IN2014DN05786A - - Google Patents

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Publication number
IN2014DN05786A
IN2014DN05786A IN5786DEN2014A IN2014DN05786A IN 2014DN05786 A IN2014DN05786 A IN 2014DN05786A IN 5786DEN2014 A IN5786DEN2014 A IN 5786DEN2014A IN 2014DN05786 A IN2014DN05786 A IN 2014DN05786A
Authority
IN
India
Prior art keywords
maillard reaction
beverage
living body
food
reaction inhibitor
Prior art date
Application number
Inventor
Norihisa Nishida
Akifumi Nagatomo
Hideyuki Ito
Original Assignee
Morishita Jintan Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morishita Jintan Co filed Critical Morishita Jintan Co
Publication of IN2014DN05786A publication Critical patent/IN2014DN05786A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/66—Proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A23L3/3472—Compounds of undetermined constitution obtained from animals or plants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
    • A23L5/27—Removal of unwanted matter, e.g. deodorisation or detoxification by chemical treatment, by adsorption or by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Birds (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)

Abstract

Provided are: a Maillard reaction inhibitor which can inhibit the progress of a Maillard reaction in a living body effectively does not cause any adverse side effect can be applied safely and can be produced without requiring any complicated process; and an anti aging agent for skin an anti diabetic complication agent a food and a beverage in each of which the Maillard reaction inhibitor is used. The Maillard reaction inhibitor according to the present invention contains 50 to 90 mass% of a polyphenol as an active ingredient. The Maillard reaction inhibitor according to the present invention has a potent inhibitory activity on a Maillard reaction and therefore can inhibit a Maillard reaction in a living body efficiently and can prevent and improve various functional disorders of proteins occurring in a living body. Due to this activity the Maillard reaction inhibitor can prevent aging and is useful for the prevention and treatment of diabetic complications. When the tannin is added to a collagen containing food or beverage the occurrence of a Maillard reaction in the food or beverage can be prevented to thereby prevent the deterioration of the food or beverage and the occurrence of a Maillard reaction in a living body can also be prevented.
IN5786DEN2014 2011-12-27 2012-12-27 IN2014DN05786A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011285694 2011-12-27
PCT/JP2012/083992 WO2013100105A1 (en) 2011-12-27 2012-12-27 Maillard reaction inhibitor

Publications (1)

Publication Number Publication Date
IN2014DN05786A true IN2014DN05786A (en) 2015-05-15

Family

ID=48697583

Family Applications (1)

Application Number Title Priority Date Filing Date
IN5786DEN2014 IN2014DN05786A (en) 2011-12-27 2012-12-27

Country Status (14)

Country Link
US (2) US20140349953A1 (en)
EP (1) EP2799075A4 (en)
JP (2) JP5441232B2 (en)
KR (1) KR20140107614A (en)
CN (1) CN104114176A (en)
AU (1) AU2012361496A1 (en)
BR (1) BR112014015928A8 (en)
CA (1) CA2861745A1 (en)
HK (1) HK1199823A1 (en)
IN (1) IN2014DN05786A (en)
PH (1) PH12014501485A1 (en)
RU (1) RU2014131057A (en)
SG (1) SG11201403628SA (en)
WO (1) WO2013100105A1 (en)

