IN2012DN04965A - - Google Patents

Download PDF

Info

Publication number
IN2012DN04965A
IN2012DN04965A IN4965DEN2012A IN2012DN04965A IN 2012DN04965 A IN2012DN04965 A IN 2012DN04965A IN 4965DEN2012 A IN4965DEN2012 A IN 4965DEN2012A IN 2012DN04965 A IN2012DN04965 A IN 2012DN04965A
Authority
IN
India
Prior art keywords
certain embodiments
zeolites
post
cations
disclosed
Prior art date
Application number
Inventor
J Crudden Joseph
Johns Derrick
Original Assignee
Difusion Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44067221&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2012DN04965(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Difusion Technologies Inc filed Critical Difusion Technologies Inc
Publication of IN2012DN04965A publication Critical patent/IN2012DN04965A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02Inorganic materials
    • A61L27/10Ceramics or glasses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/18Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/443Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with carbon fillers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56Porous materials, e.g. foams or sponges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20Targets to be treated
    • A61L2202/21Pharmaceuticals, e.g. medicaments, artificial body parts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104Silver, e.g. silver sulfadiazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Molecular Biology (AREA)
  • Ceramic Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Prostheses (AREA)
  • Treatment Of Water By Ion Exchange (AREA)
  • Dental Preparations (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Polymers & Plastics (AREA)

Abstract

Methods of post-loading ceramic particles with antimicrobial metal cations are disclosed. In certain embodiments, the post-loaded particles are zeolites, wherein the zeolites have been incorporated into a resin and the combination is used as an implantable device. In certain embodiments, the polymer is a thermoplastic polymer such as polyaryletheretherketone (PEEK). In certain embodiments, the source of antimicrobial activi ty includes ion-exchangeable cations contained in a zeolite. In certain embodiments, disclosed are methods of imparting antimicrobial activity to devices by controlling the delivery of certain cations through ion-exchange via a zeolite incorporated in the device.
IN4965DEN2012 2009-11-25 2010-11-24 IN2012DN04965A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26428909P 2009-11-25 2009-11-25
US30063110P 2010-02-02 2010-02-02
PCT/US2010/058009 WO2011066391A2 (en) 2009-11-25 2010-11-24 Post-charging of zeolite doped plastics with antimicrobial metal ions

Publications (1)

Publication Number Publication Date
IN2012DN04965A true IN2012DN04965A (en) 2015-09-25

Family

ID=44067221

Family Applications (1)

Application Number Title Priority Date Filing Date
IN4965DEN2012 IN2012DN04965A (en) 2009-11-25 2010-11-24

Country Status (7)

Country Link
US (4) US9492584B2 (en)
EP (1) EP2504041B1 (en)
CN (2) CN104941004B (en)
BR (1) BR112012012603B1 (en)
IN (1) IN2012DN04965A (en)
RU (1) RU2552939C2 (en)
WO (1) WO2011066391A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012016027B1 (en) 2009-12-11 2019-01-15 Difusion Technologies, Inc. production method of polyetheretherketone antimicrobial implants
CA2795836C (en) 2010-05-07 2015-11-17 Difusion Technologies, Inc. Medical implant comprising a thermoplastic resin having aluminosilicate particles incorporated therein
WO2014152653A1 (en) * 2013-03-14 2014-09-25 Difusion Technologies, Inc. Self sterilizing orthopedic implants
WO2014152649A1 (en) * 2013-03-15 2014-09-25 Difusion Technologies, Inc. Enhanced efficacy self-sterilizing orthopedic implants
WO2018148453A1 (en) * 2017-02-09 2018-08-16 Femasys, Inc. Methods and compositions comprising biodegradable cyanoacrylates
US11766339B1 (en) 2017-10-24 2023-09-26 Omnia Medical, LLC Multi-material multi-component spinal implant
US10736752B1 (en) 2017-10-24 2020-08-11 Omnia Medical, LLC Multi-material multi-component spinal implant
KR20200118087A (en) * 2018-02-02 2020-10-14 에보니크 오퍼레이션즈 게엠베하 Functional oblique polymer knee implant and fabrication for improved fixation, wear resistance, and mechanical properties
FR3084351B1 (en) 2018-07-26 2021-04-02 Enercat ZEOLITH DOPED BY A CATION OF TRANSITIONAL METAL AND MODIFIED BY A QUATERNARY AMMONIUM, PREPARATION AND USE
US11439726B2 (en) 2018-12-03 2022-09-13 Osseomimetic, LLC Surgical implants
US20210402052A1 (en) 2020-06-30 2021-12-30 Difusion, Inc. Medical Implants And Methods Of Manufacture
CN112608230A (en) * 2020-11-17 2021-04-06 银金达(上海)新材料有限公司 Low-metal-ion PETG material and application thereof
US20250242085A1 (en) * 2022-04-14 2025-07-31 Difusion, Inc. Surgical implants with enhanced osseointegration and methods of manufacture

