IN2014DN11074A - - Google Patents

Info

Publication number
IN2014DN11074A
IN2014DN11074A IN11074DEN2014A IN2014DN11074A IN 2014DN11074 A IN2014DN11074 A IN 2014DN11074A IN 11074DEN2014 A IN11074DEN2014 A IN 11074DEN2014A IN 2014DN11074 A IN2014DN11074 A IN 2014DN11074A
Authority
IN
India
Prior art keywords
permeability material
magnetic permeability
magnetizable layer
magnets
high magnetic
Prior art date
Application number
Inventor
Kyle C Smith
Ramin Haghoogie
Thomas Alan Barber
Ismail Emre Ozkumur
Ravi Kapur
Mehmet Toner
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Publication of IN2014DN11074A publication Critical patent/IN2014DN11074A/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B03C1/031—Component parts; Auxiliary operations
    • B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0332—Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48735—Investigating suspensions of cells, e.g. measuring microbe concentration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/22—Details of magnetic or electrostatic separation characterised by the magnetic field, e.g. its shape or generation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Fluid Mechanics (AREA)
  • Clinical Laboratory Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

This disclosure describes microfluidic devices that include one or more magnets each magnet being operable to emit a magnetic field; and a magnetizable layer adjacent to the one or more magnets in which the magnetizable layer is configured to induce a gradient in the magnetic field of at least one of the magnets. For example the gradient can be at least 10T/m at a position that is at least 20 µm away from a surface of the magnetizable layer. The magnetizable layer includes a first high magnetic permeability material and a low magnetic permeability material arranged adjacent to the high magnetic permeability material. The devices also include a microfluidic channel arranged on a surface of the magnetizable layer wherein a central longitudinal axis of the microfluidic channel is arranged at an angle to or laterally offset from an interface between the high magnetic permeability material and the low magnetic permeability material.
IN11074DEN2014 2012-06-25 2013-06-25 IN2014DN11074A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261664051P 2012-06-25 2012-06-25
PCT/US2013/047710 WO2014004577A1 (en) 2012-06-25 2013-06-25 Sorting particles using high gradient magnetic fields

Publications (1)

Publication Number Publication Date
IN2014DN11074A true IN2014DN11074A (en) 2015-09-25

Family

ID=49783810

Family Applications (1)

Application Number Title Priority Date Filing Date
IN11074DEN2014 IN2014DN11074A (en) 2012-06-25 2013-06-25

Country Status (6)

