IN2014DN09127A - - Google Patents

Info

Publication number
IN2014DN09127A
IN2014DN09127A IN9127DEN2014A IN2014DN09127A IN 2014DN09127 A IN2014DN09127 A IN 2014DN09127A IN 9127DEN2014 A IN9127DEN2014 A IN 9127DEN2014A IN 2014DN09127 A IN2014DN09127 A IN 2014DN09127A
Authority
IN
India
Prior art keywords
propagation
light sheet
non diffractive
diffractive
optical system
Prior art date
Application number
Inventor
Kishan Dholakia
Tom Vettenburg
Original Assignee
Univ St Andrews
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1205974.7A external-priority patent/GB201205974D0/en
Priority claimed from GBGB1215169.2A external-priority patent/GB201215169D0/en
Application filed by Univ St Andrews filed Critical Univ St Andrews
Publication of IN2014DN09127A publication Critical patent/IN2014DN09127A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G02B21/08—Condensers
    • G02B21/10—Condensers affording dark-field illumination
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/09—Beam shaping, e.g. changing the cross-sectional area, not otherwise provided for
    • G02B27/0927—Systems for changing the beam intensity distribution, e.g. Gaussian to top-hat
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/09—Beam shaping, e.g. changing the cross-sectional area, not otherwise provided for
    • G02B27/0938—Using specific optical elements
    • G02B27/0944—Diffractive optical elements, e.g. gratings, holograms
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/09—Beam shaping, e.g. changing the cross-sectional area, not otherwise provided for
    • G02B27/0938—Using specific optical elements
    • G02B27/0988—Diaphragms, spatial filters, masks for removing or filtering a part of the beam
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/58—Optics for apodization or superresolution; Optical synthetic aperture systems
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N7/00—Television systems
    • H04N7/18—Closed-circuit television [CCTV] systems, i.e. systems in which the video signal is not broadcast
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Multimedia (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Signal Processing (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
  • Nonlinear Science (AREA)
  • Optical Elements Other Than Lenses (AREA)
  • Tents Or Canopies (AREA)

Abstract

A light sheet optical system comprising means for forming a light sheet using a non diffractive or quasi non diffractive and/or propagation invariant beam that has an asymmetric intensity beam profile transverse to the direction of propagation such as an Airy beam.
IN9127DEN2014 2012-04-03 2013-03-26 IN2014DN09127A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1205974.7A GB201205974D0 (en) 2012-04-03 2012-04-03 High resolution imaging of extended volumes
GBGB1215169.2A GB201215169D0 (en) 2012-08-24 2012-08-24 High resolution imaging of extended volumes
PCT/GB2013/050788 WO2013150273A1 (en) 2012-04-03 2013-03-26 High resolution imaging of extended volumes

Publications (1)

Publication Number Publication Date
IN2014DN09127A true IN2014DN09127A (en) 2015-05-22

Family

ID=48095913

Family Applications (1)

Application Number Title Priority Date Filing Date
IN9127DEN2014 IN2014DN09127A (en) 2012-04-03 2013-03-26

Country Status (8)

Country Link
US (1) US10444520B2 (en)
EP (1) EP2834695B1 (en)
JP (1) JP6166776B2 (en)
CN (1) CN104204898B (en)
CA (1) CA2869359C (en)
ES (1) ES2898616T3 (en)
IN (1) IN2014DN09127A (en)
WO (1) WO2013150273A1 (en)

