IN2012DN02069A - - Google Patents
Download PDFInfo
- Publication number
- IN2012DN02069A IN2012DN02069A IN2069DEN2012A IN2012DN02069A IN 2012DN02069 A IN2012DN02069 A IN 2012DN02069A IN 2069DEN2012 A IN2069DEN2012 A IN 2069DEN2012A IN 2012DN02069 A IN2012DN02069 A IN 2012DN02069A
- Authority
- IN
- India
- Prior art keywords
- present
- smo
- compound
- prodrug
- prophylaxis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
The present invention provides a fused heterocycle derivative having a strong Smo inhibitory activity, and use thereof. Specially, the present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or salt thereof, and a medicament containing the compound or a prodrug thereof, which is an Smo inhibitor or an agent for the prophylaxis or treatment of cancer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009195770 | 2009-08-26 | ||
JP2010015644 | 2010-01-27 | ||
PCT/JP2010/064413 WO2011024872A1 (en) | 2009-08-26 | 2010-08-25 | Fused heterocyclic ring derivative and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2012DN02069A true IN2012DN02069A (en) | 2015-08-21 |
Family
ID=43627972
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN2069DEN2012 IN2012DN02069A (en) | 2009-08-26 | 2010-08-25 |
Country Status (24)
Country | Link |
---|---|
US (1) | US8907089B2 (en) |
EP (1) | EP2471790B1 (en) |
JP (1) | JP5599802B2 (en) |
KR (1) | KR20120078703A (en) |
CN (1) | CN102574851A (en) |
AU (1) | AU2010287492A1 (en) |
BR (1) | BR112012004134A2 (en) |
CA (1) | CA2771833A1 (en) |
CL (1) | CL2012000461A1 (en) |
CR (1) | CR20120095A (en) |
DO (1) | DOP2012000048A (en) |
EA (1) | EA201270311A1 (en) |
EC (1) | ECSP12011747A (en) |
GE (1) | GEP20146075B (en) |
IL (1) | IL218323A0 (en) |
IN (1) | IN2012DN02069A (en) |
MA (1) | MA33589B1 (en) |
MX (1) | MX2012002419A (en) |
NZ (1) | NZ598749A (en) |
PE (1) | PE20121326A1 (en) |
SG (1) | SG178504A1 (en) |
TN (1) | TN2012000084A1 (en) |
WO (1) | WO2011024872A1 (en) |
ZA (1) | ZA201201795B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011024871A1 (en) * | 2009-08-26 | 2011-03-03 | 武田薬品工業株式会社 | Fused heterocyclic ring derivative and use thereof |
KR20150128842A (en) | 2013-03-14 | 2015-11-18 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | Furopyridines as bromodomain inhibitors |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6436965B1 (en) | 2000-03-02 | 2002-08-20 | Merck Frosst Canada & Co. | PDE IV inhibiting amides, compositions and methods of treatment |
WO2002012189A1 (en) | 2000-08-09 | 2002-02-14 | Mitsubishi Pharma Corporation | Fused bicyclic amide compounds and medicinal use thereof |
AU2002351412B2 (en) | 2001-12-21 | 2010-05-20 | Exelixis Patent Company Llc | Modulators of LXR |
US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
WO2004020599A2 (en) | 2002-08-29 | 2004-03-11 | Curis, Inc. | Hedgehog antagonists, methods and uses related thereto |
US8067608B2 (en) | 2003-09-29 | 2011-11-29 | The Johns Hopkins University | Hedgehog pathway antagonists |
US20050203081A1 (en) | 2004-02-25 | 2005-09-15 | Jinbo Lee | Inhibitors of protein tyrosine phosphatase 1B |
GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
US20080194637A1 (en) | 2006-11-02 | 2008-08-14 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
WO2008057468A1 (en) | 2006-11-02 | 2008-05-15 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
WO2009004427A2 (en) | 2007-06-29 | 2009-01-08 | Pfizer Inc. | Benzimidazole derivatives |
RU2364597C1 (en) | 2007-12-14 | 2009-08-20 | Андрей Александрович Иващенко | HETEROCYCLIC INHIBITORS OF Hh-SYGNAL CASCADE, BASED ON THEM MEDICINAL COMPOSITIONS AND METHOD OF TREATING DISEASES INDUCED BY ABBARANT ACTIVITY OF Hh-SIGNAL SYSTEM |
JP4685891B2 (en) | 2008-02-19 | 2011-05-18 | 株式会社ハネックス | Separation device |
AR070479A1 (en) | 2008-02-26 | 2010-04-07 | Takeda Pharmaceutical | FUSIONED HETEROCICLIC DERIVATIVE AND ITS USE |
JP2010015644A (en) | 2008-07-04 | 2010-01-21 | Fujitsu Ltd | Spindle system, electromagnetic conversion property evaluating apparatus and information storage device |
GB0900484D0 (en) | 2009-01-13 | 2009-02-11 | Angeletti P Ist Richerche Bio | Therapeutic agent |
-
2010
- 2010-08-25 CN CN2010800469387A patent/CN102574851A/en active Pending
- 2010-08-25 KR KR1020127007793A patent/KR20120078703A/en not_active Application Discontinuation
- 2010-08-25 AU AU2010287492A patent/AU2010287492A1/en not_active Abandoned
