IN2012DN02487A - - Google Patents
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- Publication number
- IN2012DN02487A IN2012DN02487A IN2487DEN2012A IN2012DN02487A IN 2012DN02487 A IN2012DN02487 A IN 2012DN02487A IN 2487DEN2012 A IN2487DEN2012 A IN 2487DEN2012A IN 2012DN02487 A IN2012DN02487 A IN 2012DN02487A
- Authority
- IN
- India
- Prior art keywords
- enantiomers
- esters
- useful
- formula
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
There are provided compounds of the formula wherein X, Y, R1, R2, R3, R3, R4, and R5 are as described herein and enantiomers and pharmaceutically acceptable salts and esters thereof which are useful as anticancer agents.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25141309P | 2009-10-14 | 2009-10-14 | |
US34562610P | 2010-05-18 | 2010-05-18 | |
PCT/EP2010/065159 WO2011045257A1 (en) | 2009-10-14 | 2010-10-11 | Novel n-substituted-pyrrolidines as inhibitors of mdm2-p-53 interactions |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2012DN02487A true IN2012DN02487A (en) | 2015-08-28 |
Family
ID=43567698
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN2487DEN2012 IN2012DN02487A (en) | 2009-10-14 | 2010-10-11 |
Country Status (12)
Country | Link |
---|---|
US (1) | US8017607B2 (en) |
EP (1) | EP2488491A1 (en) |
JP (1) | JP2013507416A (en) |
KR (1) | KR20120081210A (en) |
CN (1) | CN102548963A (en) |
AU (1) | AU2010305914A1 (en) |
BR (1) | BR112012008485A2 (en) |
CA (1) | CA2774512A1 (en) |
IL (1) | IL218018A0 (en) |
IN (1) | IN2012DN02487A (en) |
MX (1) | MX2012003982A (en) |
WO (1) | WO2011045257A1 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2008210434C8 (en) | 2007-01-31 | 2014-03-27 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
BRPI0809366B8 (en) | 2007-03-28 | 2021-05-25 | Harvard College | substantially alpha-helical polypeptide, method for manufacturing same, amino acid and pharmaceutical composition |
US8354444B2 (en) * | 2008-09-18 | 2013-01-15 | Hoffmann-La Roche Inc. | Substituted pyrrolidine-2-carboxamides |
US20110118283A1 (en) * | 2009-11-17 | 2011-05-19 | Qingjie Ding | Substituted Pyrrolidine-2-Carboxamides |
US8859723B2 (en) | 2010-08-13 | 2014-10-14 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
WO2012076513A1 (en) * | 2010-12-09 | 2012-06-14 | F. Hoffmann-La Roche Ag | 3-cyano-1-hydroxymethyl-2-phenylpyrrolidine derivatives as inhibitors of mdm2-p53 interactions useful for the treatment of cancer |
SG193002A1 (en) | 2011-03-10 | 2013-09-30 | Daiichi Sankyo Co Ltd | Dispiropyrrolidine derivative |
CN108929375A (en) | 2011-10-18 | 2018-12-04 | 爱勒让治疗公司 | Peptidomimetic macrocyclic compound |
US8987414B2 (en) | 2012-02-15 | 2015-03-24 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
US8927500B2 (en) | 2012-02-15 | 2015-01-06 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
TWI586668B (en) | 2012-09-06 | 2017-06-11 | 第一三共股份有限公司 | Crystals of dispiropyrrolidine derivative |
JP6526563B2 (en) | 2012-11-01 | 2019-06-05 | エイルロン セラピューティクス,インコーポレイテッド | Disubstituted amino acids and methods for their preparation and use |
RU2690663C2 (en) | 2012-12-20 | 2019-06-05 | Мерк Шарп И Доум Корп. | Substituted imidazopyridines as hdm2 inhibitors |
US10905739B2 (en) | 2014-09-24 | 2021-02-02 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and formulations thereof |
SG10201902594QA (en) | 2014-09-24 | 2019-04-29 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
MX2017011834A (en) | 2015-03-20 | 2018-04-11 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof. |
EP3347372A4 (en) | 2015-09-10 | 2019-09-04 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles as modulators of mcl-1 |
WO2017201449A1 (en) | 2016-05-20 | 2017-11-23 | Genentech, Inc. | Protac antibody conjugates and methods of use |
WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0947511A1 (en) | 1998-03-30 | 1999-10-06 | F. Hoffmann-La Roche Ag | Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity |
RU2002104496A (en) | 1999-07-21 | 2003-09-27 | Астразенека Аб (Se) | NEW COMPOUNDS |
WO2005099687A2 (en) | 2004-04-09 | 2005-10-27 | President And Fellows Of Harvard College | Analogs of salinosporamide a |
US7423051B2 (en) | 2004-07-15 | 2008-09-09 | Hoffmann-La Roche Inc. | 2,6-diaminopyridine derivatives |
CA2598690C (en) | 2005-02-22 | 2011-11-15 | The Regents Of The University Of Michigan | Small molecule inhibitors of mdm2 and uses thereof |
EP1979338A1 (en) | 2006-01-18 | 2008-10-15 | F.Hoffmann-La Roche Ag | Cis-4, 5-biaryl-2-heterocyclic-imidazolines as mdm2 inhibitors |
CA2656398A1 (en) | 2006-06-30 | 2008-01-10 | Schering Corporation | Substituted piperidines that increase p53 activity and the uses thereof |
PE20110367A1 (en) | 2008-09-18 | 2011-06-13 | Hoffmann La Roche | DERIVATIVES OF 4-CYANO-4-PHENYL-PYRROLIDIN-2-CARBOXAMIDES SUBSTITUTED AS INHIBITORS OF THE INTERACTION p53-MDM2 |
-
2010
- 2010-10-06 US US12/898,974 patent/US8017607B2/en not_active Expired - Fee Related
- 2010-10-11 WO PCT/EP2010/065159 patent/WO2011045257A1/en active Application Filing
- 2010-10-11 IN IN2487DEN2012 patent/IN2012DN02487A/en unknown
- 2010-10-11 BR BR112012008485A patent/BR112012008485A2/en not_active IP Right Cessation
- 2010-10-11 JP JP2012533592A patent/JP2013507416A/en active Pending
- 2010-10-11 EP EP10768450A patent/EP2488491A1/en not_active Withdrawn
- 2010-10-11 KR KR1020127012100A patent/KR20120081210A/en not_active Application Discontinuation
- 2010-10-11 CN CN2010800461741A patent/CN102548963A/en active Pending
- 2010-10-11 MX MX2012003982A patent/MX2012003982A/en not_active Application Discontinuation
- 2010-10-11 CA CA2774512A patent/CA2774512A1/en not_active Abandoned
- 2010-10-11 AU AU2010305914A patent/AU2010305914A1/en not_active Abandoned
-
2012
- 2012-02-09 IL IL218018A patent/IL218018A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20120081210A (en) | 2012-07-18 |
AU2010305914A1 (en) | 2012-03-08 |
WO2011045257A1 (en) | 2011-04-21 |
CN102548963A (en) | 2012-07-04 |
MX2012003982A (en) | 2012-05-08 |
JP2013507416A (en) | 2013-03-04 |
EP2488491A1 (en) | 2012-08-22 |
US20110086854A1 (en) | 2011-04-14 |
CA2774512A1 (en) | 2011-04-21 |
BR112012008485A2 (en) | 2019-09-24 |
IL218018A0 (en) | 2012-04-30 |
US8017607B2 (en) | 2011-09-13 |
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