IN2014CN03364A - - Google Patents

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Publication number
IN2014CN03364A
IN2014CN03364A IN3364CHN2014A IN2014CN03364A IN 2014CN03364 A IN2014CN03364 A IN 2014CN03364A IN 3364CHN2014 A IN3364CHN2014 A IN 3364CHN2014A IN 2014CN03364 A IN2014CN03364 A IN 2014CN03364A
Authority
IN
India
Prior art keywords
nanoparticles
cell epitopes
oligomerization domains
peptide
norovirus
Prior art date
Application number
Inventor
Peter Burkhard
Caroline Kulangara
Original Assignee
Alpha O Peptides Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpha O Peptides Ag filed Critical Alpha O Peptides Ag
Publication of IN2014CN03364A publication Critical patent/IN2014CN03364A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Self assembling peptide nanoparticles (SAPN) incorporating T cell epitopes and displaying the P domain of the norovirus protein VP1 are described. The nanoparticles of the invention consist of aggregates of a continuous peptide chain comprising two coiled coil oligomerization domains connected by a linker segment wherein one or both oligomerization domains incorporate T cell epitopes within their peptide sequence. These nanoparticles are useful as vaccines and adjuvants for the prevention and treatment of norovirus infections.
IN3364CHN2014 2011-10-12 2012-10-05 IN2014CN03364A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11184906 2011-10-12
PCT/EP2012/069684 WO2013053642A1 (en) 2011-10-12 2012-10-05 Self-assembling peptide nanoparticles as vaccines against infection with norovirus

Publications (1)

Publication Number Publication Date
IN2014CN03364A true IN2014CN03364A (en) 2015-09-04

Family

ID=47010584

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3364CHN2014 IN2014CN03364A (en) 2011-10-12 2012-10-05

Country Status (9)

Country Link
US (1) US20140242104A1 (en)
EP (1) EP2766386A1 (en)
JP (1) JP2014530224A (en)
CN (1) CN104136454A (en)
AU (1) AU2012323189A1 (en)
CA (1) CA2851917A1 (en)
IN (1) IN2014CN03364A (en)
RU (1) RU2014106936A (en)
WO (1) WO2013053642A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106021974B (en) * 2016-05-19 2019-05-03 中牧智合（北京）生物技术有限公司 The composition of the method and the peptide library thus prepared that optimized to t cell epitope
EA201991918A1 (en) * 2017-03-23 2020-05-15 Альфа-О Пептидс Аг SELF-ASSEMBLY PROTEIN NANOPARTICLES WITH INTEGRATED PROTEINS WITH A HEXIRAL BEAM
AU2019285048B2 (en) * 2018-06-13 2023-06-08 The Scripps Research Institute Nanoparticle vaccines with novel structural components
WO2020220846A1 (en) * 2019-04-29 2020-11-05 中国人民解放军军事科学院军事医学研究院 Fusion protein capable of self-assembling into protein nanoparticles and application thereof
WO2022106860A1 (en) * 2020-11-20 2022-05-27 Pécsi Tudományegyetem Recombinant peptides for use in therapy
US20240316181A1 (en) * 2021-01-07 2024-09-26 Tokyo Institute Of Technology Conjugated protein monomer carrying peptide derived from pathogenic microorganism compatible with mhc molecule, aggregate of said monomers, component vaccine containing said aggregate as active ingredient, and method for acquiring information on secretion of physiologically active substance after immunization
CN113354716B (en) * 2021-08-11 2021-11-02 北京溯本源和生物科技有限公司 Mouse norovirus recombinant antigen, monoclonal antibody and virus detection test strip

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2581394B1 (en) 1985-05-02 1988-08-05 Grp Genie Genetique PARTICLES HAVING IMMUNOGENIC PROPERTIES OF THE HBS ANTIGEN AND CARRYING A FOREIGN ANTIGENIC SITE TO THE EPITOPES CARRIED BY THE HBS ANTIGEN, ANIMAL VECTORS AND CELLS FOR THE PRODUCTION OF SUCH PARTICLES AND COMPOSITIONS CONTAINING SUCH PARTICLES FOR THE PRODUCTION
JP3926839B2 (en) 1993-09-14 2007-06-06 エピミューン，インコーポレイティド Modification of immune response using universal DR-binding peptides
JP4085231B2 (en) 2000-02-28 2008-05-14 株式会社ビークル Protein hollow nanoparticles, substance carrier using the same, and method for introducing substance into cells
US8575110B2 (en) 2003-02-17 2013-11-05 Alpha-O Peptides G Peptidic nanoparticles as drug delivery and antigen display systems
AU2008302276B2 (en) * 2006-09-29 2013-10-10 Takeda Vaccines, Inc. Method of conferring a protective immune response to norovirus
RU2540871C2 (en) * 2008-02-01 2015-02-10 Альфа-О Пептидес Аг Self-assembling peptide nanoparticles effective as vaccines
DE602008004898D1 (en) * 2008-06-27 2011-03-24 Theranor Sprl Pharmaceutical compositions of antibodies to viral diseases

Also Published As

Publication number Publication date
AU2012323189A1 (en) 2014-03-06
EP2766386A1 (en) 2014-08-20
RU2014106936A (en) 2015-11-20
US20140242104A1 (en) 2014-08-28
CN104136454A (en) 2014-11-05
JP2014530224A (en) 2014-11-17
WO2013053642A1 (en) 2013-04-18
CA2851917A1 (en) 2013-04-18

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