IN2013MU02001A - - Google Patents

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Publication number
IN2013MU02001A
IN2013MU02001A IN2001MU2013A IN2013MU02001A IN 2013MU02001 A IN2013MU02001 A IN 2013MU02001A IN 2001MU2013 A IN2001MU2013 A IN 2001MU2013A IN 2013MU02001 A IN2013MU02001 A IN 2013MU02001A
Authority
IN
India
Prior art keywords
formula
solid obtained
compound
vilazodone
solution
Prior art date
Application number
Inventor
Nitin Vilas Patil
Mahesh Ganpatrao Deshpande
Sachin Arun Sasane
Dnyaneshwar Bapurao Thakare
Rajesh Vyas
Nandu Baban Bhise
Girij Pal Singh
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Priority to PCT/IB2014/062132 priority Critical patent/WO2014199313A1/en
Priority to IN2001MU2013 priority patent/IN2013MU02001A/en
Publication of IN2013MU02001A publication Critical patent/IN2013MU02001A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a process for preparation of substantially pure Vilazodone Hydrochloride and also relates to an isolated impurity of Vilazodone. The said process for producing Vilazodone, 1-[4-(5-cyanoindol-3-yl) butyl]-4-(2-carbonyl benzofuran-5-yl) piperazine represented by formula (1) or a pharmaceutically acceptable salt thereof comprises condensing the compound of formula (2) With a compound of formula (3) in an alcoholic solvent to obtain a white to yellow solid; isolating the solid obtained therefrom; slurry washing the solid obtained with water miscible solvent; dissolving the solid obtained therefrom in an amide solvent to obtain a solution; adding an aqueous solution of sodium metabisulphite and an inorganic base to the solution obtained to obtain the compound of formula (1) and optionally converting the solid obtained in step (v) to its pharmaceutically acceptable salt.
IN2001MU2013 2013-06-12 2014-06-11 IN2013MU02001A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/IB2014/062132 WO2014199313A1 (en) 2013-06-12 2014-06-11 Substantially pure vilazodone hydrochloride and a process thereof
IN2001MU2013 IN2013MU02001A (en) 2013-06-12 2014-06-11

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN2001MU2013 IN2013MU02001A (en) 2013-06-12 2014-06-11

Publications (1)

Publication Number Publication Date
IN2013MU02001A true IN2013MU02001A (en) 2015-05-29

Family

ID=51355568

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2001MU2013 IN2013MU02001A (en) 2013-06-12 2014-06-11

Country Status (2)

Country Link
IN (1) IN2013MU02001A (en)
WO (1) WO2014199313A1 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4333254A1 (en) 1993-09-30 1995-04-06 Merck Patent Gmbh Piperidines and piperazines
DE19514567A1 (en) 1995-04-20 1996-10-24 Merck Patent Gmbh Benzofurans
UA76758C2 (en) 2001-06-19 2006-09-15 Мерк Патент Гмбх Polymorph forms of hydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine
DE102005019670A1 (en) 2005-04-26 2006-11-02 Merck Patent Gmbh Preparation of 5-(4-(4-(5-cyano-3-indolyl)-butyl)-1-piperazinyl)-benzofuran-2-carboxamide, comprises reacting a heterocyclic compound with a carbonitrile compound; and/or converting the obtained benzofuran compound to its salt
WO2014061000A1 (en) * 2012-10-19 2014-04-24 Ranbaxy Laboratories Limited Process for the preparation of vilazodone or pharmaceutically acceptable salt thereof

Also Published As

Publication number Publication date
WO2014199313A1 (en) 2014-12-18

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