2015-04-10 2016-10-13 Spatial Transcriptomics Ab Spatially distinguished, multiplex nucleic acid analysis of biological specimens
EP3696536A1 (en) 2015-04-14 2020-08-19 Illumina, Inc. A method of manufacturing a substrate and a method of analyzing biomolecules capable of generating light emissions
KR102333255B1 (en) 2015-05-11 2021-12-01 일루미나, 인코포레이티드 Platform for discovery and analysis of therapeutic agents
KR102054571B1 (en) 2015-05-29 2019-12-10 일루미나 케임브리지 리미티드 Improved Use of Surface Primers in Clusters
WO2017007753A1 (en) 2015-07-07 2017-01-12 Illumina, Inc. Selective surface patterning via nanoimrinting
CN107835857A (en) * 2015-07-17 2018-03-23 亿明达股份有限公司 For the polymer sheet layer of application to be sequenced
ES2864677T3 (en) 2015-07-30 2021-10-14 Illumina Inc Orthogonal nucleotide unlocking
ES2868195T3 (en) 2015-08-14 2021-10-21 Illumina Inc Systems and methods that use magnetically sensitive sensors to determine a genetic trait
CA3008031A1 (en) 2016-01-11 2017-07-20 Illumina Singapore Pte Ltd Detection apparatus having a microfluorometer, a fluidic system, and a flow cell latch clamp module
EP4053545A1 (en) 2016-03-24 2022-09-07 Illumina, Inc. Photonic superlattice-based devices and compositions for use in luminescent imaging, and methods of using the same
PT3377226T (en) 2016-03-28 2021-04-15 Illumina Inc Multi-plane microarrays
IL262447B2 (en) 2016-04-22 2023-09-01 Illumina Inc Photonic stucture-based devices and compositions for use in luminescent imaging of multiple sites within a pixel, and methods of using the same
JP6824290B2 (en) * 2016-05-18 2021-02-03 イルミナ インコーポレイテッド Self-assembled patterning with a patterned hydrophobic surface
US10385214B2 (en) 2016-09-30 2019-08-20 Illumina Cambridge Limited Fluorescent dyes and their uses as biomarkers
ES2937782T3 (en) 2016-10-03 2023-03-31 Illumina Inc Fluorescent detection of amines and hydrazines and methods of testing the same
CN110325651B (en) 2016-12-22 2024-03-15 伊鲁米那股份有限公司 Arrays with quality control tracers
WO2018114710A1 (en) 2016-12-22 2018-06-28 Illumina Cambridge Limited Coumarin compounds and their uses as fluorescent labels
EP3559745B1 (en) 2016-12-22 2024-02-14 Illumina, Inc. Imprinting apparatus
KR102512186B1 (en) 2016-12-22 2023-03-20 일루미나, 인코포레이티드 Array comprising a resin film and a patterned polymer layer
MY196044A (en) * 2016-12-22 2023-03-09 Illumina Inc Flow Cell Package And Method For Making The Same
KR102586847B1 (en) 2016-12-22 2023-10-10 일루미나, 인코포레이티드 Arrays containing sequencing primers and non-sequencing entities
GB201704754D0 (en) 2017-01-05 2017-05-10 Illumina Inc Kinetic exclusion amplification of nucleic acid libraries
WO2018136117A1 (en) 2017-01-20 2018-07-26 Omniome, Inc. Allele-specific capture of nucleic acids
SG11201906569XA (en) 2017-01-20 2019-08-27 Omniome Inc Genotyping by polymerase binding
GB201701691D0 (en) 2017-02-01 2017-03-15 Illumina Inc System and method with reflective fiducials
GB201701686D0 (en) 2017-02-01 2017-03-15 Illunina Inc System & method with fiducials having offset layouts
GB201701689D0 (en) 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials of non-closed shapes
GB201701688D0 (en) 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials in non-recliner layouts
EP3576868A4 (en) 2017-02-01 2021-03-17 Illumina, Inc. System and method with fiducials responding to multiple excitation frequencies
NL2019044B1 (en) * 2017-05-11 2018-11-15 Illumina Inc Protective surface coatings for flow cells
WO2019028047A1 (en) 2017-08-01 2019-02-07 Illumina, Inc Spatial indexing of genetic material and library preparation using hydrogel beads and flow cells