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US7838302B2 (en) 2006-08-07 2010-11-23 President And Fellows Of Harvard College Sub-diffraction limit image resolution and other imaging techniques
EP4060327A1 (en) 2007-12-21 2022-09-21 President and Fellows of Harvard College Sub-diffraction limit image resolution in three dimensions
US9404869B2 (en) * 2012-10-09 2016-08-02 Howard Hughes Medical Institute Multiview light-sheet microscopy
DE102013208926A1 (en) * 2013-05-14 2014-11-20 Carl Zeiss Microscopy Gmbh Method for 3D high-resolution localization microscopy
US10539772B2 (en) 2013-10-09 2020-01-21 Howard Hughes Medical Institute Multiview light-sheet microscopy
DE102013112595A1 (en) * 2013-11-15 2015-05-21 Carl Zeiss Microscopy Gmbh Arrangement for light-sheet microscopy
DE102013021222B4 (en) * 2013-12-17 2023-05-04 Carl Zeiss Microscopy Gmbh Microscope and microscopy method
WO2015117115A1 (en) * 2014-02-03 2015-08-06 President And Fellows Of Harvard College Three-dimensional super-resolution fluorescence imaging using airy beams and other techniques
DE102014102215A1 (en) * 2014-02-20 2015-08-20 Carl Zeiss Microscopy Gmbh Method and arrangement for light-sheet microscopy
GB201413500D0 (en) * 2014-07-30 2014-09-10 Univ St Andrews Airy beam light sheet
DE102014113827A1 (en) * 2014-09-24 2016-03-24 Carl Zeiss Microscopy Gmbh Device for imaging a sample
CN104459971B (en) * 2014-12-24 2016-01-13 中国科学院半导体研究所 A kind of Structured Illumination micro imaging system based on integrated photon chip
GB201508376D0 (en) * 2015-05-15 2015-07-01 Univ St Andrews Light sheet imaging
WO2016188143A1 (en) * 2015-05-22 2016-12-01 The Hong Kong University Of Science And Technology Methods and systems for generating non-diffracting light sheets for multicolor fluorescence microscopy
DE102015209758A1 (en) * 2015-05-28 2016-12-01 Carl Zeiss Microscopy Gmbh Arrangement and method for beam shaping and light sheet microscopy
EP3341710B1 (en) * 2015-08-26 2022-02-16 The United States of America, as represented by The Secretary, Department of Health & Human Services Systems and methods for multi-view nonlinear optical imaging for improved signal-to-noise ratio and resolution in point scanning multi-photon microscopy
DE102016203671A1 (en) * 2016-03-07 2017-09-07 Carl Zeiss Microscopy Gmbh Method for determining a height information of a sample and a scanning microscope
DE102016108384B3 (en) 2016-05-04 2017-11-09 Leica Microsystems Cms Gmbh Device and method for light sheet-like illumination of a sample
CN105866013A (en) * 2016-05-26 2016-08-17 天津大学 Spherical particle distinguishing method based on two laser interference imaging out-of-focus interference patterns
WO2017223426A1 (en) * 2016-06-24 2017-12-28 Howard Hughes Medical Institute Automated adjustment of light sheet geometry in a microscope
CN106053346B (en) * 2016-06-29 2018-06-08 华中科技大学 A kind of mating plate micro-imaging conversion equipment
CN106153307B (en) * 2016-06-30 2018-09-28 河南科技大学 A kind of device and method measuring the Airy beam attenuation factors using beam intensity ratio
JP7109423B2 (en) * 2016-08-15 2022-07-29 ライカ マイクロシステムズ シーエムエス ゲゼルシャフト ミット ベシュレンクテル ハフツング light sheet microscope
CN111142251B (en) * 2016-10-26 2022-03-25 合肥百会拓知科技有限公司 Microscope with three-dimensional imaging capability and imaging method
US11506877B2 (en) 2016-11-10 2022-11-22 The Trustees Of Columbia University In The City Of New York Imaging instrument having objective axis and light sheet or light beam projector axis intersecting at less than 90 degrees
