IN2013MU01466A - - Google Patents

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Publication number
IN2013MU01466A
IN2013MU01466A IN1466MU2013A IN2013MU01466A IN 2013MU01466 A IN2013MU01466 A IN 2013MU01466A IN 1466MU2013 A IN1466MU2013 A IN 1466MU2013A IN 2013MU01466 A IN2013MU01466 A IN 2013MU01466A
Authority
IN
India
Prior art keywords
clomipramine
formula
sulfate
hydrochloride
water
Prior art date
Application number
Inventor
Vitthal Genbhau Gund
Santosh Shivaji Shingote
Rahul Babanrao Shinde
Prasad Ramakant Kulkarni
Original Assignee
Herbert Brown Pharmaceutical & Res Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Herbert Brown Pharmaceutical & Res Lab filed Critical Herbert Brown Pharmaceutical & Res Lab
Priority to IN1466MU2013 priority Critical patent/IN2013MU01466A/en
Publication of IN2013MU01466A publication Critical patent/IN2013MU01466A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to an improved process for the preparation of Clomipramine salts, particularly Clomipramine hydrochloride of Formula I and Clomipramine sulfate of Formula II. The process for the preparation of Clomipramine hydrochloride of Formula I comprises of reacting 3-chloroiminodibenzyl with N,N-dimethylaminopropyl chloride in an aromatic hydrocarbon in presence of an alkali metal hydroxide; filtering the reaction mixture, cooling, diluting with water and adding aqueous sulfuric acid to obtain crude Clomipramine sulfate; recrystallizing the crude Clomipramine sulfate using acetone-water mixture to obtain Clomipramine sulfate of Formula II having HPLC purity of more than 99.5%; suspending Clomipramine sulfate of Formula II in water, adding an aqueous alkali metal hydroxide solution and an aliphatic hydrocarbon, stirring and separating an aqueous layer and an organic layer; charcoalizing the organic layer, cooling and adjusting pH by addition of alcoholic hydrochloride to yield Clomipramine hydrochloride of Formula I having HPLC purity of more than 99.7%.
IN1466MU2013 2013-04-22 2013-04-22 IN2013MU01466A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IN1466MU2013 IN2013MU01466A (en) 2013-04-22 2013-04-22

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN1466MU2013 IN2013MU01466A (en) 2013-04-22 2013-04-22

Publications (1)

Publication Number Publication Date
IN2013MU01466A true IN2013MU01466A (en) 2015-04-17

Family

ID=54394648

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1466MU2013 IN2013MU01466A (en) 2013-04-22 2013-04-22

Country Status (1)

Country Link
IN (1) IN2013MU01466A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108409660A (en) * 2018-05-14 2018-08-17 刘可 A kind of preparation method of antidepressant agents impurity isomers
CN108409659A (en) * 2018-05-14 2018-08-17 刘可 A kind of preparation method of antidepressant agents impurity isomers key intermediate
CN108707112A (en) * 2018-05-14 2018-10-26 刘可 A kind of preparation method of antidepressant agents impurity isomers chlorine nitre phenyl intermediates

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108409660A (en) * 2018-05-14 2018-08-17 刘可 A kind of preparation method of antidepressant agents impurity isomers
CN108409659A (en) * 2018-05-14 2018-08-17 刘可 A kind of preparation method of antidepressant agents impurity isomers key intermediate
CN108707112A (en) * 2018-05-14 2018-10-26 刘可 A kind of preparation method of antidepressant agents impurity isomers chlorine nitre phenyl intermediates

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