IN2013CN00342A - - Google Patents
Info
- Publication number
- IN2013CN00342A IN2013CN00342A IN342CHN2013A IN2013CN00342A IN 2013CN00342 A IN2013CN00342 A IN 2013CN00342A IN 342CHN2013 A IN342CHN2013 A IN 342CHN2013A IN 2013CN00342 A IN2013CN00342 A IN 2013CN00342A
- Authority
- IN
- India
- Prior art keywords
- carrier
- agent
- renal fibrosis
- treating renal
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6919—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a ribbon or a tubule cochleate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Abstract
Provided is a carrier for delivering a substance to extracellular matrix producing cells in the kidneys the carrier containing a retinoid as the targeting agent. Also provided is an agent for treating renal fibrosis that uses the carrier. Further provided are methods for producing the carrier and the agent production kits and a method and the like for treating renal fibrosis using the same agent for treating renal fibrosis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010138070 | 2010-06-17 | ||
PCT/JP2011/063910 WO2011158933A1 (en) | 2010-06-17 | 2011-06-17 | Agent for treating renal fibrosis |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2013CN00342A true IN2013CN00342A (en) | 2015-07-03 |
Family
ID=45348325
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN342CHN2013 IN2013CN00342A (en) | 2010-06-17 | 2011-06-17 |
Country Status (12)
Country | Link |
---|---|
US (2) | US20130136789A1 (en) |
EP (1) | EP2583691B1 (en) |
JP (2) | JP2012020995A (en) |
KR (1) | KR101967868B1 (en) |
CN (1) | CN102933233A (en) |
AU (1) | AU2011266057B2 (en) |
CA (1) | CA2802414C (en) |
ES (1) | ES2712086T3 (en) |
IN (1) | IN2013CN00342A (en) |
RU (2) | RU2711531C2 (en) |
TW (1) | TWI549691B (en) |
WO (1) | WO2011158933A1 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009221164A (en) | 2008-03-17 | 2009-10-01 | Nitto Denko Corp | Drug for treating pulmonary fibrosis |
US9572886B2 (en) | 2005-12-22 | 2017-02-21 | Nitto Denko Corporation | Agent for treating myelofibrosis |
JP5950428B2 (en) | 2010-08-05 | 2016-07-13 | 日東電工株式会社 | Composition for regenerating normal tissue from fibrotic tissue |
JP6340162B2 (en) | 2012-12-20 | 2018-06-06 | 日東電工株式会社 | Apoptosis inducer |
CA2935334C (en) | 2013-01-18 | 2021-05-25 | Cornell University | Methods of treating diseases associated with high fat diet and vitamin a deficiency using retinoic acid receptor agonists |
US9976142B2 (en) | 2014-04-02 | 2018-05-22 | Nitto Denko Corporation | Targeting molecule and a use thereof |
JP6480467B2 (en) | 2014-04-07 | 2019-03-13 | 日東電工株式会社 | Novel polymer based hydrotrope for hydrophobic drug delivery |
CN105597085A (en) * | 2015-12-17 | 2016-05-25 | 哈尔滨博翱生物医药技术开发有限公司 | Application of fibroblast growth factor-21 in treatment of renal fibrosis |
JP6833456B2 (en) * | 2016-11-02 | 2021-02-24 | 日東電工株式会社 | Skin fibrosis treatment agent |
KR102352489B1 (en) | 2019-12-09 | 2022-01-18 | 전남대학교산학협력단 | Hydrophobically modified glycol chitosan nanoparticle and renal targeted drug delivery system using the same |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5238924A (en) | 1984-05-03 | 1993-08-24 | Merck & Co., Inc. | Treatment of renal diseases with ace inhibitors |
JP3810020B2 (en) | 1993-04-22 | 2006-08-16 | 武田薬品工業株式会社 | Preventive or therapeutic agent for kidney disease |
US6183774B1 (en) * | 1996-01-31 | 2001-02-06 | Collaborative Laboratories, Inc. | Stabilizing vitamin A derivatives by encapsulation in lipid vesicles formed with alkylammonium fatty acid salts |
US6334999B1 (en) * | 1999-08-27 | 2002-01-01 | Research Development Foundation | Liposomal aerosols for delivery of chemotherapeutic retinoids to the lungs |
DK1132086T3 (en) | 2000-01-31 | 2006-08-28 | Pfizer Prod Inc | Use of prostaglandin (PGE2) selective receptor 4 (EP4) agonists for the treatment of acute and chronic renal failure |
BR0006556A (en) * | 2000-12-28 | 2002-09-17 | Apsen Farmaceutica S A | Pharmaceutical composition for topical use of corticosteroids for the treatment of phimosis |
IL143366A0 (en) | 2001-05-24 | 2002-04-21 | Harasit Medical Res Services & | Treatment of renal fibrosis |