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4088737A (en) 1976-11-02 1978-05-09 The United States Of America As Represented By The United States Department Of Energy Dry method for recycling iodine-loaded silver zeolite
EP0048246B1 (en) 1980-03-27 1986-05-28 National Research Development Corporation Antimicrobial surgical implants
DE3228849C2 (en) 1982-08-02 1989-06-08 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 8000 München Medical device to be inserted into the body
EP0124536A4 (en) 1982-11-05 1985-06-06 Baxter Travenol Lab Antimicrobial compositions.
JPS59133235A (en) * 1983-01-21 1984-07-31 Kanebo Ltd Zeolite particle-containing polymer and its production
US4596574A (en) 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
US4612337A (en) 1985-05-30 1986-09-16 The Trustees Of Columbia University In The City Of New York Method for preparing infection-resistant materials
GB2190383B (en) 1986-04-08 1990-03-28 Dentsply Ltd Glass/poly (carboxylic acid)cement compositions
JPS6323960A (en) 1986-07-16 1988-02-01 Zenji Hagiwara High molecular material containing amorphous aluminosilicate particle and production thereof
US4938958A (en) 1986-12-05 1990-07-03 Shinagawa Fuel Co., Ltd. Antibiotic zeolite
US4775586A (en) 1987-02-17 1988-10-04 Armstrong World Industries, Inc. Paper, paper products, films composites and other silicate-polymer, construction materials
JPS63265958A (en) * 1987-04-22 1988-11-02 Shinagawa Nenryo Kk Antibacterial resin composition
JPH0618899B2 (en) 1987-06-30 1994-03-16 品川燃料株式会社 Film containing antibacterial zeolite
JPH0741061B2 (en) 1987-07-09 1995-05-10 華郎 前田 Medical dressing
JPS6415056A (en) 1987-07-09 1989-01-19 Hanarou Maeda Body indwelling tube
JPH0688885B2 (en) * 1987-12-26 1994-11-09 品川燃料株式会社 Method for producing dispersion containing antibacterial powder
JP2512324B2 (en) 1988-11-24 1996-07-03 株式会社ジーシーデンタルプロダクツ Dental resin composition
US4957817A (en) 1988-11-25 1990-09-18 The Dow Chemical Film, fiber, and microporous membranes of poly(etheretherketone)dissolved in high boiling point polar organic solvents
US5632779A (en) 1989-07-25 1997-05-27 Smith & Nephew, Inc. Zirconium oxide and zirconium nitride coated vascular grafts
JP2811331B2 (en) 1989-10-02 1998-10-15 ゼリア新薬工業株式会社 Bone formation promoter
US5192590A (en) 1989-11-03 1993-03-09 Raychem Corporation Coating metal on poly(aryl ether ketone) surfaces
IL96313A (en) 1989-11-14 1995-03-30 Sangi Kk Antibacterial ceramic material
JPH03199403A (en) 1989-12-27 1991-08-30 Chugoku Pearl Hanbai Kk sterile gloves
US5256390A (en) 1990-07-03 1993-10-26 Ethyl Corporation Biocidal zeolite particles
US5296238A (en) 1991-02-26 1994-03-22 Toagosei Chemical Industry Co., Inc. Microbicides
US5282847A (en) 1991-02-28 1994-02-01 Medtronic, Inc. Prosthetic vascular grafts with a pleated structure
EP0677989B1 (en) 1991-08-09 1998-09-16 E.I. Du Pont De Nemours And Company Antimicrobial compositions, process for preparing the same and use
US5503840A (en) 1991-08-09 1996-04-02 E. I. Du Pont De Nemours And Company Antimicrobial compositions, process for preparing the same and use
US5180585A (en) 1991-08-09 1993-01-19 E. I. Du Pont De Nemours And Company Antimicrobial compositions, process for preparing the same and use
WO1993007924A1 (en) 1991-10-18 1993-04-29 Spire Corporation Bactericidal coatings for implants
JPH05124919A (en) 1991-11-05 1993-05-21 Sangi Co Ltd Antibacterial ceramics
