IN2013MU02001A - - Google Patents
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- Publication number
- IN2013MU02001A IN2013MU02001A IN2001MU2013A IN2013MU02001A IN 2013MU02001 A IN2013MU02001 A IN 2013MU02001A IN 2001MU2013 A IN2001MU2013 A IN 2001MU2013A IN 2013MU02001 A IN2013MU02001 A IN 2013MU02001A
- Authority
- IN
- India
- Prior art keywords
- formula
- solid obtained
- compound
- vilazodone
- solution
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
The present invention relates to a process for preparation of substantially pure Vilazodone Hydrochloride and also relates to an isolated impurity of Vilazodone. The said process for producing Vilazodone, 1-[4-(5-cyanoindol-3-yl) butyl]-4-(2-carbonyl benzofuran-5-yl) piperazine represented by formula (1) or a pharmaceutically acceptable salt thereof comprises condensing the compound of formula (2) With a compound of formula (3) in an alcoholic solvent to obtain a white to yellow solid; isolating the solid obtained therefrom; slurry washing the solid obtained with water miscible solvent; dissolving the solid obtained therefrom in an amide solvent to obtain a solution; adding an aqueous solution of sodium metabisulphite and an inorganic base to the solution obtained to obtain the compound of formula (1) and optionally converting the solid obtained in step (v) to its pharmaceutically acceptable salt.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2001MU2013 IN2013MU02001A (en) | 2013-06-12 | 2014-06-11 | |
PCT/IB2014/062132 WO2014199313A1 (en) | 2013-06-12 | 2014-06-11 | Substantially pure vilazodone hydrochloride and a process thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2001MU2013 IN2013MU02001A (en) | 2013-06-12 | 2014-06-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2013MU02001A true IN2013MU02001A (en) | 2015-05-29 |
Family
ID=51355568
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN2001MU2013 IN2013MU02001A (en) | 2013-06-12 | 2014-06-11 |
Country Status (2)
Country | Link |
---|---|
IN (1) | IN2013MU02001A (en) |
WO (1) | WO2014199313A1 (en) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4333254A1 (en) | 1993-09-30 | 1995-04-06 | Merck Patent Gmbh | Piperidines and piperazines |
DE19514567A1 (en) | 1995-04-20 | 1996-10-24 | Merck Patent Gmbh | Benzofurans |
UA76758C2 (en) | 2001-06-19 | 2006-09-15 | Мерк Патент Гмбх | Polymorph forms of hydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine |
DE102005019670A1 (en) | 2005-04-26 | 2006-11-02 | Merck Patent Gmbh | Preparation of 5-(4-(4-(5-cyano-3-indolyl)-butyl)-1-piperazinyl)-benzofuran-2-carboxamide, comprises reacting a heterocyclic compound with a carbonitrile compound; and/or converting the obtained benzofuran compound to its salt |
WO2014061000A1 (en) * | 2012-10-19 | 2014-04-24 | Ranbaxy Laboratories Limited | Process for the preparation of vilazodone or pharmaceutically acceptable salt thereof |
-
2014
- 2014-06-11 IN IN2001MU2013 patent/IN2013MU02001A/en unknown
- 2014-06-11 WO PCT/IB2014/062132 patent/WO2014199313A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2014199313A1 (en) | 2014-12-18 |
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IN2013MU02001A (en) |