IN2013DE03047A - - Google Patents

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Publication number
IN2013DE03047A
IN2013DE03047A IN3047DE2013A IN2013DE03047A IN 2013DE03047 A IN2013DE03047 A IN 2013DE03047A IN 3047DE2013 A IN3047DE2013 A IN 3047DE2013A IN 2013DE03047 A IN2013DE03047 A IN 2013DE03047A
Authority
IN
India
Prior art keywords
polysaccharide
present
protein
relates
group
Prior art date
Application number
Inventor
Davinder Gill
Manoj Kumar Chhikara
Rakesh Rana
Juned Dala
Deepti Singh
Vibhu Kanchan
Original Assignee
Msd Wellcome Trust Hilleman Lab Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msd Wellcome Trust Hilleman Lab Pvt Ltd filed Critical Msd Wellcome Trust Hilleman Lab Pvt Ltd
Priority to MYPI2016701265A priority Critical patent/MY194920A/en
Priority to IN3047DE2013 priority patent/IN2013DE03047A/en
Priority to PCT/IB2014/065201 priority patent/WO2015052684A2/en
Priority to CN201480056001.6A priority patent/CN105636608A/en
Publication of IN2013DE03047A publication Critical patent/IN2013DE03047A/en
Priority to ZA2016/02375A priority patent/ZA201602375B/en

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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to polysaccharide – protein conjugates with enhanced immunogenicity displaying significantly high antibody titres. The carrier protein is obtained from group of gram positive bacteria, polysaccharide fragment is obtained from group of gram negative bacteria, preferably from Haemophilus influenzae serotype b (Hib), Neisseria meningitidis serogroup A and C (MenA and MenC). The present invention also relates to a rapid and high yielding process of preparing the polysaccharide–protein conjugates in which derivatized carrier protein reacts with cleaved and depolymerized polysaccharide fragments of optimum length to obtain polysaccharide – protein conjugate employing reductive amination chemistry. The present invention further relates to a chemical process of polysaccharide fragmentation to optimum length for use in conjugation.
IN3047DE2013 2013-10-11 2014-10-10 IN2013DE03047A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
MYPI2016701265A MY194920A (en) 2013-10-11 2014-10-10 Polysaccharide ? protein conjugates with enhanced immunogenicity and rapid high yielding process thereof
IN3047DE2013 IN2013DE03047A (en) 2013-10-11 2014-10-10
PCT/IB2014/065201 WO2015052684A2 (en) 2013-10-11 2014-10-10 Polysaccharide-protein conjugates with enhanced immunogenicity and rapid high yielding process thereof
CN201480056001.6A CN105636608A (en) 2013-10-11 2014-10-10 Polysaccharide-protein conjugates with enhanced immunogenicity and rapid high yielding process thereof
ZA2016/02375A ZA201602375B (en) 2013-10-11 2016-04-08 Polysaccharide-protein conjugates with enhanced immunogenicity and rapid high yielding process of preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN3047DE2013 IN2013DE03047A (en) 2013-10-11 2014-10-10

Publications (1)

Publication Number Publication Date
IN2013DE03047A true IN2013DE03047A (en) 2015-04-17

Family

ID=54397097

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3047DE2013 IN2013DE03047A (en) 2013-10-11 2014-10-10

Country Status (1)

Country Link
IN (1) IN2013DE03047A (en)

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