- 2010-08-25 PE PE2012000255A patent/PE20121326A1/en not_active Application Discontinuation
- 2010-08-25 MX MX2012002419A patent/MX2012002419A/en not_active Application Discontinuation
- 2010-08-25 JP JP2011528831A patent/JP5599802B2/en active Active
- 2010-08-25 SG SG2012011599A patent/SG178504A1/en unknown
- 2010-08-25 BR BR112012004134A patent/BR112012004134A2/en not_active IP Right Cessation
- 2010-08-25 US US13/391,791 patent/US8907089B2/en active Active
- 2010-08-25 CA CA2771833A patent/CA2771833A1/en not_active Abandoned
- 2010-08-25 WO PCT/JP2010/064413 patent/WO2011024872A1/en active Application Filing
- 2010-08-25 EA EA201270311A patent/EA201270311A1/en unknown
- 2010-08-25 GE GEAP201012641A patent/GEP20146075B/en unknown
- 2010-08-25 IN IN2069DEN2012 patent/IN2012DN02069A/en unknown
- 2010-08-25 NZ NZ598749A patent/NZ598749A/en not_active IP Right Cessation
- 2010-08-25 EP EP10811921.5A patent/EP2471790B1/en active Active
-
2012
- 2012-02-21 TN TNP2012000084A patent/TN2012000084A1/en unknown
- 2012-02-22 DO DO2012000048A patent/DOP2012000048A/en unknown
- 2012-02-23 CL CL2012000461A patent/CL2012000461A1/en unknown
- 2012-02-24 CR CR20120095A patent/CR20120095A/en not_active Application Discontinuation
- 2012-02-26 IL IL218323A patent/IL218323A0/en unknown
- 2012-03-12 ZA ZA2012/01795A patent/ZA201201795B/en unknown
- 2012-03-16 MA MA34695A patent/MA33589B1/en unknown
- 2012-03-26 EC ECSP12011747 patent/ECSP12011747A/en unknown
Also Published As
Publication number | Publication date |
---|---|
JPWO2011024872A1 (en) | 2013-01-31 |
ZA201201795B (en) | 2013-05-29 |
GEP20146075B (en) | 2014-04-10 |
CN102574851A (en) | 2012-07-11 |
MA33589B1 (en) | 2012-09-01 |
MX2012002419A (en) | 2012-04-19 |
EP2471790B1 (en) | 2015-03-18 |
AU2010287492A1 (en) | 2012-03-29 |
ECSP12011747A (en) | 2012-05-30 |
DOP2012000048A (en) | 2012-05-15 |
NZ598749A (en) | 2013-01-25 |
CR20120095A (en) | 2012-06-26 |
KR20120078703A (en) | 2012-07-10 |
US8907089B2 (en) | 2014-12-09 |
CA2771833A1 (en) | 2011-03-03 |
PE20121326A1 (en) | 2012-10-11 |
EP2471790A1 (en) | 2012-07-04 |
IL218323A0 (en) | 2012-04-30 |
CL2012000461A1 (en) | 2012-10-05 |
WO2011024872A1 (en) | 2011-03-03 |
EA201270311A1 (en) | 2012-09-28 |
SG178504A1 (en) | 2012-04-27 |
EP2471790A4 (en) | 2013-07-31 |
BR112012004134A2 (en) | 2017-06-20 |
TN2012000084A1 (en) | 2013-09-19 |
JP5599802B2 (en) | 2014-10-01 |
US20120220570A1 (en) | 2012-08-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TN2012000401A1 (en) | Heterocyclic compound | |
PH12016502382A1 (en) | Substituted indazole compounds as irak4 inhibitors | |
MY185103A (en) | Bezylamine derivatives as inhibitors of plasma kallikrein | |
GEP201606532B (en) | Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1 | |
TN2014000122A1 (en) | 1 - arylcarbonyl - 4 - oxy - piperidine compounds useful for the treatment of neurodegenerative diseases | |
MD20160106A2 (en) | Bicyclic-fused heteroaryl or aryl compounds and their use as IRAK4 inhibitors | |
MY172924A (en) | Neprilysin inhibitors | |
TN2014000128A1 (en) | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh | |
MX2011011854A (en) | Dihydropyrimidinones for use as bace2 inhibitors. | |
MD20150043A2 (en) | Inhibitors of histone demethylases | |
UA111382C2 (en) | Protein kinase inhibitors | |
MX352672B (en) | Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer. | |
SG190819A1 (en) | Nampt and rock inhibitors | |
MX2011009796A (en) | Inhibitors of pi3 kinase. | |
PH12014502396B1 (en) | Nitrogenated heterocyclic compound | |
AU2012214029A8 (en) | Rorgammat inhibitors | |
MX2013006113A (en) | Bicyclic compound. | |
MX2010008460A (en) | Thiazole derivative and use thereof as vap-1 inhibitor. | |
IN2014CN04558A (en) | ||
PH12016502130B1 (en) | Novel pyrrolopyrimidine compound or salt thereof, pharmaceutical composition containing same, especially agent for prevention and/or treatment of tumors etc based on nae inhibitory effect | |
NZ700356A (en) | Pyrazole compounds as sglt1 inhibitors | |
MX2014013758A (en) | Thiazolecarboxamide derivatives for use as nampt inhibitors. | |
MX2013002511A (en) | Fused triazoles for the treatment or prophylaxis of mild cognitive impairment. | |
EP2602254A4 (en) | Heterocyclic compound | |
GEP20156244B (en) | New tertiary 8-hydroxyquinoline-7- carboxamide derivatives and usage thereof |