Country Link
US (3) US9278353B2 (en)
EP (1) EP2864051B1 (en)
JP (1) JP6382188B2 (en)
CN (1) CN104540594B (en)
IN (1) IN2014DN11074A (en)
WO (1) WO2014004577A1 (en)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014004577A1 (en) 2012-06-25 2014-01-03 The General Hospital Corporation Sorting particles using high gradient magnetic fields
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
CN110186835B (en) 2013-03-15 2022-05-31 Gpb科学有限公司 On-chip microfluidic processing of particles
US20160299132A1 (en) 2013-03-15 2016-10-13 Ancera, Inc. Systems and methods for bead-based assays in ferrofluids
US20160296945A1 (en) 2013-03-15 2016-10-13 Ancera, Inc. Systems and methods for active particle separation
CN105247042B (en) 2013-03-15 2021-06-11 普林斯顿大学理事会 Method and apparatus for high throughput purification
US10202577B2 (en) 2013-10-18 2019-02-12 The General Hospital Corporation Microfluidic sorting using high gradient magnetic fields
IL247445B (en) 2014-02-26 2022-07-01 Brigham & Womens Hospital Inc System and method for gliding cells and monitoring
CA2966623C (en) 2014-11-03 2024-02-20 The General Hospital Corporation Concentrating particles in a microfluidic device
US10729879B2 (en) 2015-02-27 2020-08-04 Purdue Research Foundation Self-clearing catheters and methods of use thereof
US11285490B2 (en) 2015-06-26 2022-03-29 Ancera, Llc Background defocusing and clearing in ferrofluid-based capture assays
US10976232B2 (en) 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
EP3341893A4 (en) * 2015-08-24 2019-03-06 GPB Scientific, LLC METHODS AND DEVICES FOR PURIFICATION AND CONCENTRATION OF MULTI-STEP CELLS
US10809180B2 (en) * 2015-09-28 2020-10-20 The Governing Council Of The University Of Toronto Device for magnetic profiling of particles in a flow
CA3000010C (en) 2015-10-02 2025-05-06 The Board Of Trustees Of The Leland Stanford Junior University Sorting biological and non-biological moieties using magnetic levitation
JP6889169B2 (en) * 2016-02-03 2021-06-18 アダプタス ソリューションズ プロプライエタリー リミテッド Devices and methods for controlling charged particles in a magnetic field
JP6738066B2 (en) * 2016-08-08 2020-08-12 国立研究開発法人産業技術総合研究所 Extraction filter and immunochromatographic analysis kit including the same
GB2552841B (en) * 2016-08-12 2020-05-20 Thermo Fisher Scient Bremen Gmbh Method of calibrating a mass spectrometer
JP6759881B2 (en) * 2016-09-05 2020-09-23 アイシン精機株式会社 Manufacturing method of biomolecule detection device and biomolecule detection device
CN107233941B (en) * 2017-04-24 2019-11-26 深圳无微华斯生物科技有限公司 A kind of multiple near-infrared fluorescent enhancing biochip screening circulating tumor cell method
CN117143960A (en) 2017-05-18 2023-12-01 10X基因组学有限公司 Methods and systems for sorting droplets and beads
US10544413B2 (en) 2017-05-18 2020-01-28 10X Genomics, Inc. Methods and systems for sorting droplets and beads
GB201711804D0 (en) * 2017-07-21 2017-09-06 Mast Group Ltd Apparatus for conducting an assay
US11292000B2 (en) 2017-08-04 2022-04-05 University Of Georgia Research Foundation, Inc. Devices and methods for separating circulating tumor cells from biological samples
US11648559B2 (en) 2017-08-04 2023-05-16 University Of Georgia Research Foundation, Inc. Devices and methods for separating circulating tumor cells from biological samples
EP3669163A4 (en) * 2017-08-04 2021-08-11 University of Georgia Research Foundation, Inc. DEVICES AND METHODS FOR SEPARATING CIRCULATING TUMOR CELLS FROM BIOLOGICAL SAMPLES
