IN2013MU01180AIN1180MU2013AIN2013MU01180AIN 2013MU01180 AIN2013MU01180 AIN 2013MU01180AIN 1180MU2013 AIN1180MU2013 AIN 1180MU2013AIN 2013MU01180 AIN2013MU01180 AIN 2013MU01180A
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India
Prior art keywords
compound
formula
solid form
solution
morphoiin
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Inventor
Prashant Ladkat
Ashutosh Jagtap
Mita Roy
Sivaramakrishnan Hariharan
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Piramal Entpr Ltd
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Priority to IN1180MU2013priorityCriticalpatent/IN2013MU01180A/en
Publication of IN2013MU01180ApublicationCriticalpatent/IN2013MU01180A/en
The present invention relates to an improved process for producing dibenzyl{3-[2(R)-[(lR)-l-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morphoIin-4-yl]-5-oxo-4,5-dihydro-[l,2,4]-triazol-l-yl]phosphonic acid (the compound of formula I) in a solid form, comprising dissolving the compound of formula I in an oily form in an organic solvent or a mixture thereof at a temperature of 35-50°C to obtain a solution and crystallising out the compound of formula I in solid form by cooling the obtained solution at 0-10°C.
Process for preparing 2,3-diaminopropionic acid derivatives; the intermediary compounds considered; and the procedures for preparing intermediate compounds.
A novel process for the preparation of n-(4-nitro-2-sulfamoyl-phe nyl)-malonamic acid methyl ester and n-(4-amino-2-sulfamoyl-pheny l)-malonamic acid methyl ester.