IN2013CN09764A - - Google Patents

Info

Publication number
IN2013CN09764A
IN2013CN09764A IN9764CHN2013A IN2013CN09764A IN 2013CN09764 A IN2013CN09764 A IN 2013CN09764A IN 9764CHN2013 A IN9764CHN2013 A IN 9764CHN2013A IN 2013CN09764 A IN2013CN09764 A IN 2013CN09764A
Authority
IN
India
Prior art keywords
alkyl
hydrogen
formula
alkylheterocyclylalkyl
ch2cn
Prior art date
Application number
Inventor
Prasad V Chaturvedula
S Roy Kimura
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IN2013CN09764A publication Critical patent/IN2013CN09764A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A compound of formula (I) pharmaceutical^ acceptable salt thereof, wherein Rl is selected from hydrogen, Ci-C6 alkyl; Ci-C6 alkyl(C3-C8)cycloalkyl; Ci- C6 hydroxyalkyl; CH2CN; CH2C(0)NH2; Ci-C6 arylalkyl; and Ci-C6 10 alkylheterocyclylalkyl; R'-R° are independently selected from hydrogen, Ci-Ce alkoxy; and halo; and 7 R is a heteroaromatic group of formula (II) containing from 2 to 4 nitrogen atoms: Y^Z C3I6>
IN9764CHN2013 2011-06-21 2012-06-20 IN2013CN09764A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161499360P 2011-06-21 2011-06-21
PCT/US2012/043310 WO2012177738A1 (en) 2011-06-21 2012-06-20 Imidazole derivatives as inhibitors of pde10

Publications (1)

Publication Number Publication Date
IN2013CN09764A true IN2013CN09764A (en) 2015-04-03

Family

ID=46420554

Family Applications (1)

Application Number Title Priority Date Filing Date
IN9764CHN2013 IN2013CN09764A (en) 2011-06-21 2012-06-20

Country Status (3)

Country Link
US (1) US8592423B2 (en)
IN (1) IN2013CN09764A (en)
WO (1) WO2012177738A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2861596B1 (en) * 2012-06-19 2019-03-20 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
ES2480341B1 (en) 2013-01-24 2015-01-22 Palobiofarma S.L New derivatives of pyrimidine as phosphodiesterase 10 (PDE-10) inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT100905A (en) 1991-09-30 1994-02-28 Eisai Co Ltd BICYCLE HYGIENEOUS HETEROCYCLIC COMPOUNDS CONTAINING BENZENE, CYCLOHEXAN OR PYRIDINE AND PYRIMIDINE, PYRIDINE OR IMIDAZOLE SUBSTITUTES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US20030032579A1 (en) 2001-04-20 2003-02-13 Pfizer Inc. Therapeutic use of selective PDE10 inhibitors
CN1894241A (en) 2002-08-09 2007-01-10 阿斯利康(瑞典)有限公司 '1,2,4' oxadiazoles as modulators of metabotropic glutamate receptor-5
CN1805945A (en) 2003-04-18 2006-07-19 麦克公司 Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers
EP1741708A1 (en) 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Heteroaryl-substituted amides comprising an unsaturated or cyclic linker group, and their use as pharmaceuticals
US8133897B2 (en) 2008-06-20 2012-03-13 H. Lundbeck A/S Phenylimidazole derivatives as PDE10A enzyme inhibitors
TW201200516A (en) 2009-12-17 2012-01-01 Lundbeck & Co As H Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors
AR080754A1 (en) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv IMIDAZO DERIVATIVES (1,2-A) PIRAZINA AND ITS USE AS PDE10 INHIBITORS

Also Published As

Publication number Publication date
US8592423B2 (en) 2013-11-26
US20130150371A1 (en) 2013-06-13
WO2012177738A1 (en) 2012-12-27

Similar Documents

Publication Publication Date Title
PH12017501192A1 (en) Certain amino-pyridazines, compositions thereof, and methods of their use
TW201129556A (en) Novel antiplatelet agent
PH12016502037A1 (en) Certain amino-pyrimidines, compositions thereof, and methods for their use
MD20140023A2 (en) Pyrrolopyrimidine and purine derivatives
IN2012DN01325A (en)
GEP201706728B (en) Noxious organism control agent
EA024194B8 (en) Diarylacetylene hydrazide containing tyrosine kinase inhibitors
MY172924A (en) Neprilysin inhibitors
TN2011000404A1 (en) Fused pyrimidines
MX369801B (en) Halogen-substituted heterocyclic compound.
PH12014502180A1 (en) Novel thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof
JO3067B1 (en) Pyrazolylaminopyridines as inhibitors of fak
MX2015007883A (en) Compounds for protection of cells.
PH12015501215A1 (en) Novel selective androgen receptor modulators
MX343077B (en) Novel octahydrothienoquinoline derivative, pharmaceutical composition comprising derivative, and use of these.
IN2013CN09764A (en)
MY167897A (en) A compound separated from monascus-fermented rice, the preparation method and uses thereof
TN2014000519A1 (en) Pyrimidinone derivatives as antimalarial agents
IN2015DN02514A (en)
MX342390B (en) Process for the preparation of 3-haloalkylpyrazoles.
JO2948B1 (en) New dihydro-oxazolobenzodiazepinone compounds, a process for their preparation and pharmaceutical compositions containing them
UA105320C2 (en) Dihydrobenzoxathiazepine compounds, a process for their preparation and pharmaceutical compositions containing them
SA113350044B1 (en) Quinazolinone analogues for use as anticonvulsant agents
UA107357C2 (en) (6-oxo-1,6-dihydropyrimidine-2-il)amide derivatives, their preparation and their pharmaceutical use as inhibitors of phosphorylation akt (pkb)
TN2010000350A1 (en) New dihydroindolone compounds a process for their preparation and pharmaceutical compositions containing them