IN2012DN03343A - - Google Patents

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Publication number
IN2012DN03343A
IN2012DN03343A IN3343DEN2012A IN2012DN03343A IN 2012DN03343 A IN2012DN03343 A IN 2012DN03343A IN 3343DEN2012 A IN3343DEN2012 A IN 3343DEN2012A IN 2012DN03343 A IN2012DN03343 A IN 2012DN03343A
Authority
IN
India
Prior art keywords
group
salt
present
benzazepine compound
perdeuteroalkyl
Prior art date
Application number
Inventor
Kan Keizo
Ohtani Tadaaki
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of IN2012DN03343A publication Critical patent/IN2012DN03343A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Studio Devices (AREA)

Abstract

An object of the present invention is to provide a novel benzazepine compound or a salt thereof, which has excellent vasopressin antagonistic activity. The benzazepine compound or a salt thereof of the present invention is represented by Formula (1): wherein R1, R2 and R5 may be the same or different and each represents H or D; and R3 and R4 each represents a C1-6 alkyl group, a C1-6 deuteroalkyl group, or a C1-6 perdeuteroalkyl group.
IN3343DEN2012 2009-10-26 2010-10-25 IN2012DN03343A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009245434 2009-10-26
PCT/JP2010/068807 WO2011052519A1 (en) 2009-10-26 2010-10-25 Benzazepine compound

Publications (1)

Publication Number Publication Date
IN2012DN03343A true IN2012DN03343A (en) 2015-10-23

Family

ID=43921941

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3343DEN2012 IN2012DN03343A (en) 2009-10-26 2010-10-25

Country Status (16)

Country Link
US (1) US8940727B2 (en)
EP (1) EP2495236A4 (en)
JP (1) JP5717645B2 (en)
KR (1) KR20120092139A (en)
CN (3) CN104447555A (en)
AU (1) AU2010312651A1 (en)
BR (1) BR112012009784A2 (en)
CA (1) CA2778756A1 (en)
CO (1) CO6481003A2 (en)
EA (1) EA022253B1 (en)
IL (1) IL219132A0 (en)
IN (1) IN2012DN03343A (en)
MX (1) MX2012004843A (en)
SG (1) SG10201406839VA (en)
WO (1) WO2011052519A1 (en)
ZA (1) ZA201202640B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3711B1 (en) 2015-07-13 2021-01-31 H Lundbeck As Antibodies specific for hyperphosphorylated tau and methods of use thereof
WO2019003433A1 (en) 2017-06-30 2019-01-03 大塚製薬株式会社 Benzazepine derivative
TW201938171A (en) 2017-12-15 2019-10-01 匈牙利商羅特格登公司 Tricyclic compounds as vasopressin V1a receptor antagonists
HU231206B1 (en) 2017-12-15 2021-10-28 Richter Gedeon Nyrt. Triazolobenzazepines
JP6868089B2 (en) * 2018-12-28 2021-05-12 大塚製薬株式会社 Medicine
CN112851583B (en) * 2021-01-19 2023-09-08 徐州医科大学 Novel benzazepine compounds, compositions and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5258510A (en) * 1989-10-20 1993-11-02 Otsuka Pharma Co Ltd Benzoheterocyclic compounds
ES2089033T3 (en) 1989-10-20 1996-10-01 Otsuka Pharma Co Ltd BENZOHETEROCICLICOS COMPOUNDS.
JP2905909B2 (en) * 1991-04-19 1999-06-14 大塚製薬株式会社 Vasopressin antagonist
US5753677A (en) * 1989-10-20 1998-05-19 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds
ATE277003T1 (en) 1993-07-21 2004-10-15 Yamanouchi Pharma Co Ltd INTERMEDIATE PRODUCT FOR PRODUCING CONDENSED BENZAZEPINE DERIVATIVES
ES2396365T3 (en) 2005-07-29 2013-02-21 Concert Pharmaceuticals Inc. New benzo [D] [1,3] -dioxol derivatives deuterated as serotonin reuptake inhibitors
EP2024365A4 (en) * 2006-06-05 2010-08-25 Auspex Pharmaceuticals Inc Preparation and utility of substituted imidazopyridine compounds with hypnotic effects
CN101687788A (en) * 2006-10-19 2010-03-31 奥斯拜客斯制药有限公司 The indoles that replaces
TWI459947B (en) * 2007-06-26 2014-11-11 Otsuka Pharma Co Ltd Benzazepine compound and pharmaceutical preparation
WO2009117144A1 (en) 2008-03-20 2009-09-24 Concert Pharmaceuticals, Inc. Benzazepine compounds

Also Published As

Publication number Publication date
JP5717645B2 (en) 2015-05-13
ZA201202640B (en) 2013-06-26
CA2778756A1 (en) 2011-05-05
CN104829531A (en) 2015-08-12
EP2495236A1 (en) 2012-09-05
EP2495236A4 (en) 2013-03-27
CO6481003A2 (en) 2012-07-16
AU2010312651A1 (en) 2012-05-03
CN102753530A (en) 2012-10-24
MX2012004843A (en) 2012-05-29
SG10201406839VA (en) 2014-12-30
BR112012009784A2 (en) 2016-05-17
WO2011052519A1 (en) 2011-05-05
EA201290228A1 (en) 2012-12-28
JPWO2011052519A1 (en) 2013-03-21
KR20120092139A (en) 2012-08-20
US20130131045A1 (en) 2013-05-23
CN102753530B (en) 2015-06-17
CN104447555A (en) 2015-03-25
US8940727B2 (en) 2015-01-27
IL219132A0 (en) 2012-06-28
EA022253B1 (en) 2015-11-30

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