JPH05230325A (en) 1992-02-24 1993-09-07 Polyplastics Co Antibacterial, antifungal polyacetal resin composition
US5681575A (en) 1992-05-19 1997-10-28 Westaim Technologies Inc. Anti-microbial coating for medical devices
US5492763A (en) 1992-06-08 1996-02-20 Spire Corporation Infection resistant medical devices and process
DE69320167T2 (en) 1992-12-25 1999-01-21 Japan Synthetic Rubber Co., Ltd., Tokio/Tokyo Antibacterial resin composition
US5522904A (en) 1993-10-13 1996-06-04 Hercules Incorporated Composite femoral implant having increased neck strength
US6180606B1 (en) 1994-09-28 2001-01-30 Gensci Orthobiologics, Inc. Compositions with enhanced osteogenic potential, methods for making the same and uses thereof
JP3121503B2 (en) 1994-10-18 2001-01-09 レンゴー株式会社 Antibacterial agent
JP2860951B2 (en) 1995-01-12 1999-02-24 株式会社萩原技研 Antimicrobial polymer composition
US5731087A (en) 1995-06-07 1998-03-24 Union Carbide Chemicals & Plastics Technology Corporation Lubricious coatings containing polymers with vinyl and carboxylic acid moieties
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
US5756145A (en) 1995-11-08 1998-05-26 Baylor College Of Medicine Durable, Resilient and effective antimicrobial coating for medical devices and method of coating therefor
DE69632996T2 (en) 1995-12-26 2005-07-21 Toyo Boseki K.K. Organic solvent-soluble mucopolysaccharides, antibacterial antithrombogenic agent and medical material
US6015816A (en) 1996-02-29 2000-01-18 The Research Foundation Of State University Of New York Antimicrobial compositions
US5688561A (en) 1996-04-16 1997-11-18 Kabushiki Kaisha Nippankenkyusho Coating method
WO1999009149A1 (en) 1997-08-01 1999-02-25 Massachusetts Institute Of Technology Three-dimensional polymer matrices
AU8846398A (en) 1997-08-11 1999-03-01 University Of Toronto Innovations Foundation, The Antimicrobial cement compositions
JP3143660B2 (en) 1997-11-27 2001-03-07 工業技術院長 Ceramics comprising zinc-containing tricalcium phosphate and sustained-release zinc bioceramics
AU5390699A (en) 1998-07-24 2000-02-14 Pharmacal Biotechnologies, Inc. Osseous tissue reconstruction system and method
US6248342B1 (en) 1998-09-29 2001-06-19 Agion Technologies, Llc Antibiotic high-pressure laminates
US6436422B1 (en) 1998-11-23 2002-08-20 Agion Technologies L.L.C. Antibiotic hydrophilic polymer coating
US6585767B1 (en) 1998-11-23 2003-07-01 Agion Technologies, Inc. Antimicrobial suturing ring for heart valve
US6296863B1 (en) 1998-11-23 2001-10-02 Agion Technologies, Llc Antimicrobial fabric and medical graft of the fabric
US6582715B1 (en) * 1999-04-27 2003-06-24 Agion Technologies, Inc. Antimicrobial orthopedic implants
US6723428B1 (en) 1999-05-27 2004-04-20 Foss Manufacturing Co., Inc. Anti-microbial fiber and fibrous products
EP1066825A1 (en) 1999-06-17 2001-01-10 The Procter & Gamble Company An anti-microbial body care product
US8323341B2 (en) 2007-09-07 2012-12-04 Intrinsic Therapeutics, Inc. Impaction grafting for vertebral fusion
US6267590B1 (en) 1999-11-24 2001-07-31 Agion Technologies, Llc Antimicrobial dental products
DE10037850A1 (en) 2000-08-01 2002-02-21 Herbert P Jennissen Process for the production of bioactive implant surfaces
US6866859B2 (en) 2000-08-30 2005-03-15 Biocoat Incorporated Bi-laminar, hyaluronan coatings with silver-based anti-microbial properties
DE10043151A1 (en) 2000-08-31 2002-03-28 Peter Steinruecke Bone cement with antimicrobial effectiveness
