IN2012DN03294A - - Google Patents
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- Publication number
- IN2012DN03294A IN2012DN03294A IN3294DEN2012A IN2012DN03294A IN 2012DN03294 A IN2012DN03294 A IN 2012DN03294A IN 3294DEN2012 A IN3294DEN2012 A IN 3294DEN2012A IN 2012DN03294 A IN2012DN03294 A IN 2012DN03294A
- Authority
- IN
- India
- Prior art keywords
- epitope
- candidate
- cross
- binding agent
- specific binding
- Prior art date
Links
- 239000011230 binding agent Substances 0.000 abstract 5
- 230000009870 specific binding Effects 0.000 abstract 5
- 241000710831 Flavivirus Species 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 230000027455 binding Effects 0.000 abstract 1
- 230000009918 complex formation Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24123—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24171—Demonstrated in vivo effect
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/18—Togaviridae; Flaviviridae
- G01N2333/183—Flaviviridae, e.g. pestivirus, mucosal disease virus, bovine viral diarrhoea virus, classical swine fever virus (hog cholera virus) or border disease virus
- G01N2333/185—Flaviviruses or Group B arboviruses, e.g. yellow fever virus, japanese encephalitis, tick-borne encephalitis, dengue
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
An in vitro method for identifying a flavivirus cross-reactive epitope, comprising selecting a candidate cross-reactive epitope using a structure-based design approach, wherein the structure-based design approach, designing a substituted epitope comprising at least one amino acid residue substitution compared to the candidate cross-reactive epitope; contacting the candidate cross-reactive epitope with a specific binding agent under conditions whereby a candidate epitope/specific binding agent complex can form; and contacting the substituted epitope with the specific binding agent under the same conditions used for candidate epitope/specific binding agent complex formation, wherein a candidate cross-reactive epitope is identified as the fiavivirus cross-reactive epitope when the substituted epitope has a substantially lower binding affinity for the specific binding agent compared to the candidate cross-reactive epitope.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59189804P | 2004-07-27 | 2004-07-27 | |
PCT/US2005/026672 WO2006025990A2 (en) | 2004-07-27 | 2005-07-27 | Localization and characterization of flavivirus envelope glycoprotein cross-reactive epitopes and methods for their use |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2012DN03294A true IN2012DN03294A (en) | 2015-10-23 |
Family
ID=36000491
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN3294DEN2012 IN2012DN03294A (en) | 2004-07-27 | 2005-07-27 |
Country Status (6)
Country | Link |
---|---|
US (3) | US7906292B2 (en) |
EP (1) | EP1784487B1 (en) |
AT (1) | ATE521627T1 (en) |
CA (1) | CA2576798C (en) |
IN (1) | IN2012DN03294A (en) |
WO (1) | WO2006025990A2 (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3150430A1 (en) | 2009-07-31 | 2011-02-03 | Pnuvax Inc. | High yield yellow fever virus strain with increased propagation in cells |
WO2013009884A1 (en) * | 2011-07-12 | 2013-01-17 | The Government Of The United States America As Represented By The Secretary Of The Department Of Health And Human Services | Identification of a west nile virus cd4 t cell epitope and use thereof |
WO2013059493A1 (en) * | 2011-10-20 | 2013-04-25 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | Dengue virus e-glycoprotein polypeptides containing mutations that eliminate immunodominant cross-reactive epitopes |
WO2014064943A1 (en) * | 2012-10-25 | 2014-05-01 | Osaka University | Antigenic peptide derived from dengue virus |
CN110734500A (en) | 2013-06-26 | 2020-01-31 | 北卡罗来纳-查佩尔山大学 | Methods and compositions for dengue virus vaccines |
US10060924B2 (en) | 2014-03-18 | 2018-08-28 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Distinguishing flavivirus infection using a recombinant mutant envelope protein |
WO2016130321A1 (en) * | 2015-02-09 | 2016-08-18 | Academia Sinica | An epitope-substituted vaccine for use in improving safety and immunogenicity against dengue viruses |
