IN2012DN06278A - - Google Patents

Info

Publication number
IN2012DN06278A
IN2012DN06278A IN6278DEN2012A IN2012DN06278A IN 2012DN06278 A IN2012DN06278 A IN 2012DN06278A IN 6278DEN2012 A IN6278DEN2012 A IN 6278DEN2012A IN 2012DN06278 A IN2012DN06278 A IN 2012DN06278A
Authority
IN
India
Prior art keywords
polypeptides
directed
present
use production
microalgal cells
Prior art date
Application number
Inventor
Kirk E Apt
Anne Cecile V BAYNE
James Casey Lippmeier
Xuan Guo
Joyce A Pritchard
Original Assignee
Dsm Ip Assets Bv
Merial Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv, Merial Ltd filed Critical Dsm Ip Assets Bv
Publication of IN2012DN06278A publication Critical patent/IN2012DN06278A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18151—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
    • C12N2760/18651—Methods of production or purification of viral material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The present invention is directed to recombinant microalgal cells and their use production of heterologous hemagglutinin neuraminidase (HN) polypeptides as well compositions and uses thereof.
IN6278DEN2012 2009-12-28 2010-12-28 IN2012DN06278A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29046909P 2009-12-28 2009-12-28
PCT/US2010/062274 WO2011082189A1 (en) 2009-12-28 2010-12-28 Production of hemagglutinin-neuraminidase protein in microalgae

Publications (1)

Publication Number Publication Date
IN2012DN06278A true IN2012DN06278A (en) 2015-09-25

Family

ID=44226795

Family Applications (1)

Application Number Title Priority Date Filing Date
IN6278DEN2012 IN2012DN06278A (en) 2009-12-28 2010-12-28

Country Status (9)

Country Link
US (1) US9012197B2 (en)
EP (1) EP2519636B8 (en)
JP (1) JP5838473B2 (en)
CN (1) CN103068984B (en)
AU (1) AU2010339544B2 (en)
CA (1) CA2785867C (en)
EA (1) EA030095B1 (en)
IN (1) IN2012DN06278A (en)
WO (1) WO2011082189A1 (en)

Families Citing this family (12)

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Publication number Priority date Publication date Assignee Title
TWI324181B (en) 2001-04-16 2010-05-01 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
WO2010107709A1 (en) * 2009-03-16 2010-09-23 Martek Biosciences Corporation Protein production in microorganisms of the phylum labyrinthulomycota
JP5933451B2 (en) * 2009-12-28 2016-06-08 メリアル リミテッド Recombinant NDV antigen and uses thereof
EA022841B1 (en) * 2009-12-28 2016-03-31 ДиЭсЭм АйПи АССЕТС Б.В. PREPARATION OF HETEROLOGICAL POLYPEPTIDES IN MICROWATEREDES, EXTRA-CELLED MICROWAVE-ALONG CALVES, COMPOSITIONS AND METHODS OF THEIR RECEIVING AND APPLICATION
MX343403B (en) 2010-01-19 2016-11-03 Dsm Ip Assets B V * Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof.
BR122015020126B1 (en) * 2011-07-21 2022-03-03 Dsm Ip Assets B.V COMPOSITION CONTAINING DILUTED MICROBIAL OIL
CN103525785B (en) * 2013-09-24 2015-03-25 西北大学 Method for separating and purifying neuraminidase (avian influenza virus)
CA2977271A1 (en) 2015-03-02 2016-09-09 Synthetic Genomics, Inc. Regulatory elements from labyrinthulomycetes microorganisms
EP3535385A4 (en) 2016-11-01 2020-06-17 Conagen Inc. Expression of modified glycoproteins and glycopeptides
US10633454B2 (en) 2016-11-01 2020-04-28 Conagen Inc. Expression of modified glycoproteins and glycopeptides
WO2019213095A1 (en) * 2018-05-01 2019-11-07 Conagen Inc. Recombinant organisms and methods for producing glycomolecules with high glycan occupancy
KR20240118798A (en) 2021-11-30 2024-08-05 사노피 파스퇴르 인크 Human metapneumovirus vaccine

Family Cites Families (26)

