IN2014DE00281A - - Google Patents

Download PDF

Info

Publication number
IN2014DE00281A
IN2014DE00281A IN281DE2014A IN2014DE00281A IN 2014DE00281 A IN2014DE00281 A IN 2014DE00281A IN 281DE2014 A IN281DE2014 A IN 281DE2014A IN 2014DE00281 A IN2014DE00281 A IN 2014DE00281A
Authority
IN
India
Prior art keywords
compounds
pdes
screened
vivo efficacy
better
Prior art date
Application number
Other languages
English (en)
Inventor
Sanghapal Damodhar Sawant
Lakshma Reddy Ginnereddy
Srinivas Mahesuni
Sajad Hussain Syed
Mohd Ishaq Dar
Amit Nargotra
Priya Mahajan
Ram Asrey Vishwakarma
Original Assignee
Council Scient Ind Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Council Scient Ind Res filed Critical Council Scient Ind Res
Priority to EP14824549.1A priority Critical patent/EP3099689B1/en
Priority to IN281DE2014 priority patent/IN2014DE00281A/en
Priority to US15/115,573 priority patent/US10017511B2/en
Priority to PCT/IN2014/000662 priority patent/WO2015114647A1/en
Publication of IN2014DE00281A publication Critical patent/IN2014DE00281A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IN281DE2014 2014-01-30 2014-10-20 IN2014DE00281A (enExample)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP14824549.1A EP3099689B1 (en) 2014-01-30 2014-10-20 Pyrazolopyrimidinones for the treatment of impotence and process for the preparation thereof
IN281DE2014 IN2014DE00281A (enExample) 2014-01-30 2014-10-20
US15/115,573 US10017511B2 (en) 2014-01-30 2014-10-20 Pyrazolopyrimidinones for the treatment of impotence and process for the preparation thereof
PCT/IN2014/000662 WO2015114647A1 (en) 2014-01-30 2014-10-20 Pyrazolopyrimidinones for the treatment of impotence and process for the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN281DE2014 IN2014DE00281A (enExample) 2014-01-30 2014-10-20

Publications (1)

Publication Number Publication Date
IN2014DE00281A true IN2014DE00281A (enExample) 2015-08-07

Family

ID=52292987

Family Applications (1)

Application Number Title Priority Date Filing Date
IN281DE2014 IN2014DE00281A (enExample) 2014-01-30 2014-10-20

Country Status (4)

Country Link
US (1) US10017511B2 (enExample)
EP (1) EP3099689B1 (enExample)
IN (1) IN2014DE00281A (enExample)
WO (1) WO2015114647A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108558890A (zh) * 2018-06-28 2018-09-21 重庆康刻尔制药有限公司 一种西地那非中间体合成方法
CN111005033B (zh) * 2019-12-16 2020-10-16 浙江大学 一种西地那非中间体的电还原制备方法
CN114369064B (zh) * 2022-01-10 2023-12-19 北京莱瑞森医药科技有限公司 一种西地那非中间体的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
BR9909808A (pt) * 1998-04-20 2000-12-26 Pfizer Pirazolopirimidinonas inibidoras de cgmp pde5 para o tratamento da disfunção sexual
CA2235642C (en) * 1998-05-15 2007-11-13 Torcan Chemical Ltd. Processes for preparing sildenafil
AU2004201386B2 (en) * 1998-09-04 2008-08-28 Ortho-Mcneil Pharmaceutical, Inc. 5-heterocyclyl pyrazolo[4,3-d]pyrimidin-7-ones for the treatment of male erectile dysfunction
AU5925500A (en) * 1999-07-09 2001-01-30 Picower Institute For Medical Research, The Pyrazolopyrimidinone derivatives conjugated to thiophene moieties or benzo [fused] 5-membered heterocycles for erectile dysfunction
IL130968A (en) * 1999-07-15 2002-12-01 Shmuel Simon Pharmaceutical composition comprising sildenafil or its analogs, useful for the treatment of tinnitus and hearing loss
AU2000254308A1 (en) 2000-05-17 2001-11-26 Sk Chemicals Co., Ltd. Pyrazolopyrimidinone derivatives, process for their preparation and their use
EP1630164A1 (en) * 2004-08-31 2006-03-01 Expotrend Company SA Pyrazolopyrimidinones as phosphodiesterase inhibitors
CN101891747B (zh) * 2010-07-02 2012-04-25 张南 抑制5型磷酸二酯酶的化合物及制备方法

Also Published As

Publication number Publication date
EP3099689A1 (en) 2016-12-07
US20170066771A1 (en) 2017-03-09
WO2015114647A1 (en) 2015-08-06
US10017511B2 (en) 2018-07-10
EP3099689B1 (en) 2022-01-26

Similar Documents

Publication Publication Date Title
TW201613925A (en) Imidazopyrazines as LSD1 inhibitors
SMT201900266T1 (it) Composti di pirazolo[1,5-a]piramidin-5,7-diammina come inibitori di cdk e loro uso terapeutico
PH12018500944B1 (en) [1,2,4]TRIAZOLO[1,5-a]PYRIMIDIN-7-YL COMPOUND
IL283149A (en) Inhibitors of HPK1 and their use in the treatment of cancer
ZA202000561B (en) Pyrazolo and triazolo bicyclic compounds as jak kinase inhibitors
MX2019001125A (es) Inhibidores de cinasa macrociclica.
IL266305B (en) History of [4,2,1]triazolo[5,1-a]pyrimidine as pde2 inhibitors
EP3268000A4 (en) Pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives as cdk inhibitors
EA201790259A1 (ru) СОСТАВ ТАБЛЕТОК 2-ФТОР-N-МЕТИЛ-4-[7-(ХИНОЛИН-6-ИЛМЕТИЛ)ИМИДАЗО[1,2-b][1,2,4]ТРИАЗИН-2-ИЛ]БЕНЗАМИДА
TN2017000507A1 (en) Pde9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases
PH12018502168A1 (en) 1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4h-pyrazolo[4,3-c]pyridin-4-ones as pde1 inhibitors
LT3377495T (lt) 2-fenil-3,4-dihidropirolo[2,1-f] [1,2,4]triazinono dariniai kaip fosfodiesterazės inhibitoriai ir jų naudojimas
MX390505B (es) Compuestos de [1,2,4]triazolo[1,5-a]pirimidina como inhibidores de pde2
MX2020009966A (es) Formas de dosificacion y usos terapeuticos de la l-4-cloro quinurenina.
MX386174B (es) Compuestos de [1,2,4]triazolo[1,5-a]pirimidina como inhibidores de pde2
IN2014DE00281A (enExample)
PL3277687T3 (pl) Pochodne 7-(morfolin-4-ylo)pirazolo[1,5-a]pirymidyny użyteczne do leczenia chorób immunologicznych lub zapalnych lub nowotworów
MX369840B (es) Nuevos compuestos derivados de 6, 7-dihidro-3h-oxazolo [3, 4-a] pirazina-5, 8-diona.
IL253427A0 (en) The result of pyrazolo[3,4-d]pyrimidine and its use in the treatment of Jericho rose
EA201990939A1 (ru) ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРИДИНОВЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ RET КИНАЗЫ
HK1238643A1 (en) Pyrazolo[3,4-d]pyrimidin derivative and its use for the treatment of leishmaniasis