IN2014DN06213A - - Google Patents

Info

Publication number
IN2014DN06213A
IN2014DN06213A IN6213DEN2014A IN2014DN06213A IN 2014DN06213 A IN2014DN06213 A IN 2014DN06213A IN 6213DEN2014 A IN6213DEN2014 A IN 6213DEN2014A IN 2014DN06213 A IN2014DN06213 A IN 2014DN06213A
Authority
IN
India
Prior art keywords
linezolid
isomer
relative
hydroxide
provides
Prior art date
Application number
Inventor
Sujay Biswas
Atulya Kumar Panda
Ashish Kumar Gupta
Shishupal Singh
Praveen Tiwari
Dharam Vir
Saji Thomas
Original Assignee
Jubilant Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jubilant Life Sciences Ltd filed Critical Jubilant Life Sciences Ltd
Priority to IN6213DEN2014 priority Critical patent/IN2014DN06213A/en
Priority claimed from IN267DE2012 external-priority patent/IN2012DE00267A/en
Priority claimed from IN200DE2012 external-priority patent/IN2012DE00200A/en
Publication of IN2014DN06213A publication Critical patent/IN2014DN06213A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention relates to a substantially pure linezolid hydroxide having R isomer content more than about 99.9% relative to its S isomer. Further aspect of invention provides the ambient moisture condition which is critical for enantiomeric pure linezolid hydroxide. The obtained substantially enantiomerically pure linezolid hydroxide compound of formula II can be subsequently converted into the linezolid compound of formula I having S isomer content more than 99.9% relative to R isomer. Further the invention provides an improved process for preparation of enantiomeric pure linezolid Form I wherein linezolid Form I having the purity more than 99.9% relative to any other known polymorphic form of linezolid. The obtained enantiomeric pure linezolid Form I can be subsequently converted into the other known polymorphic forms linezolid. The invention also provides stable and substantially solvent free crystal of Form I of linezolid.
IN6213DEN2014 2012-01-24 2013-01-22 IN2014DN06213A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IN6213DEN2014 IN2014DN06213A (en) 2012-01-24 2013-01-22

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN2254DE2012 2012-07-19
IN267DE2012 IN2012DE00267A (en) 2012-01-31 2013-01-22
PCT/IB2013/050537 WO2013111048A1 (en) 2012-01-24 2013-01-22 Improved process for the preparation of stable crystalline form-i of linezolid, substantially free of residual solvent
IN200DE2012 IN2012DE00200A (en) 2012-01-24 2013-01-22
IN6213DEN2014 IN2014DN06213A (en) 2012-01-24 2013-01-22

Publications (1)

Publication Number Publication Date
IN2014DN06213A true IN2014DN06213A (en) 2015-10-23

Family

ID=47884428

Family Applications (1)

Application Number Title Priority Date Filing Date
IN6213DEN2014 IN2014DN06213A (en) 2012-01-24 2013-01-22

Country Status (4)

Country Link
US (2) US20150025236A1 (en)
EP (1) EP2852580A1 (en)
IN (1) IN2014DN06213A (en)
WO (1) WO2013111048A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108117527A (en) * 2018-01-12 2018-06-05 上海龙翔生物医药开发有限公司 A kind of I preparation method of linezolid form suitable for industrialized production

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688792A (en) 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
CZ200788A3 (en) 1996-04-11 2017-01-25 Pfizer Inc. A method of preparation of 5-aminomethyl substituted oxazolidinone amines
JP2001522828A (en) 1997-11-07 2001-11-20 ファルマシア・アンド・アップジョン・カンパニー Oxazolidinone production
AR027261A1 (en) 2000-02-02 2003-03-19 Upjohn Co LINEZOLID CRYSTAL FORM II
US6444813B2 (en) * 2000-02-02 2002-09-03 Pharmacia & Upjohn Company Linezolid-crystal form II
DK1673370T3 (en) 2003-10-16 2009-12-07 Symed Labs Ltd Crystalline form of linezolid
US7291614B2 (en) 2005-02-24 2007-11-06 Teva Pharmaceutical Industries Ltd. Processes for the preparation of linezolid intermediate
WO2009032294A2 (en) 2007-09-06 2009-03-12 Teva Pharmaceutical Industries Ltd. Processes for the preparation of a linezolid intermediate, linezolid hydroxide
WO2009063505A2 (en) * 2007-10-08 2009-05-22 Usv Limited Process for preparation of (s) (n-[[3-[3-fluoro-4-(4-morpholinyl) hen l -2-oxo-5-oxazolidin l methyl]acetamide
WO2010084514A2 (en) 2009-01-02 2010-07-29 Neuland Laboratories Ltd. A process for the preparation of (5s)-(n)-[[3-[3-fluoro-4-(4-morpholinyl) phenyl]-2-oxo-5-oxazolidinyl] methyl] acetamide
WO2011050826A1 (en) * 2009-10-28 2011-05-05 Synthon B.V. Process for making crystalline form a of linezolid
CA2785620A1 (en) 2009-12-26 2011-06-30 Alembic Pharmaceuticals Limited Process for the preparation of linezolid
WO2011114210A2 (en) 2010-03-15 2011-09-22 Jubilant Life Sciences Limited Processes for the preparation of linezolid
WO2014013498A1 (en) * 2012-07-17 2014-01-23 Symed Labs Limited Amorphous coprecipitates of linezolid

Also Published As

Publication number Publication date
US20170066728A1 (en) 2017-03-09
EP2852580A1 (en) 2015-04-01
WO2013111048A1 (en) 2013-08-01
US20150025236A1 (en) 2015-01-22

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