IN2012DE00661A - - Google Patents
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- Publication number
- IN2012DE00661A IN2012DE00661A IN661DE2012A IN2012DE00661A IN 2012DE00661 A IN2012DE00661 A IN 2012DE00661A IN 661DE2012 A IN661DE2012 A IN 661DE2012A IN 2012DE00661 A IN2012DE00661 A IN 2012DE00661A
- Authority
- IN
- India
- Prior art keywords
- substituted
- hetero
- aminoquinoline
- aryl
- formula
- Prior art date
Links
- 125000003118 aryl group Chemical group 0.000 abstract 4
- -1 cyno Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- FQYRLEXKXQRZDH-UHFFFAOYSA-N 4-aminoquinoline Chemical compound C1=CC=C2C(N)=CC=NC2=C1 FQYRLEXKXQRZDH-UHFFFAOYSA-N 0.000 abstract 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- XEEQGYMUWCZPDN-DOMZBBRYSA-N (-)-(11S,2'R)-erythro-mefloquine Chemical compound C([C@@H]1[C@@H](O)C=2C3=CC=CC(=C3N=C(C=2)C(F)(F)F)C(F)(F)F)CCCN1 XEEQGYMUWCZPDN-DOMZBBRYSA-N 0.000 abstract 1
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 abstract 1
- ODOPLLNPLYGBPQ-UHFFFAOYSA-N 4-(dimethylamino)-1,5-dimethyl-2-phenylpyrazol-3-one;(5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl)-(6-methoxyquinolin-4-yl)methanol;1,3,7-trimethylpurine-2,6-dione;hydrochloride Chemical compound Cl.CN1C(=O)N(C)C(=O)C2=C1N=CN2C.O=C1C(N(C)C)=C(C)N(C)N1C1=CC=CC=C1.C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 ODOPLLNPLYGBPQ-UHFFFAOYSA-N 0.000 abstract 1
- WREVVZMUNPAPOV-UHFFFAOYSA-N 8-aminoquinoline Chemical compound C1=CN=C2C(N)=CC=CC2=C1 WREVVZMUNPAPOV-UHFFFAOYSA-N 0.000 abstract 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000005010 aminoquinolines Chemical class 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 150000002390 heteroarenes Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229960001962 mefloquine Drugs 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES13758678T ES2899730T3 (es) | 2012-03-07 | 2013-02-28 | Derivados de la aminoquinolina y sus usos |
| US14/382,727 US9567316B2 (en) | 2012-03-07 | 2013-02-28 | Aminoquinoline derivatives and uses thereof |
| IN661DE2012 IN2012DE00661A (enrdf_load_html_response) | 2012-03-07 | 2013-02-28 | |
| EP21194376.6A EP3971178A1 (en) | 2012-03-07 | 2013-02-28 | Aminoquinoline derivatives and uses thereof |
| PCT/US2013/028329 WO2013134047A2 (en) | 2012-03-07 | 2013-02-28 | Aminoquinoline derivatives and uses thereof |
| PT137586780T PT2822936T (pt) | 2012-03-07 | 2013-02-28 | Derivados da aminoquinolina e suas utilizações |
| EP13758678.0A EP2822936B1 (en) | 2012-03-07 | 2013-02-28 | Aminoquinoline derivatives and uses thereof |
| US15/404,964 US11026943B2 (en) | 2012-03-07 | 2017-01-12 | Aminoquinoline derivatives and uses thereof |
| US17/240,886 US20220008418A1 (en) | 2012-03-07 | 2021-04-26 | Aminoquinoline Derivatives and Uses Thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN661DE2012 IN2012DE00661A (enrdf_load_html_response) | 2012-03-07 | 2013-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DE00661A true IN2012DE00661A (enrdf_load_html_response) | 2015-08-21 |
Family
ID=49117483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN661DE2012 IN2012DE00661A (enrdf_load_html_response) | 2012-03-07 | 2013-02-28 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US9567316B2 (enrdf_load_html_response) |
| EP (2) | EP3971178A1 (enrdf_load_html_response) |
| ES (1) | ES2899730T3 (enrdf_load_html_response) |
| IN (1) | IN2012DE00661A (enrdf_load_html_response) |
| PT (1) | PT2822936T (enrdf_load_html_response) |
| WO (1) | WO2013134047A2 (enrdf_load_html_response) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10144932B2 (en) * | 2014-06-06 | 2018-12-04 | Board Of Trustees Of Michigan State University | Nurr1 as a genetic target for treating levodopa-induced dyskinesias in Parkinson's disease |
| CN104070943B (zh) * | 2014-07-23 | 2017-10-17 | 万通智控科技股份有限公司 | 一种自编程轮胎压力监测装置及实现方法 |
| WO2016111957A1 (en) * | 2015-01-06 | 2016-07-14 | Albert Einstein College Of Medicine, Inc. | Chloroquinoline triazole compounds, composition and uses |
