IN2012DN02126A - - Google Patents

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Publication number
IN2012DN02126A
IN2012DN02126A IN2126DEN2012A IN2012DN02126A IN 2012DN02126 A IN2012DN02126 A IN 2012DN02126A IN 2126DEN2012 A IN2126DEN2012 A IN 2126DEN2012A IN 2012DN02126 A IN2012DN02126 A IN 2012DN02126A
Authority
IN
India
Prior art keywords
compound
diagnostic
composition
pharmaceutically acceptable
acceptable carrier
Prior art date
Application number
Inventor
Wistrand Lars-Goran
Thaning Mikkel
Newton Ben
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of IN2012DN02126A publication Critical patent/IN2012DN02126A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0452Solutions, e.g. for injection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol

Abstract

The present invention relates to a new diagnostic X-ray composition which exhibits a superior cardiac safety profile. The composition comprises a non-ionic iodinated dimer in a pharmaceutically acceptable carrier. More particularly, the invention provides a diagnostic composition comprising a Compound I, Compound I a pharmaceutically acceptable carrier, and dissolved therein a sodium compound and a calcium compound providing a sodium ion concentration of 40-50 mM and a calcium ion concentration of 0.1-0.7 mM. The invention also relates to methods of imaging using such diagnostic compositions.
IN2126DEN2012 2009-10-29 2010-10-28 IN2012DN02126A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09174413 2009-10-29
PCT/EP2010/066351 WO2011051387A1 (en) 2009-10-29 2010-10-28 Diagnostic composition comprising plasma cations having superior safety profile

Publications (1)

Publication Number Publication Date
IN2012DN02126A true IN2012DN02126A (en) 2015-08-21

Family

ID=43503035

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2126DEN2012 IN2012DN02126A (en) 2009-10-29 2010-10-28

Country Status (21)

Country Link
US (1) US8815210B2 (en)
EP (1) EP2493511B1 (en)
JP (1) JP5335147B2 (en)
KR (1) KR101545045B1 (en)
CN (1) CN102596257B (en)
AU (1) AU2010311478B2 (en)
BR (1) BR112012009859B1 (en)
CA (1) CA2773685C (en)
CO (1) CO6531477A2 (en)
DK (1) DK2493511T3 (en)
ES (1) ES2435299T3 (en)
HR (1) HRP20130991T1 (en)
IL (1) IL218456A (en)
IN (1) IN2012DN02126A (en)
MX (1) MX2012005021A (en)
NZ (1) NZ598540A (en)
PL (1) PL2493511T3 (en)
PT (1) PT2493511E (en)
RU (1) RU2544113C2 (en)
WO (1) WO2011051387A1 (en)
ZA (1) ZA201203505B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO333914B1 (en) * 2011-12-21 2013-10-21 Ge Healthcare As Stabilization of diagnostic X-ray composition
AU2013208955B2 (en) * 2012-01-11 2017-11-16 Ge Healthcare As X-ray imaging contrast media with low iodine concentration and X-ray imaging process
EP2978454A1 (en) * 2013-03-27 2016-02-03 Ge Healthcare As Method and reagent for preparing a diagnostic composition
US10575744B2 (en) 2017-02-24 2020-03-03 Medtronic Cryocath Lp Pericardial balloon mapping
CN109876157B (en) * 2019-02-27 2020-12-15 浙江大学 Composite material of ion-specific filter membrane/mesoporous silicon, nano sensor, product of nano sensor and application of nano sensor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59104352A (en) * 1982-11-08 1984-06-16 ニユエガ−ド・アンド・コンパニ−・アクシエ・セルカペト X ray contrast agent
GB8906130D0 (en) * 1989-03-17 1989-05-04 Nycomed As Compositions
GB9020091D0 (en) 1990-09-14 1990-10-24 Nycomed As Contrast media
DE4344464A1 (en) * 1993-12-22 1995-06-29 Schering Ag Cascade polymers with iodine aromatics
GB9419203D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
US8066970B2 (en) * 2006-05-11 2011-11-29 Ge Healthcare As Contrast agents
EP2178568B1 (en) 2007-07-12 2014-07-02 Ge Healthcare As Contrast agents

Also Published As

Publication number Publication date
US20120328522A1 (en) 2012-12-27
EP2493511B1 (en) 2013-10-16
BR112012009859A2 (en) 2016-08-30
AU2010311478A1 (en) 2012-03-29
PT2493511E (en) 2013-11-18
CO6531477A2 (en) 2012-09-28
BR112012009859B1 (en) 2019-10-22
NZ598540A (en) 2014-03-28
MX2012005021A (en) 2012-06-19
CA2773685C (en) 2016-05-31
RU2544113C2 (en) 2015-03-10
HRP20130991T1 (en) 2013-12-20
JP2013509378A (en) 2013-03-14
US8815210B2 (en) 2014-08-26
IL218456A (en) 2015-08-31
CA2773685A1 (en) 2011-05-05
WO2011051387A1 (en) 2011-05-05
KR20120091149A (en) 2012-08-17
PL2493511T3 (en) 2014-05-30
ES2435299T3 (en) 2013-12-18
CN102596257A (en) 2012-07-18
ZA201203505B (en) 2013-01-31
KR101545045B1 (en) 2015-08-17
DK2493511T3 (en) 2013-11-25
AU2010311478B2 (en) 2015-09-24
EP2493511A1 (en) 2012-09-05
RU2012116882A (en) 2013-12-10
CN102596257B (en) 2013-08-21
IL218456A0 (en) 2012-04-30
JP5335147B2 (en) 2013-11-06

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