GB201716931D0 (en) 2017-10-16 2017-11-29 Illumina Cambridge Ltd New fluorescent compounds and their use as biomarkers
AU2018392919B2 (en) * 2017-12-21 2021-04-15 Illumina Cambridge Limited Flow cells with hydrogel coating
CA3067227C (en) * 2017-12-22 2023-07-18 Illumina, Inc. Catalytically active substances
DK3794012T3 (en) 2018-05-15 2024-01-08 Illumina Inc COMPOSITIONS AND METHODS FOR CHEMICAL CLEAVAGE AND PROTECTION OF SURFACE BOUND OLIGONUCLEOTIDES
US10495443B1 (en) 2018-07-26 2019-12-03 Qiagen Sciences, Llc Fiducial marking system
CN109111541B (en) * 2018-08-20 2020-08-04 江南大学 Preparation method of azido-containing high molecular polymer
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
WO2020047005A1 (en) 2018-08-28 2020-03-05 10X Genomics, Inc. Resolving spatial arrays
CN113767175A (en) 2018-08-28 2021-12-07 10X基因组学股份有限公司 Increasing spatial array resolution
CA3113271A1 (en) * 2018-10-26 2020-04-30 Illumina, Inc. Modulating polymer beads for dna processing
US20200149095A1 (en) * 2018-11-14 2020-05-14 Element Biosciences, Inc. Low binding supports for improved solid-phase dna hybridization and amplification
US10876148B2 (en) * 2018-11-14 2020-12-29 Element Biosciences, Inc. De novo surface preparation and uses thereof
US10704094B1 (en) 2018-11-14 2020-07-07 Element Biosciences, Inc. Multipart reagents having increased avidity for polymerase binding
KR20210098842A (en) 2018-12-05 2021-08-11 일루미나 케임브리지 리미티드 Methods and compositions for cluster generation by bridge amplification
US20220049294A1 (en) 2018-12-10 2022-02-17 10X Genomics, Inc. Imaging system hardware
KR20210104650A (en) * 2018-12-17 2021-08-25 일루미나, 인코포레이티드 Methods and means for constructing libraries for sequencing
CA3103633A1 (en) 2018-12-18 2020-06-25 Illumina Cambridge Limited Methods and compositions for paired end sequencing using a single surface primer
WO2020126598A1 (en) 2018-12-18 2020-06-25 Illumina Cambridge Limited Heterocyclic azide units and their use in polymer coatings
WO2020132103A1 (en) 2018-12-19 2020-06-25 Illumina, Inc. Methods for improving polynucleotide cluster clonality priority
US11293061B2 (en) 2018-12-26 2022-04-05 Illumina Cambridge Limited Sequencing methods using nucleotides with 3′ AOM blocking group
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
AU2019422318A1 (en) * 2019-01-14 2021-01-07 Illumina Cambridge Limited Flow cell including a heteropolymer
TW202045709A (en) 2019-01-29 2020-12-16 美商伊路米納有限公司 Flow cells
TW202043486A (en) 2019-01-29 2020-12-01 美商伊路米納有限公司 Sequencing kits
WO2020176788A1 (en) 2019-02-28 2020-09-03 10X Genomics, Inc. Profiling of biological analytes with spatially barcoded oligonucleotide arrays
WO2020178231A1 (en) 2019-03-01 2020-09-10 Illumina, Inc. Multiplexed fluorescent detection of analytes
MX2020013416A (en) 2019-03-01 2021-04-28 Illumina Cambridge Ltd Tertiary amine substituted coumarin compounds and their uses as fluorescent labels.
NL2023327B1 (en) 2019-03-01 2020-09-17 Illumina Inc Multiplexed fluorescent detection of analytes
EP3931263A1 (en) 2019-03-01 2022-01-05 Illumina Cambridge Limited Exocyclic amine substituted coumarin compounds and their uses as fluorescent labels
WO2020190509A1 (en) 2019-03-15 2020-09-24 10X Genomics, Inc. Methods for using spatial arrays for single cell sequencing
EP3887542A1 (en) 2019-03-22 2021-10-06 10X Genomics, Inc. Three-dimensional spatial analysis
US11421271B2 (en) 2019-03-28 2022-08-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing using photoswitchable labels
CN110055318A (en) * 2019-05-06 2019-07-26 南京拓远生物科技有限公司 A kind of preparation method of the three dimensional DNA microarray surface based on click chemistry