US10610865B2 (en) 2017-08-22 2020-04-07 10X Genomics, Inc. Droplet forming devices and system with differential surface properties
JP7393328B2 (en) 2017-09-01 2023-12-06 ジーピービー・サイエンティフィック・インコーポレイテッド Methods for preparing therapeutically active cells using microfluidics
WO2019083852A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. Microfluidic channel networks for partitioning
CN107845477A (en) * 2017-11-24 2018-03-27 西安交通大学 A kind of controlling magnetic field generator screened for magnetic bionanoparticles particle diameter with being homogenized
CN111757928A (en) * 2017-12-01 2020-10-09 环球生命科技咨询美国有限责任公司 Methods for cell enrichment and isolation
EP3723908A4 (en) * 2017-12-12 2021-07-14 Ancera, LLC SYSTEMS, METHODS, AND DEVICES FOR MAGNETIC SCANNING FOR A FERROFLUID BASED TEST
WO2019169347A1 (en) 2018-03-02 2019-09-06 10X Genomics, Inc. Systems and apparatus for holding plates
US12564995B2 (en) 2019-01-31 2026-03-03 Illumina, Inc. Thermoformed, injection molded, and/or overmolded microfluidic structures and techniques for making the same
WO2020176882A1 (en) 2019-02-28 2020-09-03 10X Genomics, Inc. Devices, systems, and methods for increasing droplet formation efficiency
US12186751B2 (en) 2019-06-28 2025-01-07 10X Genomics, Inc. Devices and systems incorporating acoustic ordering and methods of use thereof
FR3100338B1 (en) * 2019-08-30 2022-09-02 Centre Nat Rech Scient Kit and method for capturing a molecule
US12059679B2 (en) 2019-11-19 2024-08-13 10X Genomics, Inc. Methods and devices for sorting droplets and particles
KR102491075B1 (en) * 2020-01-08 2023-01-27 주식회사 피엠랩 Magnetic separation device using permanent magnet and filter structure thereof
WO2021183687A2 (en) 2020-03-10 2021-09-16 Cellares Corporation Systems, devices, and methods for cell processing
CN111450803B (en) * 2020-03-16 2022-05-17 哈尔滨工业大学 Preparation method and application of magnetic covalent organic framework compound adsorbing triphenylmethane dyes
CN111778159B (en) * 2020-06-02 2023-01-31 东南大学 Multi-stage sorting micro-fluidic chip for cells
WO2022061528A1 (en) * 2020-09-22 2022-03-31 中国科学院深圳先进技术研究院 Magnetic sorting microfluidic chip and production method therefor
EP3978119A1 (en) * 2020-09-30 2022-04-06 Levitas, Inc. Particle separator system, materials, and methods of use
FR3116215B1 (en) * 2020-11-17 2024-03-29 Magia Diagnostics CARTRIDGE COMPRISING A PLURALITY OF ANALYSIS CHAMBERS TO RECEIVE A BIOLOGICAL LIQUID
US20240094106A1 (en) * 2021-02-03 2024-03-21 University Of Georgia Research Foundation, Inc. Devices, kits, and methods for label-free inertial ferrohydrodynamic cell separation with high throughput and resolution
CN113109107B (en) * 2021-03-24 2022-06-07 西安交通大学 Enrichment device of aerosol particles
US20250161942A1 (en) * 2022-01-21 2025-05-22 Trustees Of Dartmouth College Microtransfer patterning of magnetic materials for microfluidic applications
EP4402192B1 (en) 2022-08-18 2025-07-02 10X Genomics, Inc. Droplet forming devices and methods having flourous diol additives
CN116251770B (en) * 2023-03-15 2024-05-24 鸿翔环境科技股份有限公司 Magnetic fluid sorting equipment and method for construction waste
US12399193B2 (en) 2023-05-05 2025-08-26 Cellares Corporation Systems, devices, and methods for combined cell processes
WO2025041064A2 (en) * 2023-08-21 2025-02-27 Cellares Corporation Systems, devices, and methods for automatic cell sorting
US12497587B2 (en) 2023-08-21 2025-12-16 Cellares Corporation Bioreactors and methods of their use in automatic cell processing systems

