IN2014DN02217A - - Google Patents

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Publication number
IN2014DN02217A
IN2014DN02217A IN2217DEN2014A IN2014DN02217A IN 2014DN02217 A IN2014DN02217 A IN 2014DN02217A IN 2217DEN2014 A IN2217DEN2014 A IN 2217DEN2014A IN 2014DN02217 A IN2014DN02217 A IN 2014DN02217A
Authority
IN
India
Prior art keywords
mof
ibs
dyspepsia
receptor
pharmaceutically
Prior art date
Application number
Inventor
Alterman Mathias
Hallberg Anders
Andappan Mrugaiah
Original Assignee
Vicore Pharma Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vicore Pharma Ab filed Critical Vicore Pharma Ab
Publication of IN2014DN02217A publication Critical patent/IN2014DN02217A/en

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/10—Laxatives
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D333/40—Thiophene-2-carboxylic acid

Abstract

There is provided a compound of formula I ,wherein R1a, R1b, X, Y1, Y2, Y3, Y4, Zl, Z2 R2 and R3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.
IN2217DEN2014 2005-04-12 2006-04-12 IN2014DN02217A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67024905P 2005-04-12 2005-04-12
PCT/GB2006/001334 WO2006109058A1 (en) 2005-04-12 2006-04-12 New bicyclic angiotensin ii agonists

Publications (1)

Publication Number Publication Date
IN2014DN02217A true IN2014DN02217A (en) 2015-07-10

Family

ID=36645608

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2217DEN2014 IN2014DN02217A (en) 2005-04-12 2006-04-12

Country Status (11)

Country Link
US (1) US8357710B2 (en)
EP (1) EP1869009B1 (en)
JP (2) JP5179349B2 (en)
KR (1) KR101488812B1 (en)
CN (1) CN101193881A (en)
AU (1) AU2006235708B2 (en)
CA (1) CA2603254C (en)
ES (1) ES2582945T3 (en)
IN (1) IN2014DN02217A (en)
MX (1) MX2007012633A (en)
WO (1) WO2006109058A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007012633A (en) * 2005-04-12 2008-01-11 Vicore Pharma Ab New bicyclic angiotensin ii agonists.
KR101251933B1 (en) * 2007-06-20 2013-04-09 미쓰비시 타나베 파마 코퍼레이션 Novel malonic acid sulfonamide derivative and pharmaceutical use thereof
EP3127554A4 (en) 2014-04-03 2017-12-06 National Cerebral and Cardiovascular Center Medicine for suppressing malignant tumor metastasis
WO2016107879A2 (en) * 2014-12-30 2016-07-07 Vicore Pharma Ab New use of angiotensin ii receptor agonists
CN107531721B (en) * 2015-04-30 2020-07-17 诺华股份有限公司 Fused tricyclic pyrazole derivatives for modulating farnesoid X receptors
WO2017204163A1 (en) * 2016-05-23 2017-11-30 国立研究開発法人国立循環器病研究センター Drug for preventing or suppressing lung damage

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Also Published As

Publication number Publication date
CA2603254A1 (en) 2006-10-19
AU2006235708B2 (en) 2011-11-10
AU2006235708A1 (en) 2006-10-19
KR101488812B1 (en) 2015-02-02
MX2007012633A (en) 2008-01-11
US8357710B2 (en) 2013-01-22
JP2008535900A (en) 2008-09-04
KR20080011282A (en) 2008-02-01
ES2582945T3 (en) 2016-09-16
CN101193881A (en) 2008-06-04
EP1869009A1 (en) 2007-12-26
WO2006109058A1 (en) 2006-10-19
EP1869009B1 (en) 2016-06-01
JP2013067631A (en) 2013-04-18
CA2603254C (en) 2013-10-29
JP5179349B2 (en) 2013-04-10
US20090069382A1 (en) 2009-03-12

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