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CN104341461B (en) * 2014-10-28 2017-08-29 河南中烟工业有限责任公司 Cigarette monomer perfume Mal Thr, preparation method and applications
CN104341465B (en) * 2014-10-28 2017-08-29 河南中烟工业有限责任公司 Hydrophilic fragrance-enhancing tobacco humectant Mal Ala, preparation method and applications
CN104341464A (en) * 2014-10-28 2015-02-11 河南中烟工业有限责任公司 Hydrophilic tobacco aroma enhancing humectant Mal-Gly as well as preparation method and application thereof
CN104341462B (en) * 2014-10-28 2017-08-29 河南中烟工业有限责任公司 Sugar derivatives cigarette flavouring humectant Mal Trp, preparation method and applications
CN104356174A (en) * 2014-10-28 2015-02-18 河南中烟工业有限责任公司 Monomer spice Mal-Phe for tobacco as well as preparation method and application of monomer spice
CN104341466B (en) * 2014-10-28 2017-08-29 河南中烟工业有限责任公司 Cigarette monomer perfume Mal Val, preparation method and applications
CN104341463B (en) * 2014-10-28 2017-08-29 河南中烟工业有限责任公司 Cigarette monomer perfume Mal Ile, preparation method and applications
CN104341467A (en) * 2014-10-28 2015-02-11 河南中烟工业有限责任公司 Monomer flavor Mal-Amb used for cigarettes as well as preparation method and application thereof
CN104370979A (en) * 2014-10-28 2015-02-25 河南中烟工业有限责任公司 Cigarette monomer spice Mal-Ser as well as preparation method and application thereof
US20170368018A1 (en) * 2014-12-19 2017-12-28 Halo Life Science, Llc Use of ellagic acid dihydrate in pharmaceutical formulations to regulate blood glucose levels
US20170367390A1 (en) * 2014-12-19 2017-12-28 Halo Life Science, Llc Use of ellagic acid dihydrate in food products and nutraceuticals
MX2017010215A (en) * 2015-02-09 2017-11-17 Procter & Gamble Cleaning and/or treatment compositions.
KR101552813B1 (en) * 2015-05-18 2015-09-11 충남대학교산학협력단 Compositions for preventing or treating benign prostatic hyperplasia comprising extracts of Quisqualis indica
JP6586337B2 (en) * 2015-09-29 2019-10-02 株式会社ノエビア Beverage
CN106620746B (en) * 2015-11-02 2019-06-14 中国石油化工股份有限公司 A method of it reducing Maillard reaction and microorganism growth and fermentation inhibitory is acted on
CN106620745B (en) * 2015-11-02 2019-10-11 中国石油化工股份有限公司 A kind of method of Maillard reaction during reduction medium sterilization
JP6673864B2 (en) * 2016-06-30 2020-03-25 林兼産業株式会社 Advanced saccharification product formation inhibitor
WO2018125931A1 (en) 2016-12-30 2018-07-05 Abbott Laboratories Nutritional compositions with protein, beta-hydroxy-beta-methylbutyrate (hmb), and fiber
US12036311B2 (en) 2018-05-30 2024-07-16 Mitsui Sugar Co., Ltd. Anti-obesity agent, anti-dementia agent, deodorant, anti-aging agent, anti-glycation agent, anti-type I allergy agent, hypotensive agent, flavor improving agent, muscle enhancing agent, and bone metabolism improving agent
WO2019230907A1 (en) * 2018-05-30 2019-12-05 三井製糖株式会社 Anti-obesity agent, anti-dementia agent, deodorant, anti-aging agent, anti-glycation agent, anti-type i allergy agent, hypotensive agent, flavor improving agent, muscle enhancing agent, and bone metabolism improving agent
JP7512008B2 (en) * 2018-05-30 2024-07-08 Ｄｍ三井製糖株式会社 Anti-glycation agents
CN109619208A (en) * 2019-02-13 2019-04-16 黑龙江八农垦大学 A kind of imitative meat product and its processing method enhancing flavor
CN111007135B (en) * 2019-12-25 2022-08-02 广东食品药品职业学院 Method for evaluating anti-saccharification effect of plant extract
FR3109301B1 (en) * 2020-04-17 2022-05-06 Soc Ind Limousine Dapplication Biologique ACTIVE INGREDIENT COMPRISING A PARTICULAR PUNICA GRANATUM EXTRACT AND USES FOR PREVENTING AND/OR FIGHTING ACNE
CN114712384B (en) * 2022-04-11 2023-05-16 湖北工业大学 Application of chitosan EGCG composition in inhibiting formation of gastrointestinal cross-linking agent
CN115024357A (en) * 2022-06-20 2022-09-09 东北农业大学 Method for inhibiting generation of advanced glycosylation end products in frozen chicken meatballs
CN115646392A (en) * 2022-11-03 2023-01-31 江西中烟工业有限责任公司 Preparation method and application of Maillard reaction product containing polyphenol

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EP2190445B1 (en) * 2007-07-27 2017-07-19 The State Of Israel-Ministry Of Agriculture & Rural Development Pomegranate sprouts, preparations derived therefrom and compositions comprising same
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JP2013103930A (en) * 2011-11-16 2013-05-30 Koei Kogyo Kk Maillard reaction inhibitor

Also Published As

Publication number Publication date
US20140349953A1 (en) 2014-11-27
WO2013100105A1 (en) 2013-07-04
SG11201403628SA (en) 2014-10-30
JP2014028858A (en) 2014-02-13
US20160058782A1 (en) 2016-03-03
PH12014501485A1 (en) 2014-09-22
JP5441232B2 (en) 2014-03-12
BR112014015928A2 (en) 2017-06-13
CN104114176A (en) 2014-10-22
CA2861745A1 (en) 2013-07-04
JP5538611B2 (en) 2014-07-02
AU2012361496A1 (en) 2014-07-24
JPWO2013100105A1 (en) 2015-05-11
KR20140107614A (en) 2014-09-04
HK1199823A1 (en) 2015-07-24
RU2014131057A (en) 2016-02-20
AU2012361496A2 (en) 2014-07-24
EP2799075A4 (en) 2015-07-15
EP2799075A1 (en) 2014-11-05
BR112014015928A8 (en) 2017-07-04

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