IN2013MU03017AIN3017MU2013AIN2013MU03017AIN 2013MU03017 AIN2013MU03017 AIN 2013MU03017AIN 3017MU2013 AIN3017MU2013 AIN 3017MU2013AIN 2013MU03017 AIN2013MU03017 AIN 2013MU03017A
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IN
India
Prior art keywords
vildagliptin
formula
pure
compound
preparation
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Application number
Inventor
Shri Prakash Dhar Dwivedi
Kumar Kamlesh Singh
Nitin Tandon
Shankar Dada Jadhav
Tirth Harkrishna Thaker
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Cadila Helathcare Ltd
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Application filed by Cadila Helathcare LtdfiledCriticalCadila Helathcare Ltd
Priority to IN3017MU2013priorityCriticalpatent/IN2013MU03017A/en
Publication of IN2013MU03017ApublicationCriticalpatent/IN2013MU03017A/en
AN IMPROVED PROCESS FOR PREPARATION OF VILDAGLIPTIN ABSTRACT The present invention relates to a process for the preparation of pure vildagliptin of Formula and a pharmaceutical composition comprising pure vildagliptin. The process comprises reacting L-prolinamide with haloacetyl chloride in one or more of organic solvents and in the presence of base, condensing the compound so obtained with 1-amino-adamantane-3-ol in the presence of a base; dehydrating the compound so obtained with dehydrating agent to obtain vildagliptin of Formula I; and optionally, purifying the vildagliptin to obtain pure vildagliptin of Formula.
New thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them compounds of formula (i): wherein r1, r2, r3, r4, r5, r6, r7, r12, x, a and n are as defined in the description.