IN2013MN02414A - - Google Patents

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Publication number
IN2013MN02414A
IN2013MN02414A IN2414MUN2013A IN2013MN02414A IN 2013MN02414 A IN2013MN02414 A IN 2013MN02414A IN 2414MUN2013 A IN2414MUN2013 A IN 2414MUN2013A IN 2013MN02414 A IN2013MN02414 A IN 2013MN02414A
Authority
IN
India
Prior art keywords
benzothiazinethione
derivatives
formula
significant effect
mycobacterium tuberculosis
Prior art date
Application number
Inventor
Luoting Yu
Yuquan Wei
Original Assignee
Univ Sichuan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Sichuan filed Critical Univ Sichuan
Publication of IN2013MN02414A publication Critical patent/IN2013MN02414A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

Benzothiazinethione derivatives of formula (I) their preparative methods and uses are provided. Benzothiazinethione derivatives of the invention have significant effect of inhibiting Mycobacterium tuberculosis.
IN2414MUN2013 2011-05-27 2011-06-15 IN2013MN02414A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201110139840.2A CN102276598B (en) 2011-05-27 2011-05-27 Benzothiazine-thione derivatives, preparation method thereof and purpose thereof
PCT/CN2011/075750 WO2012162912A1 (en) 2011-05-27 2011-06-15 Benzothiazinethione derivatives and their preparative methods and uses

Publications (1)

Publication Number Publication Date
IN2013MN02414A true IN2013MN02414A (en) 2015-06-12

Family

ID=45102383

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2414MUN2013 IN2013MN02414A (en) 2011-05-27 2011-06-15

Country Status (6)

Country Link
US (1) US20140303152A1 (en)
EP (1) EP2719691A1 (en)
CN (1) CN102276598B (en)
IN (1) IN2013MN02414A (en)
RU (1) RU2013157860A (en)
WO (1) WO2012162912A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103508980B (en) * 2012-06-14 2016-07-06 四川大学 Benzothiazine-4-ketone derivatives and its production and use
US9572809B2 (en) 2012-07-18 2017-02-21 Spero Trinem, Inc. Combination therapy to treat Mycobacterium diseases
CN104211708B (en) * 2013-05-29 2018-08-24 中国医学科学院药物研究所 Benzoxazinone derivatives and its application as antiseptic
US9481683B2 (en) * 2014-06-09 2016-11-01 University Of Notre Dame Du Lac 1,3-benzothiazinone sulfoxide and sulfone compounds
CN105294597B (en) * 2015-11-03 2017-11-24 华东师范大学 Benzothiazine derivatives and its synthetic method and application
US11155542B2 (en) 2016-09-22 2021-10-26 University Of Notre Dame Du Lac Antimicrobial compounds, their use for the treatment of mammalian infections and a new metabolic mechanism
CN108456204B (en) * 2017-02-17 2023-05-26 四川大学 Benzothiazine derivative, and preparation method and application thereof
CN108947952B (en) * 2017-05-24 2021-09-21 中国医学科学院药物研究所 2-substituted amino-5-trifluoromethyl-8-nitrobenz (thio) pyran-4-ketone compound and preparation method and application thereof
CN114957232B (en) * 2021-05-28 2023-06-30 四川大学 Benzodihydro oxazine compound, preparation method thereof and anti-tuberculosis application

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0621693B8 (en) * 2006-05-24 2021-05-25 Leibniz Insititute For Natural Product Res And Infection Biology E V Hans Knoell Institut Hki benzothiazinone derivative compounds, pharmaceutical composition, and their use as antibacterial agents
EP2020406A1 (en) * 2007-07-16 2009-02-04 Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. Hans-Knöll-Institut New antimicrobial compounds, their synthesis and their use for treatment of mammalian infection

Also Published As

Publication number Publication date
WO2012162912A1 (en) 2012-12-06
EP2719691A1 (en) 2014-04-16
CN102276598B (en) 2014-11-05
RU2013157860A (en) 2015-07-10
CN102276598A (en) 2011-12-14
US20140303152A1 (en) 2014-10-09

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