IN2014DN03121A - - Google Patents

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Publication number
IN2014DN03121A
IN2014DN03121A IN3121DEN2014A IN2014DN03121A IN 2014DN03121 A IN2014DN03121 A IN 2014DN03121A IN 3121DEN2014 A IN3121DEN2014 A IN 3121DEN2014A IN 2014DN03121 A IN2014DN03121 A IN 2014DN03121A
Authority
IN
India
Prior art keywords
alkyl
halogen
hydrogen
necessary
further substituted
Prior art date
Application number
Inventor
Marko Mihovilovic
Michael Schnürch
Karlheinz Hilber
Xaver König
Thomas Linder
Agnes Mike
Original Assignee
Tech Universität Wien
Univ Wien Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tech Universität Wien, Univ Wien Med filed Critical Tech Universität Wien
Publication of IN2014DN03121A publication Critical patent/IN2014DN03121A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • C07D251/44—One nitrogen atom with halogen atoms attached to the two other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/50—Two nitrogen atoms with a halogen atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/30—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from cancer cells, e.g. reversion of tumour cells

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to the use of a Compound of the following formula (I), for triggering the differentiation of mammalian cells from cardiomyocyte-like cells, the X being, independently, -NR4- or -0-, R4 being hydrogen or Ci-6-alkyl; Ri being hydroxy, Ci-6-alkyl, Ci-6-alkoxy, carboxy, Ci-6-alkoxycarbonyl, halogen, cyano, nitro, formyl, amino, C-i-6-alkylamino or Di-Ci -6- alkylamino which, if necessary, are further substituted with one or more R5 substituents selected from hydroxy, halogen, cyano and nitro; n equalling 0 to 5; R2 being hydrogen, aryl, lieteroaryl or Ci-6-alkyl, an aryl- or lieteroaryl group being further substituted, if necessary, with one or more R6 substituents, the same options applying for R6 as for Ri, and one Ci-6-alkyl group being further substituted, if necessary, with one or more R5 substituents; R3 being hydrogen, halogen, NR4R7, OR7, SR7 or R7, and the same options applying for R7 as for R2; with the proviso that this Compound of formula (I) is not 3-[(4,6-diphenoxy-l,3,5-triazin-2- yl)amino]benzoic acid.
IN3121DEN2014 2011-09-21 2012-09-21 IN2014DN03121A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ATA1364/2011A AT511441B1 (en) 2011-09-21 2011-09-21 TRIAZINE DERIVATIVES AS DIFFERENTIATOR ACCUMULATORS
PCT/AT2012/050140 WO2013040622A1 (en) 2011-09-21 2012-09-21 Triazine derivatives as differentiation accelerators

Publications (1)

Publication Number Publication Date
IN2014DN03121A true IN2014DN03121A (en) 2015-06-26

Family

ID=47142831

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3121DEN2014 IN2014DN03121A (en) 2011-09-21 2012-09-21

Country Status (5)

Country Link
US (1) US9611457B2 (en)
EP (1) EP2758378A1 (en)
AT (1) AT511441B1 (en)
IN (1) IN2014DN03121A (en)
WO (1) WO2013040622A1 (en)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03008888A (en) * 2001-03-29 2005-03-07 Vertex Pharma Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases.
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
DE102007034679A1 (en) * 2007-07-25 2009-01-29 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Material compositions containing adult stem cells derived from exocrine glandular tissue, especially for use in regenerative medicine, e.g. to restore injured or damaged myocardial tissue
US20120178758A1 (en) * 2009-06-09 2012-07-12 California Capital Equity, Llc Styryl-triazine derivatives and their therapeutical applications
WO2011068879A2 (en) * 2009-12-02 2011-06-09 Research Development Foundation Selection of stem cell clones with defined differentiation capabilities
AT509266B1 (en) 2009-12-28 2014-07-15 Tech Universität Wien SUBSTITUTED PYRIDINES AND PYRIMIDINES
WO2011088031A1 (en) * 2010-01-13 2011-07-21 Glaxosmithkline Llc Compounds and methods

Also Published As

Publication number Publication date
AT511441A4 (en) 2012-12-15
EP2758378A1 (en) 2014-07-30
WO2013040622A1 (en) 2013-03-28
US20140234965A1 (en) 2014-08-21
AT511441B1 (en) 2012-12-15
US9611457B2 (en) 2017-04-04

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IN2014DN03121A (en)