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU810277A1 (en) 1979-04-06 1981-03-07 Предприятие П/Я В-2126 Magnetizing apparatus
US5972721A (en) * 1996-03-14 1999-10-26 The United States Of America As Represented By The Secretary Of The Air Force Immunomagnetic assay system for clinical diagnosis and other purposes
US20050287583A1 (en) * 1997-01-21 2005-12-29 Promega Corporation Methods and kits for isolating biological target materials using silica magnetic particles
US6027945A (en) * 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
US5968820A (en) 1997-02-26 1999-10-19 The Cleveland Clinic Foundation Method for magnetically separating cells into fractionated flow streams
US6540896B1 (en) 1998-08-05 2003-04-01 Caliper Technologies Corp. Open-Field serial to parallel converter
CN1181337C (en) * 2000-08-08 2004-12-22 清华大学 Method for manipulating solid molecules in microfluidic system and related kits
TW496775B (en) * 1999-03-15 2002-08-01 Aviva Bioscience Corp Individually addressable micro-electromagnetic unit array chips
US6858439B1 (en) * 1999-03-15 2005-02-22 Aviva Biosciences Compositions and methods for separation of moieties on chips
CN1185492C (en) * 1999-03-15 2005-01-19 清华大学 Micro-electromagnetic unit array chip capable of single-point gating, electromagnetic biological chip and application
PT1169062E (en) 1999-04-09 2009-12-17 Amag Pharmaceuticals Inc Heat stable coated colloidal iron oxides
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
DE60113287D1 (en) * 2000-06-14 2005-10-13 Univ Texas SYSTEMS AND METHOD FOR CELL PARTIAL POPULATION ANALYSIS
AU2002320058A1 (en) 2001-06-06 2002-12-16 The General Hspital Corporation Magnetic-nanoparticle conjugates and methods of use
US7285412B2 (en) * 2001-07-27 2007-10-23 Surface Logix Inc. Device for magnetic immobilization of cells
US20030124194A1 (en) 2002-01-02 2003-07-03 Gaw Debra A. Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor
US20060041182A1 (en) * 2003-04-16 2006-02-23 Forbes Zachary G Magnetically-controllable delivery system for therapeutic agents
JP2006012529A (en) * 2004-06-24 2006-01-12 Dainippon Ink & Chem Inc Fuel cell separator manufacturing apparatus and fuel cell separator manufacturing method
JP2006010529A (en) * 2004-06-25 2006-01-12 Canon Inc Magnetic particle separation device and separation method
DE102004040785B4 (en) * 2004-08-23 2006-09-21 Kist-Europe Forschungsgesellschaft Mbh Microfluidic system for the isolation of biological particles using immunomagnetic separation
CA2606924C (en) 2005-05-09 2013-04-16 The General Hospital Corporation Water relaxation-based sensors
US20060292013A1 (en) * 2005-06-02 2006-12-28 Love Lonnie J Magnetocaloric pump for microfluidic applications
US9220831B2 (en) * 2005-10-06 2015-12-29 Children's Medical Center Corporation Device and method for combined microfluidic-micromagnetic separation of material in continuous flow
KR100846491B1 (en) 2006-07-25 2008-07-17 삼성전자주식회사 Magnetic Bead Extraction Device for Isolation and Purification of Target Biomolecules in Microfluidic Devices
US7807454B2 (en) * 2006-10-18 2010-10-05 The Regents Of The University Of California Microfluidic magnetophoretic device and methods for using the same
RU68497U1 (en) 2006-12-06 2007-11-27 Владимир Евгеньевич Ляховецкий DEVICE FOR MAGNETIC TREATMENT OF A FLOW OF ORGANIC OR INORGANIC LIQUID OR GAS
KR101503510B1 (en) * 2007-02-09 2015-03-18 어드밴스드 리퀴드 로직, 아이엔씨. Droplet actuator devices and methods employing magnetic beads
EP2562531A3 (en) 2007-04-16 2013-03-06 The General Hospital Corporation d/b/a Massachusetts General Hospital Systems and methods for particle focusing in microchannels
WO2008147530A1 (en) * 2007-05-24 2008-12-04 The Regents Of The University Of California Integrated fluidics devices with magnetic sorting
EP2167216B1 (en) * 2007-06-29 2012-05-02 The President and Fellows of Harvard College Density-based methods for separation of materials, monitoring of solid supported reactions and measuring densities of small liquid volumes and solids
US7837379B2 (en) * 2007-08-13 2010-11-23 The Charles Stark Draper Laboratory, Inc. Devices for producing a continuously flowing concentration gradient in laminar flow
WO2009045551A1 (en) 2007-10-04 2009-04-09 The General Hospital Corporation Miniaturized magnetic resonance systems and methods
WO2009132151A2 (en) 2008-04-23 2009-10-29 The Regents Of The University Of California Microfluidic devices and methods of using same
KR100990170B1 (en) * 2008-10-09 2010-10-29 충북대학교 산학협력단 Piezoelectric pump
JP2010151777A (en) * 2008-11-19 2010-07-08 Sony Corp Microparticle analyzer, microchip, and method for analyzing microparticle
KR101030637B1 (en) 2009-02-02 2011-04-20 포항공과대학교 산학협력단 Surface Defect Inspection System
US8417115B2 (en) 2009-07-09 2013-04-09 Finisar Corporation Quantifying link quality in an optoelectronic module
DE102009047801B4 (en) * 2009-09-30 2014-06-12 Siemens Aktiengesellschaft Flow chamber with cell guide
US20110123783A1 (en) * 2009-11-23 2011-05-26 David Sherrer Multilayer build processses and devices thereof
WO2011103143A1 (en) * 2010-02-16 2011-08-25 The University Of North Carolina At Chapel Hill Array of micromolded structures for sorting adherent cells
KR20120026959A (en) * 2010-09-10 2012-03-20 인제대학교 산학협력단 Microparticle separator based on magnetophoresis and microparticle separating method using the same
WO2012054639A2 (en) * 2010-10-22 2012-04-26 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
KR101286939B1 (en) 2011-04-21 2013-07-16 차희장 Imitation stone panel
WO2014004577A1 (en) 2012-06-25 2014-01-03 The General Hospital Corporation Sorting particles using high gradient magnetic fields

