IN2012DN02126A - - Google Patents
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- Publication number
- IN2012DN02126A IN2012DN02126A IN2126DEN2012A IN2012DN02126A IN 2012DN02126 A IN2012DN02126 A IN 2012DN02126A IN 2126DEN2012 A IN2126DEN2012 A IN 2126DEN2012A IN 2012DN02126 A IN2012DN02126 A IN 2012DN02126A
- Authority
- IN
- India
- Prior art keywords
- compound
- diagnostic
- composition
- pharmaceutically acceptable
- acceptable carrier
- Prior art date
Links
- 239000000203 mixture Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003937 drug carrier Substances 0.000 abstract 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 abstract 1
- 229940043430 calcium compound Drugs 0.000 abstract 1
- 150000001674 calcium compounds Chemical class 0.000 abstract 1
- 229910001424 calcium ion Inorganic materials 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 239000000539 dimer Substances 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003388 sodium compounds Chemical class 0.000 abstract 1
- 229910001415 sodium ion Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0452—Solutions, e.g. for injection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The present invention relates to a new diagnostic X-ray composition which exhibits a superior cardiac safety profile. The composition comprises a non-ionic iodinated dimer in a pharmaceutically acceptable carrier. More particularly, the invention provides a diagnostic composition comprising a Compound I, Compound I a pharmaceutically acceptable carrier, and dissolved therein a sodium compound and a calcium compound providing a sodium ion concentration of 40-50 mM and a calcium ion concentration of 0.1-0.7 mM. The invention also relates to methods of imaging using such diagnostic compositions.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09174413 | 2009-10-29 | ||
| PCT/EP2010/066351 WO2011051387A1 (en) | 2009-10-29 | 2010-10-28 | Diagnostic composition comprising plasma cations having superior safety profile |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN02126A true IN2012DN02126A (en) | 2015-08-21 |
Family
ID=43503035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2126DEN2012 IN2012DN02126A (en) | 2009-10-29 | 2010-10-28 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8815210B2 (en) |
| EP (1) | EP2493511B1 (en) |
| JP (1) | JP5335147B2 (en) |
| KR (1) | KR101545045B1 (en) |
| CN (1) | CN102596257B (en) |
| AU (1) | AU2010311478B2 (en) |
| BR (1) | BR112012009859B1 (en) |
| CA (1) | CA2773685C (en) |
| CO (1) | CO6531477A2 (en) |
| DK (1) | DK2493511T3 (en) |
| ES (1) | ES2435299T3 (en) |
| HR (1) | HRP20130991T1 (en) |
| IL (1) | IL218456A (en) |
| IN (1) | IN2012DN02126A (en) |
| MX (1) | MX2012005021A (en) |
| NZ (1) | NZ598540A (en) |
| PL (1) | PL2493511T3 (en) |
| PT (1) | PT2493511E (en) |
| RU (1) | RU2544113C2 (en) |
| WO (1) | WO2011051387A1 (en) |
| ZA (1) | ZA201203505B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO333914B1 (en) * | 2011-12-21 | 2013-10-21 | Ge Healthcare As | Stabilization of diagnostic X-ray composition |
| CA2862495A1 (en) * | 2012-01-11 | 2013-07-18 | Ge Healthcare As | X-ray imaging contrast media with low iodine concentration and x-ray imaging process |
| BR112015024564A2 (en) * | 2013-03-27 | 2017-07-18 | Ge Healthcare As | aqueous excipient solution, kit, and methods for diluting a diagnostic composition to produce an aqueous excipient solution, and for diagnostic and image detection |
| US10575744B2 (en) | 2017-02-24 | 2020-03-03 | Medtronic Cryocath Lp | Pericardial balloon mapping |
