IN2014DE00237A - - Google Patents

Abstract

The present invention provides novel AKT inhibitor compounds of formula I wherein a=l or 2 X and Y is each independently selected from C, 0 or N. X and R2 may be directly attached or attached via a linking group L which may be selected from an Oxygen atom or a CO group Z is H or Alkyl R1 = H or F wherein n=0 to 2 R3= aryl optionally substituted by a halogen or an alkylene group; & is a group selected from hydrogen, amine, substituted amine or an amino alkyl group; R2 is wherein A, B, C, D and E are independently selected from H, -CH2, a heteroatom such as C, 0 , N or S; n is 1 to 2; with the proviso that: A, B, C, D, E forms a 5 or 6 membered aromatic ring and at least one of A, B, C, D, E is Nitrogen; AB C D E is optionally substituted by one or more groups selected from amino, N-alkyl amino 0x0, alkoxy, hydroxyl or hydroxy alkyl group; G and F are independently selected from the group comprising hydrogen, amino, alkoxy, hydroxyl-alkyl or an acetamide group or G and F may be fused to form a 5 membered ring 'J'; wherein the Ring J represents pyrrole ring or imidazole ring optionally substituted by one or more substituents independently selected from H, alkyl, hydroxyalkyl or halogen. wherein the valency of fused heterocyclic ring is satisfied by corresponding double bonds as and where applicable.