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US4659669A (en) 1981-03-02 1987-04-21 Regents Of The Univ. Of California Microbial expression of human influenza hemagglutinin proteins
US4752473A (en) 1984-10-12 1988-06-21 The Regents Of The University Of California Expression of glycosylated human influenza hemagglutinin proteins
US5340742A (en) 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
US5762939A (en) 1993-09-13 1998-06-09 Mg-Pmc, Llc Method for producing influenza hemagglutinin multivalent vaccines using baculovirus
US6027900A (en) * 1996-04-12 2000-02-22 Carnegie Institution Of Washington Methods and tools for transformation of eukaryotic algae
AU8246298A (en) 1997-07-08 1999-02-08 Stichting Instituut Voor Dierhouderij En Diergezondheid Epitopes and active sites of paramyxoviridae proteins and uses thereof
US8003772B2 (en) * 1999-01-14 2011-08-23 Martek Biosciences Corporation Chimeric PUFA polyketide synthase systems and uses thereof
US20060257399A1 (en) 2000-06-28 2006-11-16 Glycofi, Inc. Immunoglobulins comprising predominantly a Man5GIcNAc2 glycoform
US20060029604A1 (en) 2000-06-28 2006-02-09 Gerngross Tillman U Immunoglobulins comprising predominantly a GlcNAc2Man3GlcNAc2 glycoform
US7625756B2 (en) 2000-06-28 2009-12-01 GycoFi, Inc. Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells
NZ523476A (en) 2000-06-28 2004-04-30 Glycofi Inc Methods for humanizing glycosylation of recombinant glycoproteins expressed in lower eukaryotes
US7795002B2 (en) 2000-06-28 2010-09-14 Glycofi, Inc. Production of galactosylated glycoproteins in lower eukaryotes
TWI324181B (en) * 2001-04-16 2010-05-01 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
US7332299B2 (en) 2003-02-20 2008-02-19 Glycofi, Inc. Endomannosidases in the modification of glycoproteins in eukaryotes
AU2004235813B2 (en) 2003-05-05 2010-07-29 Boyce Thompson Institute For Plant Research Vectors and cells for preparing immunoprotective compositions derived from transgenic plants
PT1629004E (en) * 2003-06-05 2008-11-14 Wyeth Corp Immunogenic compositions comprising venezuelan equine encephalitis virus replicon vectors and paramyxovirus protein antigens
US7527800B2 (en) 2004-05-25 2009-05-05 Medimmune, Llc Influenza hemagglutinin and neuraminidase variants
EP1789530B1 (en) * 2004-08-05 2015-10-07 Ben Gurion University of the Negev Research and Development Autority Red microalgae expressing exogenous polypeptides and methods of generating and utilizing same
JP4796787B2 (en) * 2005-04-28 2011-10-19 富士フイルム株式会社 Gene transfer to Labyrinthula
JP4796786B2 (en) * 2005-04-28 2011-10-19 富士フイルム株式会社 A vector capable of transforming Labyrinthula
MX339812B (en) 2006-03-15 2016-06-08 Dsm Ip Assets B V * Polyunsaturated fatty acid production in heterologous organisms using pufa polyketide synthase systems.
CA2615372A1 (en) 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
EP2090648A1 (en) * 2008-02-12 2009-08-19 Institut Francais de Recherche pour l'Exploitation de la Mere(Ifremer) Production of glycosylated polypeptides in microalgae
WO2010107709A1 (en) 2009-03-16 2010-09-23 Martek Biosciences Corporation Protein production in microorganisms of the phylum labyrinthulomycota
JP5933451B2 (en) 2009-12-28 2016-06-08 メリアル リミテッド Recombinant NDV antigen and uses thereof
EA022841B1 (en) 2009-12-28 2016-03-31 ДиЭсЭм АйПи АССЕТС Б.В. PREPARATION OF HETEROLOGICAL POLYPEPTIDES IN MICROWATEREDES, EXTRA-CELLED MICROWAVE-ALONG CALVES, COMPOSITIONS AND METHODS OF THEIR RECEIVING AND APPLICATION

Also Published As

Publication number Publication date
EP2519636B8 (en) 2017-08-09
AU2010339544A1 (en) 2012-08-09
EA030095B1 (en) 2018-06-29
CA2785867A1 (en) 2011-07-07
CA2785867C (en) 2018-03-27
US9012197B2 (en) 2015-04-21
JP2013515502A (en) 2013-05-09
EA201290565A1 (en) 2013-02-28
CN103068984B (en) 2017-12-01
EP2519636A4 (en) 2013-07-03
AU2010339544B2 (en) 2015-11-12
EP2519636A1 (en) 2012-11-07
CN103068984A (en) 2013-04-24
WO2011082189A1 (en) 2011-07-07
EP2519636B1 (en) 2017-03-01
JP5838473B2 (en) 2016-01-06
US20110195480A1 (en) 2011-08-11

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