DE10055465A1 (en) 2000-11-09 2002-05-23 Blz Gmbh Material useful for making bone replacement implants comprises nonmetallic inorganic filler particles embedded in a laser-sinterable biocompatible polymer matrix
DE20020649U1 (en) 2000-12-06 2002-04-11 stryker Trauma GmbH, 24232 Schönkirchen Device for surgical or therapeutic use, in particular implants and surgical instruments and their accessories
CN1961666B (en) 2001-01-04 2011-06-22 拜奥特罗尔股份有限公司 Anti-microbial composition
JP2004536621A (en) 2001-01-30 2004-12-09 イソティス エス.エー. Method of applying a bioactive coating to a medical device
DE60138521D1 (en) 2001-02-27 2009-06-10 Co Ligne Ag Medical implant
JP2005511144A (en) 2001-12-03 2005-04-28 シー・アール・バード・インク Microbial-resistant medical device, microbial-resistant polymer coating and production method thereof
US7357949B2 (en) * 2001-12-21 2008-04-15 Agion Technologies Inc. Encapsulated inorganic antimicrobial additive for controlled release
RU2313370C2 (en) 2002-04-09 2007-12-27 Астра Тек АБ Medicinal prostheses of improved biological compatibility
DE10243132B4 (en) 2002-09-17 2006-09-14 Biocer Entwicklungs Gmbh Anti-infective, biocompatible titanium oxide coatings for implants and methods of making them
CA2501822C (en) 2002-10-08 2012-02-21 Osteotech, Inc. Coupling agents for orthopedic biomaterials
FR2848856B1 (en) 2002-12-24 2007-05-25 Cadorel Catherine MATERIAL FOR MEDICAL OR VETERINARY USE, PROCESS FOR OBTAINING SAME AND APPLICATIONS THEREOF
US20060259020A1 (en) * 2003-09-17 2006-11-16 Minnesota Scientific, Inc. Bacteria resistant coating for surgical instrument
WO2005027722A2 (en) 2003-09-17 2005-03-31 Minnesota Scientific, Inc. Bacteria resistant coating for surgical instrument
US20050149196A1 (en) 2004-01-07 2005-07-07 St. Francis Medical Technologies, Inc. Artificial spinal disk replacement device with rotation limiter and lateral approach implantation method
CA2553199C (en) 2004-01-12 2014-03-25 The Trustees Of The University Of Pennsylvania System for up-regulating bone morphogenetic protein (bmp) gene expression in bone cells via the application of fields generated by specific electric and electromagnetic signals
WO2006096167A1 (en) 2004-03-03 2006-09-14 Melnick, Benedetta, D. Minimally-invasive method for performing spinal fusion and bone graft capsule for facilitating the same
US9625065B2 (en) * 2004-09-03 2017-04-18 Loewenstein Medical Technology S.A. Plastics for medical technical devices
US20060069438A1 (en) 2004-09-29 2006-03-30 Zucherman James F Multi-piece artificial spinal disk replacement device with multi-segmented support plates
US7670384B2 (en) 2004-10-14 2010-03-02 Biomet Manufacturing Corp. Bone graft composition comprising a bone material and a carrier comprising denatured demineralized bone
EA011594B1 (en) 2004-12-30 2009-04-28 Синвеншен Аг Combination comprising an agent providing a signal, an implant material and a drug
US7858123B2 (en) 2005-04-04 2010-12-28 The Regents Of The University Of California Inorganic materials for hemostatic modulation and therapeutic wound healing
US7662186B2 (en) 2005-05-06 2010-02-16 Titan Spine, Llc Anterior interbody spinal implant
EP1909685A2 (en) 2005-05-26 2008-04-16 Zimmer Dental Inc. Prosthetic dental device
CA2612446A1 (en) 2005-07-01 2007-01-11 Cinvention Ag Process for the production of porous reticulated composite materials
