IN2014DE00822A - - Google Patents

Info

Publication number

IN2014DE00822A

IN2014DE00822A IN822DE2014A IN2014DE00822A IN 2014DE00822 A IN2014DE00822 A IN 2014DE00822A IN 822DE2014 A IN822DE2014 A IN 822DE2014A IN 2014DE00822 A IN2014DE00822 A IN 2014DE00822A

Authority

IN

India

Prior art keywords

subject

borapetoside

metabolite

prodrug

solvate

Prior art date

2014-03-20

Links

• Espacenet
• Global Dossier
• Discuss

• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
• UQBSOXXWYBLSSJ-UHFFFAOYSA-N Borapetoside F Natural products CC12C(C(=O)OC)=CCCC2C2(C)CC(C3=COC=C3)OC(=O)C2=CC1OC1OC(CO)C(O)C(O)C1O UQBSOXXWYBLSSJ-UHFFFAOYSA-N 0.000 abstract 1
• 102000004877 Insulin Human genes 0.000 abstract 1
• 108090001061 Insulin Proteins 0.000 abstract 1
• RBPCODNTTHTSFN-DOKCBJKLSA-N Tinocrisporide Natural products COC(=O)C1=CCC[C@@H]2[C@]3(C)C[C@@H](OC(=O)[C@@H]3C[C@@H](O[C@H]4O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]4O)[C@@]12C)c5cocc5 RBPCODNTTHTSFN-DOKCBJKLSA-N 0.000 abstract 1
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
• GCXIISSOWSXMCD-WOVZMQRJSA-N borapetoside A Natural products C[C@]12C[C@H](OC(=O)[C@@H]1C[C@@H]3OC(=O)[C@@]4(O)[C@@H](CC[C@H]2[C@]34C)O[C@H]5O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]5O)c6cocc6 GCXIISSOWSXMCD-WOVZMQRJSA-N 0.000 abstract 1
• GCXIISSOWSXMCD-MZYRCUENSA-N borapetoside a Chemical compound O([C@H]1CC[C@H]2[C@]3(C)C[C@H](OC(=O)[C@@H]3C[C@H]3[C@]2([C@@]1(O)C(=O)O3)C)C1=COC=C1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GCXIISSOWSXMCD-MZYRCUENSA-N 0.000 abstract 1
• 229940125396 insulin Drugs 0.000 abstract 1
• 239000002207 metabolite Substances 0.000 abstract 1
• RBPCODNTTHTSFN-ZDMQDBCMSA-N methyl (2s,4ar,6r,6ar,10as,10bs)-2-(furan-3-yl)-6a,10b-dimethyl-4-oxo-6-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,2,4a,5,6,9,10,10a-octahydrobenzo[f]isochromene-7-carboxylate Chemical compound O([C@@H]1C[C@H]2C(=O)O[C@@H](C[C@@]2(C)[C@@H]2CCC=C([C@]12C)C(=O)OC)C1=COC=C1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RBPCODNTTHTSFN-ZDMQDBCMSA-N 0.000 abstract 1
• 239000000203 mixture Substances 0.000 abstract 1
• 229940002612 prodrug Drugs 0.000 abstract 1
• 239000000651 prodrug Substances 0.000 abstract 1
• 150000003839 salts Chemical class 0.000 abstract 1
• 239000012453 solvate Substances 0.000 abstract 1
• 238000002560 therapeutic procedure Methods 0.000 abstract 1