IN2014CN02807A - - Google Patents

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Publication number
IN2014CN02807A
IN2014CN02807A IN2807CHN2014A IN2014CN02807A IN 2014CN02807 A IN2014CN02807 A IN 2014CN02807A IN 2807CHN2014 A IN2807CHN2014 A IN 2807CHN2014A IN 2014CN02807 A IN2014CN02807 A IN 2014CN02807A
Authority
IN
India
Prior art keywords
hcv
compound
rsndathe
tetrahydrocyclopropa
indolo
Prior art date
Application number
Inventor
Zhizhen Barbara Zheng
Stanley Dandrea
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IN2014CN02807A publication Critical patent/IN2014CN02807A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

RSNdaThe present invention provides (1a 12b) 8 cyclohexyl 11 fluoro ((1 methylcyclopropyl)sulfonyl) 1a ((3 methyl 3 8 diazabicyclo[3.2.1]oct 8 yl)carbonyl) 1 1a 2 12b tetrahydrocyclopropa[]indolo[2 1 ][2]benzazepine 5 carboxamide (formula I) including pharmaceutically acceptable salts as well as compositions and methods of using the compound. The compound has activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
IN2807CHN2014 2011-10-20 2012-10-17 IN2014CN02807A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161549450P 2011-10-20 2011-10-20
PCT/US2012/060537 WO2013059265A1 (en) 2011-10-20 2012-10-17 A compound for the treatment of hepatitis c

Publications (1)

Publication Number Publication Date
IN2014CN02807A true IN2014CN02807A (en) 2015-07-03

Family

ID=47144132

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2807CHN2014 IN2014CN02807A (en) 2011-10-20 2012-10-17

Country Status (10)

Country Link
US (1) US8716275B2 (en)
EP (1) EP2768831B1 (en)
JP (1) JP2014530860A (en)
CN (1) CN104203949B (en)
AR (1) AR088470A1 (en)
ES (1) ES2559295T3 (en)
IN (1) IN2014CN02807A (en)
TW (1) TW201323426A (en)
UY (1) UY34400A (en)
WO (1) WO2013059265A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2792360A1 (en) 2013-04-18 2014-10-22 IP Gesellschaft für Management mbH (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide for use in treating HCV
AU2014296106B2 (en) 2013-07-31 2020-02-27 Hb Innovations, Inc. Infant calming/sleep-aid, SIDS prevention device, and method of use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7348425B2 (en) * 2004-08-09 2008-03-25 Bristol-Myers Squibb Company Inhibitors of HCV replication
US7399758B2 (en) * 2005-09-12 2008-07-15 Meanwell Nicholas A Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
WO2007092000A1 (en) * 2006-02-06 2007-08-16 Bristol-Myers Squibb Company Inhibitors of hcv replication
CN101443336B (en) * 2006-05-17 2012-07-04 百时美施贵宝公司 Cyclopropyl fused indolobenzazepine HVC ns5b inhibitors
US7456166B2 (en) * 2006-05-17 2008-11-25 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
US7547690B2 (en) * 2007-03-14 2009-06-16 Bristol-Myers Squibb Company Compounds for the treatment of Hepatitis C
US8129367B2 (en) * 2007-11-21 2012-03-06 Bristol-Myers Squibb Company Compounds for the treatment of Hepatitis C
TWI454476B (en) * 2008-07-08 2014-10-01 Tibotec Pharm Ltd Macrocyclic indole derivatives useful as hepatitis c virus inhibitors

Also Published As

Publication number Publication date
AR088470A1 (en) 2014-06-11
WO2013059265A1 (en) 2013-04-25
EP2768831A1 (en) 2014-08-27
CN104203949B (en) 2016-06-22
EP2768831B1 (en) 2015-11-25
JP2014530860A (en) 2014-11-20
TW201323426A (en) 2013-06-16
ES2559295T3 (en) 2016-02-11
UY34400A (en) 2013-05-31
US20130102589A1 (en) 2013-04-25
CN104203949A (en) 2014-12-10
US8716275B2 (en) 2014-05-06

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