EP3976751A4 (en) 2019-05-31 2023-01-11 Illumina, Inc. Flow cell with one or more barrier features
US11590505B2 (en) 2019-05-31 2023-02-28 Illumina, Inc. System and method for storage
CN112689682A (en) 2019-05-31 2021-04-20 伊鲁米纳公司 Obtaining information from a biological sample in a flow cell
CN112673251A (en) 2019-05-31 2021-04-16 伊鲁米那股份有限公司 Flow cell for selective deposition or activation of nucleotides
CN112654719A (en) 2019-05-31 2021-04-13 伊鲁米纳公司 System and method for information storage and retrieval using flow cells
WO2020243075A1 (en) 2019-05-31 2020-12-03 Illumina, Inc. Storage device, system, and method
WO2021011803A1 (en) 2019-07-16 2021-01-21 Omniome, Inc. Synthetic nucleic acids having non-natural structures
CN113302311A (en) * 2019-08-01 2021-08-24 伊鲁米纳公司 Flow cell
WO2021067514A1 (en) 2019-10-01 2021-04-08 10X Genomics, Inc. Systems and methods for identifying morphological patterns in tissue samples
WO2021091611A1 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Spatially-tagged analyte capture agents for analyte multiplexing
EP4062316A1 (en) 2019-11-18 2022-09-28 10X Genomics, Inc. Systems and methods for tissue classification
CA3158888A1 (en) 2019-11-21 2021-05-27 Yifeng YIN Spatial analysis of analytes
EP4062372B1 (en) 2019-11-22 2024-05-08 10X Genomics, Inc. Systems and methods for spatial analysis of analytes using fiducial alignment
CN114829369A (en) 2019-11-27 2022-07-29 伊鲁米纳剑桥有限公司 Dyes and compositions containing cyclooctatetraene
CN111171228B (en) * 2020-01-20 2022-03-08 赛纳生物科技(北京)有限公司 Preparation method of linear hydrogel containing azide functional groups
WO2021148809A1 (en) 2020-01-22 2021-07-29 Nuclera Nucleics Ltd Methods of nucleic acid synthesis
CN111171229B (en) * 2020-02-12 2021-12-28 赛纳生物科技(北京)有限公司 Preparation method of nucleic acid immobilized microspheres
US11188778B1 (en) 2020-05-05 2021-11-30 Illumina, Inc. Equalization-based image processing and spatial crosstalk attenuator
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
MX2022016492A (en) 2020-06-22 2023-03-06 Illumina Cambridge Ltd Nucleosides and nucleotides with 3' acetal blocking group.
US11981964B2 (en) 2020-07-28 2024-05-14 Illumina Cambridge Limited Substituted coumarin dyes and uses as fluorescent labels
CN116171330A (en) 2020-08-06 2023-05-26 Illumina公司 RNA and DNA sequencing libraries using bead-linked transposomes
AU2021364529A1 (en) * 2020-10-20 2023-01-05 Illumina, Inc. Flow cells
US20220195196A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Alkylpyridinium coumarin dyes and uses in sequencing applications
US20220195517A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Long stokes shift chromenoquinoline dyes and uses in sequencing applications
US20220195516A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
US20220195518A1 (en) 2020-12-22 2022-06-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing
EP4274857A1 (en) 2021-01-05 2023-11-15 Illumina Inc Compositions including functional groups coupled to substrates, and methods of making the same
US20240117416A1 (en) 2021-01-29 2024-04-11 Illumina, Inc. Methods, compositions and kits to improve seeding efficiency of flow cells with polynucleotides
WO2022192083A1 (en) * 2021-03-09 2022-09-15 Illumina, Inc. Polymers, methods of making polymers, and methods of coupling oligonucleotides to polymers
AU2022245985A1 (en) 2021-03-22 2023-09-21 Illumina Cambridge Limited Methods for improving nucleic acid cluster clonality
MX2023011749A (en) * 2021-04-30 2024-01-12 Illumina Cambridge Ltd Flow cell and methods.