WO2018089948A1 (en) * 2016-11-11 2018-05-17 Cold Spring Harbor Laboratory System and method for light sheet microscope and clearing for tracing
RU2019138507A (en) * 2017-05-02 2021-06-02 Мерк Шарп И Доум Корп. ANTIBODY AGAINST LAG3 AND JOINT ANTIBODY AGAINST LAG3 AND ANTIBODY AGAINST PD-1
CN107238590A (en) * 2017-05-24 2017-10-10 清华大学 Based on the micro- microscopy tomography device being imaged with single pixel of mating plate
CN107144951B (en) * 2017-06-30 2023-03-21 中国计量大学 Super-resolution microscopic device based on hemispherical microstructure
CN108303402A (en) * 2017-12-26 2018-07-20 华中科技大学 A kind of micro- scan imaging method of big visual field salt free ligands Bezier mating plate and system
JP7228917B2 (en) * 2018-01-02 2023-02-27 キングス カレッジ ロンドン Method and system for localization microscopy
CN108398774B (en) * 2018-01-18 2021-03-02 中国科学院广州生物医药与健康研究院 Light sheet microscope
WO2019153530A1 (en) * 2018-02-06 2019-08-15 西安电子科技大学 Bimodal raman-optical projection tomography imaging system
CN108469429B (en) 2018-02-06 2020-11-24 西安电子科技大学 Bimodal Raman-optical projection tomography system
US10247910B1 (en) 2018-03-14 2019-04-02 Nanotronics Imaging, Inc. Systems, devices and methods for automatic microscopic focus
US10146041B1 (en) 2018-05-01 2018-12-04 Nanotronics Imaging, Inc. Systems, devices and methods for automatic microscope focus
CN108732124B (en) * 2018-05-21 2023-05-26 深圳市重投华讯太赫兹科技有限公司 Three-dimensional tomography system and method
CN108956562B (en) * 2018-06-11 2020-05-22 浙江大学 Light section fluorescence microscopic imaging method and device based on repositioning
CN108645831B (en) * 2018-06-14 2020-11-20 厦门大学 Multifunctional surface plasma coupled emission fluorescence and Raman detector and detection method thereof
DE102018115001A1 (en) * 2018-06-21 2019-12-24 Carl Zeiss Microscopy Gmbh Procedure for calibrating a phase mask and microscope
EP3620841A1 (en) * 2018-09-07 2020-03-11 ETH Zurich Automated system for wide-field multiphoton microscope
CN109297949B (en) * 2018-09-19 2024-04-05 上海镭立激光科技有限公司 Tumor cell detection method and device by combining microscopic image with transmission Raman spectrum
CN109656028A (en) * 2019-01-11 2019-04-19 中国科学院广州生物医药与健康研究院 A kind of system and method generating diffraction light-free
US11187659B2 (en) * 2019-03-28 2021-11-30 The Regents Of The University Of California Systems for fluorescence light sheet microscopy of large samples in high refractive index solutions
WO2020206420A1 (en) * 2019-04-05 2020-10-08 Cytoveris Inc. Angular depth resolved raman spectroscopy apparatus and method
CN110441983B (en) * 2019-07-24 2022-09-09 成都仲伯科技有限公司 X-ray high-resolution imaging method based on optical transfer function
WO2021178950A1 (en) * 2020-03-06 2021-09-10 Georgia Tech Research Corporation Tomographic imaging systems and methods
CN112821946A (en) * 2021-01-06 2021-05-18 广东工业大学 Short-distance free space optical interconnection system based on self-accelerating light beam
CN113075174B (en) * 2021-03-12 2022-07-05 华中科技大学 Oblique top-mounted static Bessel optical sheet imaging system
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Also Published As

Publication number Publication date
JP6166776B2 (en) 2017-07-19
US10444520B2 (en) 2019-10-15
ES2898616T3 (en) 2022-03-08
JP2015514235A (en) 2015-05-18
CA2869359C (en) 2021-03-23
US20150029325A1 (en) 2015-01-29
WO2013150273A1 (en) 2013-10-10
CA2869359A1 (en) 2013-10-10
CN104204898B (en) 2017-12-15
EP2834695B1 (en) 2021-08-25
EP2834695A1 (en) 2015-02-11
CN104204898A (en) 2014-12-10

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