US11364292B2 (en) | 2015-07-21 | 2022-06-21 | Modernatx, Inc. | CHIKV RNA vaccines |
US11007260B2 (en) | 2015-07-21 | 2021-05-18 | Modernatx, Inc. | Infectious disease vaccines |
WO2017070624A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Tropical disease vaccines |
US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
GB201610162D0 (en) * | 2016-06-10 | 2016-07-27 | Imp Innovations Ltd And Inst Pasteur | Methods |
US10947277B2 (en) | 2016-06-13 | 2021-03-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Nucleic acids encoding zika virus-like particles and their use in zika virus vaccines and diagnostic assays |
WO2018052549A1 (en) | 2016-09-19 | 2018-03-22 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Zika virus vaccines |
EP3582790A4 (en) | 2017-02-16 | 2020-11-25 | ModernaTX, Inc. | High potency immunogenic compositions |
WO2018152526A1 (en) | 2017-02-20 | 2018-08-23 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Zika virus vaccines |
GB201704126D0 (en) * | 2017-03-15 | 2017-04-26 | Blom Nihlén Kim Andrea | Vaccine |
MA50253A (en) | 2017-09-14 | 2020-07-22 | Modernatx Inc | ZIKA VIRUS RNA VACCINES |
CN111048154B (en) * | 2019-12-10 | 2023-06-06 | 上海药明生物技术有限公司 | Method for mapping antibody epitope |
WO2022074111A1 (en) * | 2020-10-07 | 2022-04-14 | Sanofi Pasteur | Improved diagnostic tests |
WO2023178310A1 (en) * | 2022-03-17 | 2023-09-21 | The University Of North Carolina At Chapel Hill | Compositions comprising modified flavivirus e glycoproteins and methods of making and using the same |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK172110B1 (en) * | 1988-04-15 | 1997-10-27 | Gen Hospital Corp | Method for Isolating Mutants of DNA Sequences and Their Use in Identifying Cell Surface Proteins |
US6074865A (en) * | 1995-07-20 | 2000-06-13 | The United States Of America As Represented By The Secretary Of The Army | Recombinant dengue virus DNA fragment |
AU4556597A (en) | 1996-09-24 | 1998-04-17 | Bavarian Nordic Research Institute A/S | Recombinant mva virus expressing dengue virus antigens, and the use thereof in vaccines |
CU22683A1 (en) | 1997-01-15 | 2001-07-20 | Inst De Medicina Tropical Pedro Kouri | EPITHES OF THE PRE-M / M PROTEIN OF THE DENGUE VIRUS, SYNTHETIC PEPTIDES, CHEMICAL PROTEINS AND THEIR USES |
BRPI9701774B8 (en) | 1997-04-11 | 2015-09-29 | Fundação Oswaldo Cruz Fiocruz | mutant and infectious yellow fever virus cdna, DNA construct, recombinant yellow fever virus and human vaccine against yellow fever infections. |
AU778988B2 (en) | 1998-06-04 | 2004-12-23 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Nucleic acid vaccines for prevention of flavivirus infection |
US7227011B2 (en) | 1998-06-04 | 2007-06-05 | United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Nucleic acid vaccines for prevention of flavivirus infection |
CA2548808C (en) * | 2003-12-08 | 2015-07-07 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Monoclonal antibodies that bind or neutralize dengue virus |
-
2005
- 2005-07-27 CA CA2576798A patent/CA2576798C/en active Active
- 2005-07-27 WO PCT/US2005/026672 patent/WO2006025990A2/en active Application Filing
- 2005-07-27 US US11/572,805 patent/US7906292B2/en active Active
- 2005-07-27 AT AT05808971T patent/ATE521627T1/en not_active IP Right Cessation
- 2005-07-27 IN IN3294DEN2012 patent/IN2012DN03294A/en unknown
- 2005-07-27 EP EP05808971A patent/EP1784487B1/en active Active
-
2010
- 2010-09-28 US US12/892,714 patent/US9000141B2/en active Active
-
2015
- 2015-03-16 US US14/659,251 patent/US9650422B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20150246951A1 (en) | 2015-09-03 |
US9000141B2 (en) | 2015-04-07 |
EP1784487A2 (en) | 2007-05-16 |
ATE521627T1 (en) | 2011-09-15 |
US7906292B2 (en) | 2011-03-15 |
US20080248064A1 (en) | 2008-10-09 |
WO2006025990A3 (en) | 2006-06-29 |
US20110059131A1 (en) | 2011-03-10 |
US9650422B2 (en) | 2017-05-16 |
CA2576798C (en) | 2014-09-09 |
EP1784487B1 (en) | 2011-08-24 |
CA2576798A1 (en) | 2006-03-09 |
WO2006025990A2 (en) | 2006-03-09 |
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