WO2007019461A2 (en) 2005-08-08 2007-02-15 Angstrom Medica, Inc. Cement products and methods of making and using the same
JP2007091501A (en) 2005-09-27 2007-04-12 Sinanen Zeomic Co Ltd Antibacterial zeolite and antibacterial resin composition
WO2007056671A1 (en) 2005-11-02 2007-05-18 Osteotech, Inc. Hemostatic bone graft
EP1813292A1 (en) 2006-01-25 2007-08-01 Inion Oy Surgical implant and manufacturing method
GB0601687D0 (en) 2006-01-27 2006-03-08 Smith & Nephew Antimicrobial materials
ES2379989T3 (en) 2006-04-07 2012-05-07 Bactiguard Ab Novel antimicrobial substrates and their uses
US7879027B2 (en) 2006-04-24 2011-02-01 Warsaw Orthopedic, Inc. Controlled release devices for fusion of osteal structures
US7661430B2 (en) 2006-05-19 2010-02-16 Richard Mason Antimicrobial dental appliances including mouthguards and mouthpieces
US20080033572A1 (en) 2006-08-03 2008-02-07 Ebi L.P. Bone graft composites and methods of treating bone defects
WO2008039488A2 (en) 2006-09-25 2008-04-03 Vita Special Purpose Corporation Bioactive load-bearing composites
FR2906147B1 (en) 2006-09-26 2012-11-02 Biomatlante METHOD FOR SANDING BIOCOMPATIBLE POLYMERS
WO2008048266A1 (en) 2006-10-20 2008-04-24 Ticona Llc Polyether ether ketone/ polyphenylene sulfide blend
CN101234304A (en) * 2007-02-02 2008-08-06 中国科学院化学研究所 A kind of polyetheretherketone porous membrane and preparation method thereof
FR2912740B1 (en) 2007-02-21 2012-02-17 Cougoulic Catherine Cadorel POROUS COMPOSITE MATERIAL FOR BIOMEDICAL USE
WO2008104964A2 (en) 2007-02-26 2008-09-04 University Of Limerick A synthetic bone graft
WO2008122594A2 (en) 2007-04-05 2008-10-16 Cinvention Ag Partially biodegradable therapeutic implant for bone and cartilage repair
US20090012612A1 (en) 2007-04-10 2009-01-08 David White Devices and methods for push-delivery of implants
FR2915088B1 (en) 2007-04-18 2010-03-12 Cadorel Catherine COMPOSITE ENDO-BONE COMPOSITE IMPLANT WITH OPTIMIZED MECHANICAL ATTACHMENT AND METHOD FOR MANUFACTURING SUCH IMPLANT
JP6017110B2 (en) * 2007-05-29 2016-11-09 ティーピーケイ ホールディング カンパニー リミテッド Particle-containing surfaces and related methods
US9931438B2 (en) 2008-01-28 2018-04-03 Ngk Spark Plug Co., Ltd. Article with foamed surface, implant and method of producing the same
EP2238192B1 (en) * 2008-02-01 2017-03-01 Synthes GmbH Porous biocompatible polymer material and methods
US8014131B2 (en) * 2008-02-05 2011-09-06 Siemens Industry, Inc. Riser bus bar positioning block
US8545222B2 (en) 2008-10-21 2013-10-01 Chan Qian Wang Method of dental implant restoration
KR20170121209A (en) 2009-02-25 2017-11-01 오소본드 코포레이션 Anti-infective funtionalized surfaces and methods of making same
CN102387782B (en) 2009-04-01 2013-10-30 扩散技术公司 Regulation of bone growth using zeolite in combination with bone graft substitutes
DE102009023459B4 (en) 2009-06-02 2017-08-31 Aap Implantate Ag Osteosynthesis with nanosilver
BR112012016027B1 (en) 2009-12-11 2019-01-15 Difusion Technologies, Inc. production method of polyetheretherketone antimicrobial implants
ES2664944T3 (en) 2009-12-23 2018-04-24 Fundacion Inasmet Porous PEEK article as an implant
CA2795836C (en) 2010-05-07 2015-11-17 Difusion Technologies, Inc. Medical implant comprising a thermoplastic resin having aluminosilicate particles incorporated therein
WO2014152649A1 (en) 2013-03-15 2014-09-25 Difusion Technologies, Inc. Enhanced efficacy self-sterilizing orthopedic implants