Also Published As

Publication number Publication date
US9878327B2 (en) 2018-01-30
EP2864051A1 (en) 2015-04-29
JP2015529544A (en) 2015-10-08
US9278353B2 (en) 2016-03-08
US20190030535A1 (en) 2019-01-31
EP2864051A4 (en) 2016-04-06
US20150336096A1 (en) 2015-11-26
EP2864051B1 (en) 2020-09-23
US20160263574A1 (en) 2016-09-15
CN104540594B (en) 2019-07-02
JP6382188B2 (en) 2018-08-29
WO2014004577A1 (en) 2014-01-03
HK1209683A1 (en) 2016-04-08
CN104540594A (en) 2015-04-22
US10668470B2 (en) 2020-06-02

Similar Documents

Publication Publication Date Title
IN2014DN11074A (en)
EP3058316A4 (en) Microfluidic sorting using high gradient magnetic fields
MY162696A (en) Magnetic field downhole tool attachment
EP2954540A4 (en) Iron nitride permanent magnet and technique for forming iron nitride permanent magnet
BR112015032548A2 (en) IRON NITRIDE MATERIALS AND MAGNETS INCLUDING IRON NITRIDE MATERIALS
MY195755A (en) Magnetically Coupled Safety Valve With Satellite Inner Magnets
GB2532894B (en) Display member and base member magnetically attracted
WO2015134199A3 (en) System and method for reducing emissions for polarized coil systems for wireless inductive power transfer
EP2988279A4 (en) Magnetic head for detecting magnetic field on surface of magnetic pattern based on magneto-resistance technology
EP3027781A4 (en) Microfabricated magnetic field transducer with flux guide
EP3087573A4 (en) Rare earth permanent magnetic material and method of preparing the same
EP3131190A4 (en) Permanent magnet speed governor with fixed magnetic gap
PL3364426T3 (en) Ferrite magnetic material and ferrite sintered magnet
IN2014KO00928A (en)
EP2975152A4 (en) NON-DIRECTIONAL ELECTROMAGNETIC STEEL PLATE WITH EXCELLENT MAGNETIC CHARACTERISTICS
GB201720203D0 (en) Magnetic resonance visible labels and markers for encoding information
MX2016004757A (en) Ferrofluid tool for enhancing magnetic fields in a wellbore.
HUE055792T2 (en) Magnet and device for magnetic density separation
EP2942794A4 (en) PERMANENT MAGNET FOR MAGNETIC ANGLE ENCODER
GB2511048B (en) Methods and apparatus for compensating for drift in magnetic field strength in superconducting magnets
GB201708962D0 (en) Roller module having magnetic bearing and permanent magnet portion
FI20145101A7 (en) Magnet and method for handling metal sheets
EP2976653A4 (en) Nuclear magnetic resonance (nmr) interecho interval control methods and systems
EP2779163A3 (en) Non-Magnetic Seed Layer Method and Apparatus
WO2014093816A3 (en) Magnetically polarized photonic device