IN2012DN01878A - - Google Patents

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Publication number
IN2012DN01878A
IN2012DN01878A IN1878DEN2012A IN2012DN01878A IN 2012DN01878 A IN2012DN01878 A IN 2012DN01878A IN 1878DEN2012 A IN1878DEN2012 A IN 1878DEN2012A IN 2012DN01878 A IN2012DN01878 A IN 2012DN01878A
Authority
IN
India
Prior art keywords
cancer
diseases
administration
prevention
compositions
Prior art date
Application number
Inventor
Michael Andrew Foley
Robert Gould
Peter Elliot
Anna Mandinova
Sam Lee
Original Assignee
Canthera Therapeutics Inc
Massachusetts Gen Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Canthera Therapeutics Inc, Massachusetts Gen Hospital filed Critical Canthera Therapeutics Inc
Publication of IN2012DN01878A publication Critical patent/IN2012DN01878A/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The invention relates to compounds and composition for the treatment and prevention of cancer. The invention also covers all diseases that may be treated by selective modulation of levels of reactive oxygen species in diseased cells versus normal cells. Methods for the preparation and administration of such compositions are also disclosed.
IN1878DEN2012 2009-09-02 2010-09-02 IN2012DN01878A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27575409P 2009-09-02 2009-09-02
PCT/US2010/047615 WO2011028860A2 (en) 2009-09-02 2010-09-02 Compounds and compositions for treating cancer

Publications (1)

Publication Number Publication Date
IN2012DN01878A true IN2012DN01878A (en) 2015-08-21

Family

ID=43625764

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1878DEN2012 IN2012DN01878A (en) 2009-09-02 2010-09-02

Country Status (9)

Country Link
EP (1) EP2473506A4 (en)
JP (1) JP2013503888A (en)
KR (1) KR20120104165A (en)
CN (1) CN102625805A (en)
AU (1) AU2010289493A1 (en)
BR (1) BR112012004701A2 (en)
CA (1) CA2772614A1 (en)
IN (1) IN2012DN01878A (en)
WO (1) WO2011028860A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101629642B1 (en) 2014-06-25 2016-06-13 서울대학교산학협력단 Food composition, pharmaceutical composition, animal medicine and feed composition against fatty liver with piperlongumine
GB201715008D0 (en) * 2017-09-18 2017-11-01 Inst De Medicina Molecular Faculdade De Medicina Univ De Lisboa TRPV2 Antagonists
KR20200081633A (en) 2018-12-27 2020-07-08 주식회사 티에스디라이프사이언스 A pharmaceutical composition for treatment or prevention of biliary atresia comprising piperlongumine
CN110002987B (en) * 2019-03-22 2020-09-15 南通大学 Phenylallylidene cyclohexenone derivative, preparation method and application thereof
CN117229205A (en) * 2023-09-14 2023-12-15 中国医学科学院基础医学研究所 Preparation method and pharmaceutical application of phenyl acrylamide RHbDD1 inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2478901A3 (en) 2007-02-14 2012-11-14 Mars Incorporated Neurogenic compounds
EP2135078B1 (en) * 2007-03-09 2013-08-21 DiscoveRx Corporation Methods for identifying agents and their use for the prevention or stabilization of fibrosis
CN102146054A (en) * 2010-02-10 2011-08-10 新昌县来益科技开发有限公司 Piperlongumine derivatives and medicinal composition and application to preparation of medicament for inhibiting tumor growth thereof

Also Published As

Publication number Publication date
EP2473506A4 (en) 2013-03-06
AU2010289493A1 (en) 2012-04-19
WO2011028860A2 (en) 2011-03-10
CN102625805A (en) 2012-08-01
KR20120104165A (en) 2012-09-20
BR112012004701A2 (en) 2018-06-12
CA2772614A1 (en) 2011-03-10
JP2013503888A (en) 2013-02-04
WO2011028860A3 (en) 2011-07-21
EP2473506A2 (en) 2012-07-11

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