JP2024516191A (en) 2021-05-05 2024-04-12 イルミナ ケンブリッジ リミテッド Fluorescent dyes containing bis-boron fused heterocycles and their use in sequencing - Patents.com
CN117916390A (en) 2021-05-20 2024-04-19 伊鲁米纳公司 Compositions and methods for sequencing-by-synthesis
CN117677435A (en) 2021-06-15 2024-03-08 伊鲁米纳公司 Surface functionalization of non-aqueous gels for sequencing
EP4359129A1 (en) 2021-06-25 2024-05-01 Illumina, Inc. Linear fourier fiducial
EP4359122A1 (en) 2021-06-25 2024-05-01 Illumina, Inc. Fiducials for use in registration of a patterned surface
US11455487B1 (en) 2021-10-26 2022-09-27 Illumina Software, Inc. Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling
CN113265232B (en) * 2021-07-21 2021-09-28 山东诺尔生物科技有限公司 Raw material composition for coating agent, preparation method and application thereof
CN117813391A (en) 2021-07-23 2024-04-02 因美纳有限公司 Method for preparing substrate surface for DNA sequencing
WO2023044071A1 (en) 2021-09-17 2023-03-23 10X Genomics, Inc. Systems and methods for image registration or alignment
WO2023056328A2 (en) 2021-09-30 2023-04-06 Illumina, Inc. Solid supports and methods for depleting and/or enriching library fragments prepared from biosamples
US20230140008A1 (en) 2021-10-06 2023-05-04 10X Genomics, Inc. Systems and methods for evaluating biological samples
CA3234961A1 (en) 2021-10-20 2023-04-27 Illumina, Inc. Methods for capturing library dna for sequencing
US20230167495A1 (en) 2021-11-30 2023-06-01 10X Genomics, Inc. Systems and methods for identifying regions of aneuploidy in a tissue
CN117813390A (en) 2021-12-16 2024-04-02 因美纳有限公司 Method for metal directed cleavage of surface-bound polynucleotides
WO2023111727A1 (en) 2021-12-17 2023-06-22 3M Innovative Properties Company Articles with photoiniferter attached to inorganic oxide surface and polymers prepared therefrom
CN117813399A (en) 2021-12-20 2024-04-02 因美纳有限公司 Periodate compositions and methods for chemically cleaving surface-bound polynucleotides
CN117940577A (en) 2021-12-20 2024-04-26 因美纳有限公司 Periodate compositions and methods for chemically cleaving surface-bound polynucleotides
CN114316132B (en) * 2022-01-28 2023-08-01 赛纳生物科技(北京)有限公司 Method for synthesizing functional polymer microsphere by emulsion polymerization
WO2023159028A1 (en) 2022-02-15 2023-08-24 10X Genomics, Inc. Systems and methods for spatial analysis of analytes using fiducial alignment
CA3222807A1 (en) 2022-03-22 2023-09-28 Alexandra SZEMJONOV Substrate with orthogonally functional nanodomains
CA3223115A1 (en) 2022-03-28 2023-10-05 Xiaolin Wu Labeled avidin and methods for sequencing
US20230313292A1 (en) 2022-03-29 2023-10-05 Illumina Cambridge Limited Chromenoquinoline dyes and uses in sequencing
US20230313294A1 (en) 2022-03-30 2023-10-05 Illumina Cambridge Limited Methods for chemical cleavage of surface-bound polynucleotides
US20230332197A1 (en) 2022-03-31 2023-10-19 Illumina Singapore Pte. Ltd. Nucleosides and nucleotides with 3' vinyl blocking group
CA3223128A1 (en) 2022-03-31 2023-10-05 Illumina, Inc. Compositions and methods for improving sequencing signals
WO2023212532A1 (en) 2022-04-26 2023-11-02 10X Genomics, Inc. Systems and methods for evaluating biological samples
US20230383342A1 (en) 2022-05-31 2023-11-30 Illumina Cambridge Limited Compositions and methods for nucleic acid sequencing
CN115010852B (en) * 2022-06-01 2023-10-10 郑州玛特瑞斯生物科技有限公司 Polymer for surface modification of sequencing chip, sequencing chip and surface modification method thereof
WO2024003087A1 (en) 2022-06-28 2024-01-04 Illumina, Inc. Fluorescent dyes containing fused tetracyclic bis-boron heterocycle and uses in sequencing
WO2024025806A1 (en) 2022-07-27 2024-02-01 Illumina, Inc. Motion feedback using patterned flowcells
WO2024031068A1 (en) 2022-08-05 2024-02-08 10X Genomics, Inc. Systems and methods for immunofluorescence quantification
WO2024036191A1 (en) 2022-08-10 2024-02-15 10X Genomics, Inc. Systems and methods for colocalization
WO2024039516A1 (en) 2022-08-19 2024-02-22 Illumina, Inc. Third dna base pair site-specific dna detection
WO2024064639A1 (en) 2022-09-19 2024-03-28 Illumina, Inc. Nanogel particles having dual functionality and temperature responsiveness for particle clustering in nucleic acid sequencing systems
US20240100518A1 (en) 2022-09-26 2024-03-28 Illumina, Inc. Flow cell based motion system calibration and control methods
