IN2012DN01945A - - Google Patents

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Publication number
IN2012DN01945A
IN2012DN01945A IN1945DEN2012A IN2012DN01945A IN 2012DN01945 A IN2012DN01945 A IN 2012DN01945A IN 1945DEN2012 A IN1945DEN2012 A IN 1945DEN2012A IN 2012DN01945 A IN2012DN01945 A IN 2012DN01945A
Authority
IN
India
Prior art keywords
property value
mixing
liquid flow
stock solution
stock solutions
Prior art date
Application number
Inventor
Blank Torbjorn
Carredano Enrique
Ekstrom Karl
Lynga Jan-Erik
Nordberg Roger
Peters Mike
Rodrigo Gustav
Sandegren Henrik
Stack Lisa
Original Assignee
Ge Healthcare Bio Sciences Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Bio Sciences Ab filed Critical Ge Healthcare Bio Sciences Ab
Publication of IN2012DN01945A publication Critical patent/IN2012DN01945A/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
    • B01D15/166—Fluid composition conditioning, e.g. gradient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/21—Measuring
    • B01F35/2132—Concentration, pH, pOH, p(ION) or oxygen-demand
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/21—Measuring
    • B01F35/2133—Electrical conductivity or dielectric constant of the mixture
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D11/00—Control of flow ratio
    • G05D11/02—Controlling ratio of two or more flows of fluid or fluent material
    • G05D11/13—Controlling ratio of two or more flows of fluid or fluent material characterised by the use of electric means
    • G05D11/131—Controlling ratio of two or more flows of fluid or fluent material characterised by the use of electric means by measuring the values related to the quantity of the individual components
    • G05D11/132—Controlling ratio of two or more flows of fluid or fluent material characterised by the use of electric means by measuring the values related to the quantity of the individual components by controlling the flow of the individual components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • G01N2030/347—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient mixers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Automation & Control Theory (AREA)
  • Health & Medical Sciences (AREA)
  • Accessories For Mixers (AREA)

Abstract

A method for preparing a liquid flow having pre-defined characteristics by mixing liquid flows of at least two different component stock solutions with each other comprises the steps of determining a selected property value for one or more of the stock solutions by sensing, in a flow of each stock solution separately, at least one characteristic related to the property value for the stock solution, and based on the determined property value or values, mixing the stock solution flows in mixing ratios giving the desired mixed liquid flow. A system for carrying out the method comprises sensor means and a control unit, wherein the control unit is arranged to evaluate the characteristics sensed by the sensor means and provide relative ratios of stock solutions required to obtain a mixed liquid flow having the pre-defined characteristics.
IN1945DEN2012 2009-09-25 2010-09-23 IN2012DN01945A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0950703 2009-09-25
PCT/SE2010/051023 WO2011037530A1 (en) 2009-09-25 2010-09-23 Method and system for preparation of liquid mixtures

Publications (1)

Publication Number Publication Date
IN2012DN01945A true IN2012DN01945A (en) 2015-08-21

Family

ID=43796083

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1945DEN2012 IN2012DN01945A (en) 2009-09-25 2010-09-23

Country Status (7)

Country Link
US (1) US9327212B2 (en)
EP (1) EP2480943B1 (en)
JP (1) JP5961112B2 (en)
CN (2) CN107983261A (en)
AU (1) AU2010298776A1 (en)
IN (1) IN2012DN01945A (en)
WO (1) WO2011037530A1 (en)

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CN107003288B (en) * 2014-12-12 2020-07-28 通用电气健康护理生物科学股份公司 System for preparing solution for chromatography
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WO2016134279A1 (en) * 2015-02-19 2016-08-25 Asahi Kasei Bioprocess, Inc. System and method for compensating binary inlet buffers during inline buffer diluation
CN110325852B (en) * 2016-08-31 2021-10-26 株式会社岛津制作所 Control device and method for liquid chromatography device, and liquid chromatography system
US10260918B2 (en) * 2017-04-21 2019-04-16 Pixart Imaging Inc. Flow amount measuring apparatus, material mixing system and non transitory computer readable medium performing material mixing method
DE102017109127A1 (en) * 2017-04-27 2018-10-31 B. Braun Avitum Ag Method and device for the intermittent, pulsating proportioning of a dialysis fluid mixture
BR112019023666A2 (en) * 2017-05-19 2020-06-02 Basf Coatings Gmbh PRODUCTION SYSTEM FOR MANUFACTURING FORMULATIONS, AND, PROCESS FOR MANUFACTURING FORMULATIONS
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GB201709531D0 (en) * 2017-06-15 2017-08-02 Ge Healthcare Bio Sciences Ab Method and apparatus for determining one or more buffer composition recipes
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EP3931559A1 (en) * 2019-02-28 2022-01-05 Cytiva Sweden AB Control of a buffer preparation process
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US11465110B2 (en) 2019-12-26 2022-10-11 Asahi Kasei Bioprocess America, Inc. Scaleable inline buffer dilution scheme
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US11899028B2 (en) * 2019-12-31 2024-02-13 Cytiva Us Llc Buffer management and identification in bioprocessing system
US20210197142A1 (en) * 2019-12-31 2021-07-01 Pall Corporation Buffer management system with manifold for bioprocessing system
JP7388206B2 (en) * 2020-01-22 2023-11-29 株式会社島津製作所 Liquid chromatography and analytical methods
CN111257316A (en) * 2020-02-11 2020-06-09 军事科学院系统工程研究院卫勤保障技术研究所 Portable nanometer detector
EP4179311A1 (en) 2020-07-07 2023-05-17 Waters Technologies Corporation Combination mixer arrangement for noise reduction in fluid chromatography
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Also Published As

Publication number Publication date
AU2010298776A1 (en) 2012-03-15
CN102549516A (en) 2012-07-04
CN107983261A (en) 2018-05-04
EP2480943A4 (en) 2014-10-08
JP5961112B2 (en) 2016-08-02
EP2480943B1 (en) 2017-07-12
WO2011037530A1 (en) 2011-03-31
EP2480943A1 (en) 2012-08-01
US20120217192A1 (en) 2012-08-30
US9327212B2 (en) 2016-05-03
JP2013506128A (en) 2013-02-21

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