| CN109876157B (en) * | 2019-02-27 | 2020-12-15 | 浙江大学 | Ion-specific membrane/mesoporous silicon composites, nanosensors and their products and applications |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO161368C (en) * | 1982-11-08 | 1989-08-09 | Nyegaard & Co As | ROENTGEN CONTRACTORS AND RADIOLOGICAL PREPARATIONS THEREOF. |
| GB8906130D0 (en) | 1989-03-17 | 1989-05-04 | Nycomed As | Compositions |
| GB9020091D0 (en) | 1990-09-14 | 1990-10-24 | Nycomed As | Contrast media |
| DE4344464A1 (en) * | 1993-12-22 | 1995-06-29 | Schering Ag | Cascade polymers with iodine aromatics |
| GB9419203D0 (en) * | 1994-09-23 | 1994-11-09 | Nycomed Innovation Ab | Contrast media |
| US8066970B2 (en) * | 2006-05-11 | 2011-11-29 | Ge Healthcare As | Contrast agents |
| BRPI0814811A2 (en) * | 2007-07-12 | 2015-02-03 | Ge Healthcare As | COMPOUND, AGENT, METHOD, AND DIAGNOSTIC COMPOSITION, USE OF A COMPOUND, AND IMAGE FORMATION METHOD |
-
2010
- 2010-10-28 EP EP10771120.2A patent/EP2493511B1/en not_active Not-in-force
- 2010-10-28 WO PCT/EP2010/066351 patent/WO2011051387A1/en active Application Filing
- 2010-10-28 IN IN2126DEN2012 patent/IN2012DN02126A/en unknown
- 2010-10-28 NZ NZ598540A patent/NZ598540A/en not_active IP Right Cessation
- 2010-10-28 AU AU2010311478A patent/AU2010311478B2/en not_active Ceased
- 2010-10-28 JP JP2012535827A patent/JP5335147B2/en not_active Expired - Fee Related
- 2010-10-28 DK DK10771120.2T patent/DK2493511T3/en active
- 2010-10-28 PL PL10771120T patent/PL2493511T3/en unknown
- 2010-10-28 HR HRP20130991AT patent/HRP20130991T1/en unknown
- 2010-10-28 PT PT107711202T patent/PT2493511E/en unknown
- 2010-10-28 CN CN2010800498286A patent/CN102596257B/en not_active Expired - Fee Related
- 2010-10-28 BR BR112012009859A patent/BR112012009859B1/en not_active IP Right Cessation
- 2010-10-28 CA CA2773685A patent/CA2773685C/en not_active Expired - Fee Related
- 2010-10-28 RU RU2012116882/15A patent/RU2544113C2/en not_active IP Right Cessation
- 2010-10-28 US US13/497,641 patent/US8815210B2/en not_active Expired - Fee Related
- 2010-10-28 ES ES10771120T patent/ES2435299T3/en active Active
- 2010-10-28 KR KR1020127010930A patent/KR101545045B1/en not_active Expired - Fee Related
- 2010-10-28 MX MX2012005021A patent/MX2012005021A/en active IP Right Grant
-
2012
- 2012-03-04 IL IL218456A patent/IL218456A/en not_active IP Right Cessation
- 2012-04-25 CO CO12068011A patent/CO6531477A2/en unknown
- 2012-05-14 ZA ZA2012/03505A patent/ZA201203505B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011051387A1 (en) | 2011-05-05 |
| PL2493511T3 (en) | 2014-05-30 |
| BR112012009859B1 (en) | 2019-10-22 |
| RU2012116882A (en) | 2013-12-10 |
| AU2010311478A1 (en) | 2012-03-29 |
| CA2773685A1 (en) | 2011-05-05 |
| CN102596257B (en) | 2013-08-21 |
| DK2493511T3 (en) | 2013-11-25 |
| JP2013509378A (en) | 2013-03-14 |
| US20120328522A1 (en) | 2012-12-27 |
| KR20120091149A (en) | 2012-08-17 |
| HRP20130991T1 (en) | 2013-12-20 |
| MX2012005021A (en) | 2012-06-19 |
| CN102596257A (en) | 2012-07-18 |
| PT2493511E (en) | 2013-11-18 |
| ES2435299T3 (en) | 2013-12-18 |
| EP2493511B1 (en) | 2013-10-16 |
| NZ598540A (en) | 2014-03-28 |
| AU2010311478B2 (en) | 2015-09-24 |
| EP2493511A1 (en) | 2012-09-05 |
| CA2773685C (en) | 2016-05-31 |
| US8815210B2 (en) | 2014-08-26 |
| IL218456A (en) | 2015-08-31 |
| IL218456A0 (en) | 2012-04-30 |
| CO6531477A2 (en) | 2012-09-28 |
| BR112012009859A2 (en) | 2016-08-30 |
| RU2544113C2 (en) | 2015-03-10 |
| JP5335147B2 (en) | 2013-11-06 |
| ZA201203505B (en) | 2013-01-31 |
| KR101545045B1 (en) | 2015-08-17 |
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