IN2014DN08394A - - Google Patents
Info
- Publication number
- IN2014DN08394A IN2014DN08394A IN8394DEN2014A IN2014DN08394A IN 2014DN08394 A IN2014DN08394 A IN 2014DN08394A IN 8394DEN2014 A IN8394DEN2014 A IN 8394DEN2014A IN 2014DN08394 A IN2014DN08394 A IN 2014DN08394A
- Authority
- IN
- India
- Prior art keywords
- cell responses
- hiv
- pathogen
- toggle
- cytokines
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6866—Interferon
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
- G01N33/56988—HIV or HTLV
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/525—Tumor necrosis factor [TNF]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/555—Interferons [IFN]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
Abstract
The invention relates to a method and a diagnostic kit for monitoring HIV specific T cell responses and identifying subjects capable of controlling HIV progression or preventing HIV infection altogether. The method is based on the combined use of boosted flow cytometry and toggle peptides and can cover a vastly larger set of effector functions than standard assays. The method is also suitable to detect T cell responses of any desirable cytokine or combination of cytokines to any pathogen.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261615038P | 2012-03-23 | 2012-03-23 | |
EP12382109 | 2012-03-23 | ||
PCT/EP2013/056110 WO2013139972A1 (en) | 2012-03-23 | 2013-03-22 | Method for monitoring hiv specific t cell responses |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014DN08394A true IN2014DN08394A (en) | 2015-05-08 |
Family
ID=49221879
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN8394DEN2014 IN2014DN08394A (en) | 2012-03-23 | 2013-03-22 |
Country Status (9)
Country | Link |
---|---|
US (1) | US9709577B2 (en) |
EP (1) | EP2828656B1 (en) |
JP (1) | JP6272820B2 (en) |
CN (1) | CN104272108A (en) |
CA (1) | CA2868066C (en) |
HK (1) | HK1205264A1 (en) |
IN (1) | IN2014DN08394A (en) |
MX (1) | MX2014011484A (en) |
WO (1) | WO2013139972A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101777252B1 (en) | 2016-07-07 | 2017-09-12 | 대한민국(농림축산식품부 농림축산검역본부장) | Method for evaluating suppression ability of T cell for PRRSV infected-cells |
KR101777256B1 (en) | 2016-07-07 | 2017-09-12 | 대한민국(농림축산식품부 농림축산검역본부장) | Method for evaluating cytotoxic ability of T cell for pathogen infected-cells |
CN110308285B (en) * | 2019-07-12 | 2022-07-26 | 中国人民解放军军事科学院军事医学研究院 | Marker combination for predicting death from severe ionizing radiation injury |
WO2023170189A1 (en) * | 2022-03-09 | 2023-09-14 | Fundacio Privada Institut De Recerca De La Sida-Caixa | Boosted immune monitoring methods for assaying antigen-specific t cell responses |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9624456D0 (en) * | 1996-11-25 | 1997-01-15 | Isis Innovation | Assay method |
US6656471B1 (en) * | 1998-11-17 | 2003-12-02 | Board Of Regents, The University Of Texas System | HIV-specific T-cell induction |
AU2002952548A0 (en) * | 2002-11-08 | 2002-11-21 | Cellestis Limited | Diagnostic assay |
WO2005017192A2 (en) * | 2003-08-14 | 2005-02-24 | The General Hospital Corporation | Screening for gestational disorders |
EP1767937A1 (en) * | 2005-09-27 | 2007-03-28 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method of diagnosis of tuberculosis related immune restoration syndrome (IRS) |
DE602007008209D1 (en) * | 2006-03-20 | 2010-09-16 | St Vincents Hosp Sydney | METHOD FOR DETECTING ANTIGEN-SPECIFIC OR MITOGENIC ACTIVATED T CELLS |
WO2008127840A2 (en) * | 2007-03-22 | 2008-10-23 | University Of Iowa Research Foundation | Flavivirus ns5a proteins for the treatment of hiv |
US20090263828A1 (en) * | 2008-04-16 | 2009-10-22 | Franco Lori | Novel assay for precursor T-cells having high proliferative capacity (PHPC-asay) |
WO2010037408A1 (en) * | 2008-09-30 | 2010-04-08 | Curevac Gmbh | Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof |
JP6401609B2 (en) * | 2011-04-29 | 2018-10-10 | セレクタ バイオサイエンシーズ インコーポレーテッドSelecta Biosciences,Inc. | Tolerogenic synthetic nanocarriers that reduce antibody responses |
-
2013
- 2013-03-22 US US14/386,940 patent/US9709577B2/en active Active
- 2013-03-22 MX MX2014011484A patent/MX2014011484A/en unknown
- 2013-03-22 EP EP13711681.0A patent/EP2828656B1/en active Active
- 2013-03-22 WO PCT/EP2013/056110 patent/WO2013139972A1/en active Application Filing
- 2013-03-22 IN IN8394DEN2014 patent/IN2014DN08394A/en unknown
- 2013-03-22 JP JP2015502244A patent/JP6272820B2/en active Active
- 2013-03-22 CN CN201380022862.8A patent/CN104272108A/en active Pending
- 2013-03-22 CA CA2868066A patent/CA2868066C/en active Active
-
2015
- 2015-06-23 HK HK15105947.6A patent/HK1205264A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP2828656A1 (en) | 2015-01-28 |
US9709577B2 (en) | 2017-07-18 |
WO2013139972A1 (en) | 2013-09-26 |
MX2014011484A (en) | 2015-09-23 |
EP2828656B1 (en) | 2019-09-18 |
JP6272820B2 (en) | 2018-01-31 |
JP2015513100A (en) | 2015-04-30 |
CN104272108A (en) | 2015-01-07 |
US20150057175A1 (en) | 2015-02-26 |
CA2868066C (en) | 2019-11-12 |
CA2868066A1 (en) | 2013-09-26 |
HK1205264A1 (en) | 2015-12-11 |
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