JP2004043459A (en) | 2002-05-24 | 2004-02-12 | Sumitomo Pharmaceut Co Ltd | MEDICINE COMPRISING LOW MOLECULAR COMPOUND HAVING TGF-beta INHIBITION ACTIVITY |
EP1454625A1 (en) | 2003-03-06 | 2004-09-08 | Speedel Development AG | Pyridylsulfonamidyl-pyrimidines for the treatment of diabetic nephropathies |
EP1746885A4 (en) | 2004-05-03 | 2010-09-08 | Univ Virginia | Agonists of a2a adenosine receptors for treatment of diabetic nephropathy |
KR100613342B1 (en) | 2004-12-16 | 2006-08-21 | 동부일렉트로닉스 주식회사 | Semiconductor device and method of manufacturing the same |
JP2009221164A (en) * | 2008-03-17 | 2009-10-01 | Nitto Denko Corp | Drug for treating pulmonary fibrosis |
DK1842557T3 (en) * | 2004-12-22 | 2013-12-02 | Nitto Denko Corp | Drug carrier and drug carrier kit for inhibiting fibrosis |
JP2007099641A (en) | 2005-09-30 | 2007-04-19 | Tsumura & Co | Indolequinoxaline compound, method for producing the same and pharmaceutical composition using the same |
JP5342834B2 (en) * | 2008-09-05 | 2013-11-13 | 日東電工株式会社 | Treatment agent for myelofibrosis |
JP2009292725A (en) | 2006-09-01 | 2009-12-17 | Stelic Institute Of Regenerative Medicine | Kidney disease-improving agent |
TWI407971B (en) * | 2007-03-30 | 2013-09-11 | Nitto Denko Corp | Cancer cells and tumor-related fibroblasts |
JP2009007258A (en) | 2007-06-26 | 2009-01-15 | Kowa Pharmaceutical Co Ltd | 3-anilino-2-cycloalkenone derivative having inhibitory action on production of pai-1 |
JP2009029750A (en) | 2007-07-27 | 2009-02-12 | Kowa Co | Agent comprising arylpropane derivative as effective ingredient for inhibiting formation of advanced glycation end product |
WO2009036368A2 (en) * | 2007-09-14 | 2009-03-19 | Nitto Denko Corporation | Drug carriers |
JP2009178143A (en) | 2008-02-01 | 2009-08-13 | Stelic Institute Of Regenerative Medicine | Steatohepatitis-liver cancer model animal |
KR20110051214A (en) * | 2008-07-30 | 2011-05-17 | 닛토덴코 가부시키가이샤 | Drug carriers |
JP5744723B2 (en) * | 2008-09-12 | 2015-07-08 | 日東電工株式会社 | Imaging agent for fibrotic diseases |
JP2010077101A (en) | 2008-09-29 | 2010-04-08 | Toray Ind Inc | Curative or preventive agent for kidney fibrosis |
TWI465238B (en) * | 2009-12-09 | 2014-12-21 | Nitto Denko Corp | Modulation of hsp47 expression |
DK2718261T3 (en) * | 2011-06-08 | 2016-03-29 | Nitto Denko Corp | Compounds to target drug delivery and promote siRNA activity |
-
2011
- 2011-06-17 WO PCT/JP2011/063910 patent/WO2011158933A1/en active Application Filing
- 2011-06-17 IN IN342CHN2013 patent/IN2013CN00342A/en unknown
- 2011-06-17 CN CN2011800279298A patent/CN102933233A/en active Pending
- 2011-06-17 RU RU2017136720A patent/RU2711531C2/en active
- 2011-06-17 JP JP2011134708A patent/JP2012020995A/en active Pending
- 2011-06-17 US US13/704,437 patent/US20130136789A1/en not_active Abandoned
- 2011-06-17 TW TW100121244A patent/TWI549691B/en active
- 2011-06-17 KR KR1020137001156A patent/KR101967868B1/en active IP Right Grant
- 2011-06-17 RU RU2013101969A patent/RU2635460C2/en active
- 2011-06-17 EP EP11795835.5A patent/EP2583691B1/en active Active
- 2011-06-17 AU AU2011266057A patent/AU2011266057B2/en active Active
- 2011-06-17 ES ES11795835T patent/ES2712086T3/en active Active
- 2011-06-17 CA CA2802414A patent/CA2802414C/en active Active
-
2015
- 2015-03-25 US US14/668,618 patent/US20150259683A1/en not_active Abandoned
- 2015-05-18 JP JP2015100873A patent/JP5873589B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP2015155459A (en) | 2015-08-27 |
EP2583691A4 (en) | 2016-04-27 |
RU2635460C2 (en) | 2017-11-13 |
US20130136789A1 (en) | 2013-05-30 |
EP2583691B1 (en) | 2019-01-16 |
KR20130121813A (en) | 2013-11-06 |
AU2011266057B2 (en) | 2014-12-04 |
TW201204389A (en) | 2012-02-01 |
TWI549691B (en) | 2016-09-21 |
RU2711531C2 (en) | 2020-01-17 |
CN102933233A (en) | 2013-02-13 |
JP2012020995A (en) | 2012-02-02 |
CA2802414C (en) | 2018-01-09 |
CA2802414A1 (en) | 2011-12-22 |
RU2013101969A (en) | 2014-07-27 |
US20150259683A1 (en) | 2015-09-17 |
ES2712086T3 (en) | 2019-05-09 |
RU2017136720A3 (en) | 2019-02-08 |
AU2011266057A1 (en) | 2013-01-10 |
WO2011158933A1 (en) | 2011-12-22 |
RU2017136720A (en) | 2019-02-08 |
JP5873589B2 (en) | 2016-03-01 |
EP2583691A1 (en) | 2013-04-24 |
KR101967868B1 (en) | 2019-08-19 |
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