IN2013MU01159AIN1159MU2013AIN2013MU01159AIN 2013MU01159 AIN2013MU01159 AIN 2013MU01159AIN 1159MU2013 AIN1159MU2013 AIN 1159MU2013AIN 2013MU01159 AIN2013MU01159 AIN 2013MU01159A
Authority
IN
India
Prior art keywords
metformin
salts
compositions
sitagliptin
present
Prior art date
Application number
Inventor
Girish Kumar Jain
Venkataramana Naidu
Atul Patil
Original Assignee
Wockhardt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt LtdfiledCriticalWockhardt Ltd
Priority to PCT/IB2014/060029priorityCriticalpatent/WO2014167437A1/en
Priority to US14/766,753prioritypatent/US20150374688A1/en
Priority to IN1159MU2013prioritypatent/IN2013MU01159A/en
Priority to EP14721970.3Aprioritypatent/EP3033075A1/en
Publication of IN2013MU01159ApublicationCriticalpatent/IN2013MU01159A/en
The present invention provides solid oral pharmaceutical compositions comprising combination of metformin and sitagliptin or salts thereof. In particular, the present invention relates to a multilayered coated pharmaceutical composition comprising at least two compartments of metformin or salts thereof exhibiting immediate and extended release and at least one compartment of sitagliptin and metformin or salts thereof exhibiting immediate release. The invention also includes process of preparing such compositions and method of use of such compositions for treating type II diabetes.
Compounds derived from substituted benzylindazoles, bub1 kinase inhibitors; manufacturing procedure; pharmaceutical composition; pharmaceutical combination; and its use in the treatment of hyperproliferative diseases.
Compounds derived from pyrazole sglt1 inhibitors; method to treat diabetes; pharmaceutical composition; use of the compound for the treatment of type 1 and type 2 diabetes.