IN2013CH05359AIN5359CH2013AIN2013CH05359AIN 2013CH05359 AIN2013CH05359 AIN 2013CH05359AIN 5359CH2013 AIN5359CH2013 AIN 5359CH2013AIN 2013CH05359 AIN2013CH05359 AIN 2013CH05359A
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IN
India
Prior art keywords
aprepitant
formula
preparation
present application
relates
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Inventor
Iqbal Javed
Oruganti Srinivas
Kumar Rapolu Rajesh
Hareshwar Dahanukar Vilas
Ravi Ram Chandrashekar Elati
Shamrao Metil Dattatray
Naram Jyothirmayi
Prapulla Kumar Palavi
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Reddy’S Lab Ltd Dr
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Priority to IN5359CH2013priorityCriticalpatent/IN2013CH05359A/en
Publication of IN2013CH05359ApublicationCriticalpatent/IN2013CH05359A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
The present application relates to a process for the preparation of (R)-4-benzyl-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)morpholin-3-one of formula (I), which may be used as an intermediate of aprepitant of formula (V). The present application also relates to a process for the preparation of aprepitant (V).
CRYSTAL FORM OF THE COMPOUND (S)-3-{4-[5-(2-CYCLOPENTYL-6-METHOXY- PYRIDIN-4- YL)-[1,2,4]OXADIAZOL-3- YL]-2- ETHYL- 6-METHYL- PHENOXY}-PROPANE-1,2-DIOL
Method for synthesising 4-piperidin-4-yl-benzene-1,3-diol and the salts of same and novel compound tert-butyl 4-(2,4-dihydroxy-phenyl)-4-hydroxy-piperidine-1-carboxylate