WO2024068889A2 (en) 2022-09-30 2024-04-04 Illumina, Inc. Compositions and methods for reducing photo damage during sequencing
WO2024112703A1 (en) 2022-11-21 2024-05-30 Illumina, Inc. Reversibly cross-linked hydrogels, and methods of using the same for cluster amplification
WO2024123748A1 (en) 2022-12-07 2024-06-13 Illumina, Inc. Etch-free photoresist patterning in multi-depth nanowells
US20240240217A1 (en) 2022-12-09 2024-07-18 Illumina, Inc. Nucleosides and nucleotides with 3' blocking groups and cleavable linkers
WO2024138050A1 (en) * 2022-12-21 2024-06-27 The Broad Institute, Inc. Single-nucleus high-resolution multi-modal spatial genomics
WO2024137765A1 (en) 2022-12-22 2024-06-27 Illumina, Inc. Transition-metal catalyst compositions and methods for sequencing by synthesis
US20240247311A1 (en) 2022-12-22 2024-07-25 Illumina, Inc. Palladium catalyst compositions and methods for sequencing by synthesis
WO2024145154A1 (en) 2022-12-27 2024-07-04 Illumina, Inc. Methods of sequencing using 3´ allyl blocked nucleotides
US20240257320A1 (en) 2023-01-27 2024-08-01 Illumina, Inc. Jitter correction image analysis

Family Cites Families (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54135525A (en) * 1978-04-12 1979-10-20 Konishiroku Photo Ind Co Ltd Photosensitive material
DE3706890A1 (en) 1987-03-04 1988-09-15 Bayer Ag OPTICALLY ACTIVE (METH) ACRYLAMID, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR RACEMATE CLEAVING
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
JPH0237350A (en) * 1988-07-28 1990-02-07 Nippon Kayaku Co Ltd Photosensitive resin composition
GB8822228D0 (en) 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
US5212253A (en) 1989-04-18 1993-05-18 Eastman Kodak Company Electrophoresis element comprising a polymer containing a haloacetamido group
US6346413B1 (en) 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
DE3924454A1 (en) 1989-07-24 1991-02-07 Cornelis P Prof Dr Hollenberg THE APPLICATION OF DNA AND DNA TECHNOLOGY FOR THE CONSTRUCTION OF NETWORKS FOR USE IN CHIP CONSTRUCTION AND CHIP PRODUCTION (DNA CHIPS)
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
CA2044616A1 (en) 1989-10-26 1991-04-27 Roger Y. Tsien Dna sequencing
US5223414A (en) 1990-05-07 1993-06-29 Sri International Process for nucleic acid hybridization and amplification
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
CA2118806A1 (en) 1991-09-18 1993-04-01 William J. Dower Method of synthesizing diverse collections of oligomers
US5677195A (en) 1991-11-22 1997-10-14 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis
DE69333650T2 (en) 1992-02-19 2006-01-12 The Public Health Research Institute Of The City Of New York, Inc. NEW ARRANGEMENT OF OLIGONUCLEOTIDES AND THEIR BENEFITS FOR SORTING, ISOLATING, SEQUENCING AND MANIPULATING NUCLEIC ACIDS
US5583211A (en) 1992-10-29 1996-12-10 Beckman Instruments, Inc. Surface activated organic polymers useful for location - specific attachment of nucleic acids, peptides, proteins and oligosaccharides
US5472672A (en) 1993-10-22 1995-12-05 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
US6156501A (en) 1993-10-26 2000-12-05 Affymetrix, Inc. Arrays of modified nucleic acid probes and methods of use
EP0730663B1 (en) 1993-10-26 2003-09-24 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5429807A (en) 1993-10-28 1995-07-04 Beckman Instruments, Inc. Method and apparatus for creating biopolymer arrays on a solid support surface
JPH09510351A (en) 1994-03-16 1997-10-21 ジェン−プローブ・インコーポレイテッド Isothermal strand displacement nucleic acid amplification method
US5552278A (en) 1994-04-04 1996-09-03 Spectragen, Inc. DNA sequencing by stepwise ligation and cleavage
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5641658A (en) 1994-08-03 1997-06-24 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid with two primers bound to a single solid support
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5750341A (en) 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5783502A (en) * 1995-06-07 1998-07-21 Bsi Corporation Virus inactivating coatings
WO1997004131A1 (en) 1995-07-21 1997-02-06 Forsyth Dental Infirmary For Children Single primer amplification of polynucleotide hairpins
CA2227895C (en) 1995-10-11 2012-07-17 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US5658734A (en) 1995-10-17 1997-08-19 International Business Machines Corporation Process for synthesizing chemical compounds
US6458530B1 (en) 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