Also Published As

Publication number Publication date
WO2011066391A3 (en) 2011-10-06
CN104941004A (en) 2015-09-30
US20200338237A1 (en) 2020-10-29
RU2012126078A (en) 2013-12-27
CN102802685A (en) 2012-11-28
EP2504041A2 (en) 2012-10-03
EP2504041B1 (en) 2017-04-12
US20170021061A1 (en) 2017-01-26
WO2011066391A2 (en) 2011-06-03
BR112012012603A2 (en) 2017-11-21
BR112012012603B1 (en) 2019-03-19
CN102802685B (en) 2015-05-27
RU2552939C2 (en) 2015-06-10
CN104941004B (en) 2018-09-14
US9492584B2 (en) 2016-11-15
EP2504041A4 (en) 2013-06-19
US20120315340A1 (en) 2012-12-13
US20200338238A1 (en) 2020-10-29

Similar Documents

Publication Publication Date Title
IN2012DN04965A (en)
NZ593688A (en) Micrornas that regulate muscle cell proliferation and differentiation
BR112012016027A2 (en) production method of polyetheretherketone antomicrobial implants
WO2011091420A3 (en) Osteogenic cell delivery matrix
AU2011328009A8 (en) Compounds and methods for treating pain
GB2535911A (en) Strigolactone formulations and uses thereof
NZ594887A (en) Use of synthetic and biological fungicides in combination for controlling harmful fungi
MX2014001219A (en) Sodium management for dialysis systems.
MY156275A (en) Compositions comprising tramadol and celecoxib in the treatment of pain
MX2016006708A (en) Synergistic bacterial compositions and methods of production and use thereof.
PH12012501440A1 (en) Device
WO2009017655A3 (en) Methods and compositions for stimulating the proliferation or differentiation of stem cells with substance p or an analog thereof
MX370853B (en) Formulations containing amorphous dapagliflozin.
WO2014028941A3 (en) Adipose composition systems and methods
MX2012012710A (en) Medical implants with increased hydrophilicity.
MX2009008471A (en) Process for treating substances contaminated by heavy metals.
WO2011084316A3 (en) Formulations and methods for controlling mdi particle size delivery
WO2014210037A3 (en) A composition of mesenchymal stem cells
MX360682B (en) A formulation comprising a particulate calcium silicate and clonostachys rosea for treating plants.
MY203648A (en) Preparations comprising amorphous emodepside
MX2009001724A (en) Breathable air safety system and method having an air storage sub-system.
WO2012104844A3 (en) Improved biocidal zeolites
WO2009134377A3 (en) Membrane biofilm reactor devices and systems for water treatment
MX2011012668A (en) Methods of administration of thrombopoietin agonist compounds.
MX2009004674A (en) Use of the ocp3 mutation to regulate drought resistance in plants.