IN2013DE03349AIN3349DE2013AIN2013DE03349AIN 2013DE03349 AIN2013DE03349 AIN 2013DE03349AIN 3349DE2013 AIN3349DE2013 AIN 3349DE2013AIN 2013DE03349 AIN2013DE03349 AIN 2013DE03349A
Authority
IN
India
Prior art keywords
formula
preparation
dimethoxybenzocyclobutane
ivabradine
dimethoxybenzene
Prior art date
Application number
Inventor
Rajesh Vinodrai Naik
Gurdeep Singh Sarin
Pranav Gupta
Dilpreet Singh
Original Assignee
Ind Swift Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind Swift Lab LtdfiledCriticalInd Swift Lab Ltd
Priority to PCT/IN2014/000522priorityCriticalpatent/WO2015022702A2/en
Priority to IN3349DE2013prioritypatent/IN2013DE03349A/en
Publication of IN2013DE03349ApublicationCriticalpatent/IN2013DE03349A/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
The present invention relates to an efficient and industrially advantageous process for preparation of 3-(2-bromo-4,5-dimethoxybenzene)propionitrile of formula I, with high purity and high yield,wherein compound of formula I is an important precursor of 1-cyano-4,5- dimethoxybenzocyclobutane, a key intermediate in the preparation of ivabradine or its pharmaceutically acceptable salts thereof.
New process for the synthesis of (2e)-3-(3,4-dimethoxyphenyl)prop-2-enenitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
Novel process for synthesis of 3-(2-bromo-4,5-dimethoxyphenyl)pr opanenitrile, and application to the synthesis of ivabradine and of addition salts thereof with a pharmaceutically acceptable acid.
Process for the synthesis of 3,4-dimethoxybicyclo[4.2.0]octa-1,3, 5-triene-7-carbonitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.
Process for the synthesis of 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile and process for the synthesis of ivabradine and addition salts thereof with the use thereof
Process for the enzymatic synthesis of (7s)-3,4-dimethoxybicyclo[ 4.2.0]octa-1,3,5-triene-7-carboxylic acid and application in the synthesis of ivabradine and salts thereof.