JP2001509828A (en) 1997-01-08 2001-07-24 プロリゴ・エルエルシー Bioconjugation of macromolecules
US6297006B1 (en) 1997-01-16 2001-10-02 Hyseq, Inc. Methods for sequencing repetitive sequences and for determining the order of sequence subfragments
WO1998044152A1 (en) 1997-04-01 1998-10-08 Glaxo Group Limited Method of nucleic acid sequencing
EP3034626A1 (en) 1997-04-01 2016-06-22 Illumina Cambridge Limited Method of nucleic acid sequencing
US5948621A (en) 1997-09-30 1999-09-07 The United States Of America As Represented By The Secretary Of The Navy Direct molecular patterning using a micro-stamp gel
US5858653A (en) 1997-09-30 1999-01-12 Surmodics, Inc. Reagent and method for attaching target molecules to a surface
US6465178B2 (en) * 1997-09-30 2002-10-15 Surmodics, Inc. Target molecule attachment to surfaces
US6511803B1 (en) 1997-10-10 2003-01-28 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6485944B1 (en) 1997-10-10 2002-11-26 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6087102A (en) 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US7427678B2 (en) 1998-01-08 2008-09-23 Sigma-Aldrich Co. Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
US6287776B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Method for detecting and classifying nucleic acid hybridization
JP3944996B2 (en) 1998-03-05 2007-07-18 株式会社日立製作所 DNA probe array
AU4218499A (en) 1998-05-27 1999-12-13 Syntrix Biochip Light-mediated method and apparatus for the regional analysis of biologic material
US6031078A (en) 1998-06-16 2000-02-29 Millennium Pharmaceuticals, Inc. MTbx protein and nucleic acid molecules and uses therefor
JP2002521064A (en) 1998-07-30 2002-07-16 ソレックサ リミテッド Array biomolecules and their use in sequencing
AR021833A1 (en) 1998-09-30 2002-08-07 Applied Research Systems METHODS OF AMPLIFICATION AND SEQUENCING OF NUCLEIC ACID
US6277628B1 (en) 1998-10-02 2001-08-21 Incyte Genomics, Inc. Linear microarrays
US6391937B1 (en) 1998-11-25 2002-05-21 Motorola, Inc. Polyacrylamide hydrogels and hydrogel arrays made from polyacrylamide reactive prepolymers
WO2000046408A1 (en) 1999-02-04 2000-08-10 Sloan-Kettering Institute For Cancer Research Process for dna replication
US6699693B1 (en) 1999-02-04 2004-03-02 Sloan-Kettering Institute For Cancer Research Process for DNA replication
US20050191698A1 (en) 1999-04-20 2005-09-01 Illumina, Inc. Nucleic acid sequencing using microsphere arrays
WO2000063437A2 (en) 1999-04-20 2000-10-26 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US6221635B1 (en) 1999-05-06 2001-04-24 The Wistar Institute Methods for solid-phase amplification of DNA template (SPADT) using multiarrays
US6664061B2 (en) 1999-06-25 2003-12-16 Amersham Biosciences Ab Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix
US6372813B1 (en) 1999-06-25 2002-04-16 Motorola Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
KR20020048425A (en) 1999-09-30 2002-06-22 해리 제이. 레온 하르트 Biomolecular attachment sites on microelectronic arrays
US6077674A (en) 1999-10-27 2000-06-20 Agilent Technologies Inc. Method of producing oligonucleotide arrays with features of high purity
US6913884B2 (en) 2001-08-16 2005-07-05 Illumina, Inc. Compositions and methods for repetitive use of genomic DNA
DK1259643T3 (en) 2000-02-07 2009-02-23 Illumina Inc Method for Detecting Nucleic Acid Using Universal Priming
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
WO2001062982A2 (en) 2000-02-25 2001-08-30 Mosaic Technologies, Inc. Methods for multi-stage solid phase amplification of nucleic acids
US6410643B1 (en) 2000-03-09 2002-06-25 Surmodics, Inc. Solid phase synthesis method and reagent
AU2001282881B2 (en) 2000-07-07 2007-06-14 Visigen Biotechnologies, Inc. Real-time sequence determination
AU2001279244A1 (en) 2000-08-09 2002-02-18 Motorola, Inc. The use and evaluation of a (2+2) photocycloaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix
JP2004518138A (en) 2000-10-26 2004-06-17 バイオセプト インコーポレイテッド 3D biochip
WO2002044425A2 (en) 2000-12-01 2002-06-06 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
FR2817968B1 (en) 2000-12-07 2003-03-21 Bio Merieux DEVICE FOR CAPTURING A TARGET MOLECULE
AR031640A1 (en) 2000-12-08 2003-09-24 Applied Research Systems ISOTHERMAL AMPLIFICATION OF NUCLEIC ACIDS IN A SOLID SUPPORT
EP2801624B1 (en) 2001-03-16 2019-03-06 Singular Bio, Inc Arrays and methods of use
EP1386006B1 (en) 2001-04-20 2008-05-28 The Penn State Research Foundation Methods for nucleic acid manipulation
CA2450814A1 (en) 2001-07-02 2003-07-17 The Board Of Trustees Of The Leland Stanford Junior University Microarrays for cell phenotyping and manipulation
US6989267B2 (en) 2001-07-02 2006-01-24 Agilent Technologies, Inc. Methods of making microarrays with substrate surfaces having covalently bound polyelectrolyte films
JPWO2003014394A1 (en) 2001-08-03 2004-11-25 旭メディカル株式会社 Biocompatibility evaluation method
WO2003035278A1 (en) 2001-10-25 2003-05-01 Massachusetts Institute Of Technology Method of depositing polyelectrolyte multilayers and articles coated thereby
GB0127564D0 (en) 2001-11-16 2002-01-09 Medical Res Council Emulsion compositions
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
US7399590B2 (en) 2002-02-21 2008-07-15 Asm Scientific, Inc. Recombinase polymerase amplification
US20040002090A1 (en) 2002-03-05 2004-01-01 Pascal Mayer Methods for detecting genome-wide sequence variations associated with a phenotype
AU2003208480A1 (en) 2002-03-05 2003-09-16 Lynx Therapeutics INC. Methods for detecting genome-wide sequence variations associated with a phenotype
DK2226316T3 (en) 2002-05-30 2016-04-11 Scripps Research Inst Copper catalyzed ligation of azides and acetylenes
EP1515800A1 (en) 2002-06-27 2005-03-23 Akzo Nobel N.V. Adsorbent material and method of preparing an adsorbent material
SI3363809T1 (en) 2002-08-23 2020-08-31 Illumina Cambridge Limited Modified nucleotides for polynucleotide sequencing
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
WO2005003375A2 (en) 2003-01-29 2005-01-13 454 Corporation Methods of amplifying and sequencing nucleic acids
ATE448866T1 (en) 2003-02-19 2009-12-15 Natrix Separations Inc SUPPORTED POROUS GELS COMPRISING COMPOSITE MATERIALS
US9045796B2 (en) 2003-06-20 2015-06-02 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
EP1641809B2 (en) 2003-07-05 2018-10-03 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
US7309593B2 (en) * 2003-10-01 2007-12-18 Surmodics, Inc. Attachment of molecules to surfaces
GB0326073D0 (en) 2003-11-07 2003-12-10 Solexa Ltd Improvements in or relating to polynucleotide arrays
EP2789383B1 (en) 2004-01-07 2023-05-03 Illumina Cambridge Limited Molecular arrays
CN101103357B (en) 2004-08-13 2012-10-03 哈佛学院院长等 An ultra high-throughput opti-nanopore DNA readout platform
EP3415641B1 (en) 2004-09-17 2023-11-01 Pacific Biosciences Of California, Inc. Method for analysis of molecules
US8445194B2 (en) 2005-06-15 2013-05-21 Callida Genomics, Inc. Single molecule arrays for genetic and chemical analysis
CA2616241C (en) 2005-07-25 2012-02-07 Asm Scientific, Inc. Methods for multiplexing recombinase polymerase amplification
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
EP2021503A1 (en) 2006-03-17 2009-02-11 Solexa Ltd. Isothermal methods for creating clonal single molecule arrays
EP4105644A3 (en) 2006-03-31 2022-12-28 Illumina, Inc. Systems and devices for sequence by synthesis analysis
EP3088533B1 (en) 2006-05-04 2018-01-17 Alere San Diego, Inc. Recombinase polymerase amplification
AU2007309504B2 (en) 2006-10-23 2012-09-13 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
EP2677308B1 (en) 2006-12-14 2017-04-26 Life Technologies Corporation Method for fabricating large scale FET arrays
WO2008093098A2 (en) 2007-02-02 2008-08-07 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
EP2173467B1 (en) 2007-07-13 2016-05-04 The Board Of Trustees Of The Leland Stanford Junior University Method and apparatus using electric field for improved biological assays
WO2009073702A1 (en) * 2007-12-04 2009-06-11 E. I. Du Pont De Nemours And Company Decarboxylating block copolymers
WO2009099126A1 (en) * 2008-02-07 2009-08-13 Riken Photoreactive copolymer, surface modifier, hydrophilic treatment agent, adsorption inhibitor, substance-immobilizing agent, surface modification method, hydrophilization method, adsorption inhibition method, and substance-immobilizing method
CN101514956B (en) * 2008-08-18 2011-06-22 北京九州泰康生物科技有限责任公司 Molecule detecting system
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US9309557B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Nucleic acid amplification
CA2786195A1 (en) * 2010-01-11 2011-07-14 Clariant Finance (Bvi) Limited Surface coatings having anti-ice properties
GB2482122B (en) 2010-07-19 2014-02-19 Intellectual Ventures Holding 81 Llc Communication unit and pilot method for time varying channels
EP2632593B1 (en) 2010-10-27 2021-09-29 Illumina, Inc. Flow cells for biological or chemical analysis
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
WO2012106072A2 (en) 2011-02-03 2012-08-09 Illumina, Inc. Methods for minimizing sequence specific bias
JP5818245B2 (en) * 2011-03-25 2015-11-18 国立研究開発法人物質・材料研究機構 Isopropyl acrylamide derivative having azide group or alkyne group and polymer thereof
WO2012170936A2 (en) * 2011-06-09 2012-12-13 Illumina, Inc. Patterned flow-cells useful for nucleic acid analysis
CA2856163C (en) 2011-10-28 2019-05-07 Illumina, Inc. Microarray fabrication system and method
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
US8895249B2 (en) 2012-06-15 2014-11-25 Illumina, Inc. Kinetic exclusion amplification of nucleic acid libraries

Also Published As

Publication number Publication date
US9012022B2 (en) 2015-04-21
US20140079923A1 (en) 2014-03-20
EP2859055A1 (en) 2015-04-15
US20210254151A1 (en) 2021-08-19
CN108165119A (en) 2018-06-15
IL236023B (en) 2018-02-28
EP3792320A1 (en) 2021-03-17
US12060609B2 (en) 2024-08-13
ES2859823T3 (en) 2021-10-04
BR112014030465A8 (en) 2021-04-13
AU2013271677A1 (en) 2015-01-29
US10954561B2 (en) 2021-03-23
EP2859055B1 (en) 2020-12-23
JP6449395B2 (en) 2019-01-09
US20150259735A1 (en) 2015-09-17
US20230357846A1 (en) 2023-11-09
AU2013271677B2 (en) 2015-05-07
JP2016027959A (en) 2016-02-25
PT2859055T (en) 2021-03-12
JP6204955B2 (en) 2017-09-27
PL2859055T3 (en) 2021-07-05
KR101559983B1 (en) 2015-10-13
US20170342487A1 (en) 2017-11-30
US9752186B2 (en) 2017-09-05
JP2017213913A (en) 2017-12-07
IL236023A0 (en) 2015-01-29
CN104508060B (en) 2018-01-30
CA2875671A1 (en) 2013-12-12
CN108165119B (en) 2020-09-04
CN104508060A (en) 2015-04-08
DK2859055T3 (en) 2021-02-22
US20190233890A1 (en) 2019-08-01
BR112014030465A2 (en) 2017-06-27
CA2875671C (en) 2015-10-13
JP5859172B2 (en) 2016-02-10
HK1208697A1 (en) 2016-03-11
US10266891B2 (en) 2019-04-23
US11702694B2 (en) 2023-07-18
WO2013184796A1 (en) 2013-12-12
KR20150016634A (en) 2015-02-12
JP2015529576A (en) 2015-10-08

Similar Documents

Publication Publication Date Title
IN2014DN11101A (en)
WO2012094492A3 (en) Combinatorial dna taggants and methods of preparation and use thereof
EP4242321A3 (en) De novo synthesized gene libraries
WO2013101902A3 (en) Chromophoric polymer dots with narrow-band emission
WO2010039247A3 (en) Substrates with surfaces modified with peg
WO2012054525A3 (en) Chromophoric polymer dots
WO2013082488A3 (en) Optical coating method, apparatus and product
EP2868698A4 (en) Conductive polymer composition, coated article which is provided with antistatic film obtained from conductive polymer composition, and pattern forming method using conductive polymer composition
MX2010001629A (en) Polymer hydrogels and methods of preparation thereof.
WO2014160906A3 (en) Urethane based polymeric extenders for compositions to modify the surface properties of substrates
PL2350209T3 (en) Carbon particles coated with polymer films, methods for their production and uses thereof
EP2292691A4 (en) Organic-inorganic complex dispersion, cell culture substratum manufactured by using the dispersion, and manufacturing methods for same
TW200724616A (en) Compositions containing a silanol functional polymer and related hydrophilic coating films
WO2018118997A3 (en) Polymerizing enzymes for sequencing reactions
WO2012103238A8 (en) Polyimide polymer from non-stoichiometric components
GB2510079A (en) Flexible scratch resistance film for display devices
HK1159669A1 (en) Polymer with salt groups and antifouling coating composition comprising said polymer
WO2013056007A3 (en) Photochemical cross-linkable polymers, methods of making photochemical cross-linkable plolymers, methods of using photochemical cross-linkable poloymers, and methods of making articles containing photochemical cross-linkable polymers
MY175930A (en) Coating method using particle alignment and particle coated substrate manufactured thereby
HK1197226A1 (en) Hybrid polymer coating for petrous or ceramic substrates, petrous or ceramic substrate, and obtaining method
WO2012145574A3 (en) Methods, compositions and systems for sample deposition
JP2010022366A5 (en)
WO2012027218A3 (en) Peptide-modified surfaces for cell culture
WO2013049095A3 (en) Catalyzing amino-substituted organosilane ester primers
WO2009111049A3 (en) Method of imparting corrosion resistance to a substrate surface, and coated substrates prepared thereby