| EP3260121A4 (en) * | 2015-02-16 | 2018-07-25 | Postech Academy-Industry Foundation | Composition for preventing, alleviating or treating metabolic diseases, containing amodiaquine as active ingredient |
| WO2016176222A1 (en) * | 2015-04-30 | 2016-11-03 | University Of Washington | Cgas in systemic lupus erythematosus (sle) |
| JP2018517743A (ja) | 2015-06-15 | 2018-07-05 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | 多系統萎縮症を治療するための自家間葉系幹細胞の使用 |
| CN105301126B (zh) * | 2015-10-10 | 2021-02-12 | 大道隆达（北京）医药科技发展有限公司 | 一种托匹司他有关物质的分析方法 |
| EP3498279A4 (en) * | 2016-08-12 | 2020-04-29 | Novmetapharma Co., Ltd. | PHARMACEUTICAL COMPOSITION COMPRISING AS ACTIVE INGREDIENTS OF AMODIAQUINE AND AN ANTI-DIABETES MEDICINE FOR THE PREVENTION OR TREATMENT OF DIABETES |
| EP3810126A4 (en) * | 2018-06-21 | 2022-04-27 | Board of Regents of the Nevada System of Higher Education, on Behalf of the University of Nevada, Reno | DISEASE MODIFICATION METHODS FOR TREATING NEURODEGENERATIVE DISEASES USING NOOTROPICS |
| CN109620971A (zh) * | 2018-12-14 | 2019-04-16 | 昆明医科大学第附属医院 | 一种筛选防治帕金森病药物的方法 |
| MA54261B1 (fr) * | 2019-01-18 | 2025-03-28 | Astrazeneca Ab | Inhibiteurs de pcsk9 et leurs procédés d'utilisation |
| CN114667145A (zh) * | 2019-08-22 | 2022-06-24 | 拜尔哈文制药股份有限公司 | 与tdp-43结合的用于治疗肌萎缩性侧索硬化症和相关病症的分子 |
| WO2021087077A1 (en) * | 2019-10-29 | 2021-05-06 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Small molecule inhibitors of autophagy and histone deactylases and uses thereof |
| WO2022010984A1 (en) * | 2020-07-07 | 2022-01-13 | The Mclean Hospital Corporation | Compounds and methods for treating neurodegenerative diseases |
| US20240148722A1 (en) * | 2021-02-20 | 2024-05-09 | Biohaven Therapeutics Ltd. | Small molecules that bind to tdp-43 for the treatment of als and related disorders |
| WO2023159062A2 (en) * | 2022-02-15 | 2023-08-24 | University Of Central Florida Research Foundation, Inc. | Anabolic drugs stimulating type ii collagen production from chondrocytes or their progenitors |
| WO2024049718A2 (en) * | 2022-08-31 | 2024-03-07 | Immunocure Inc. | Quinoline piperazine derivatives, pharmaceutical composition and uses thereof |
| WO2024092255A2 (en) * | 2022-10-28 | 2024-05-02 | Handford Mason J | 4-aminoquinolines for treatment of multidrug resistant malaria |
| WO2025024311A2 (en) * | 2023-07-21 | 2025-01-30 | Icahn School Of Medicine At Mount Sinai | G9a/glp inhibitors and methods of use |
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| US7125904B2 (en) | 2002-10-11 | 2006-10-24 | Portela & C.A., S.A. | Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation |
| US7323462B2 (en) | 2002-12-10 | 2008-01-29 | Pfizer Inc. | Morpholine dopamine agonists |
| WO2005004794A2 (en) | 2003-06-09 | 2005-01-20 | Alnylam Pharmaceuticals Inc. | Method of treating neurodegenerative disease |
| US8114892B2 (en) * | 2006-02-16 | 2012-02-14 | The Mclean Hospital Corporation | Methods and compositions for the treatment of Parkinson's Disease |
| WO2008036374A2 (en) * | 2006-09-21 | 2008-03-27 | Medistem Laboratories, Inc. | Allogeneic stem cell transplants in non-conditioned recipients |
| US20110045100A1 (en) | 2008-03-05 | 2011-02-24 | Georgetown University | Antimalarial Quinolines and Methods of Use Thereof |
| WO2010059738A1 (en) * | 2008-11-18 | 2010-05-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Differentiation of stem cells into dopaminergic cells |
| EP2379505A4 (en) * | 2008-12-05 | 2012-10-17 | Designmedix Inc | CHLOROQUINES MODIFIED BY A MONOCYCLIC GROUP OR A FUSED CYCLE GROUP |
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2013
- 2013-02-28 IN IN661DE2012 patent/IN2012DE00661A/en unknown
- 2013-02-28 PT PT137586780T patent/PT2822936T/pt unknown
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2017
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2021
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|---|---|
| US9567316B2 (en) | 2017-02-14 |
| EP3971178A1 (en) | 2022-03-23 |
| US20220008418A1 (en) | 2022-01-13 |
| EP2822936B1 (en) | 2021-09-08 |
| ES2899730T3 (es) | 2022-03-14 |
| EP2822936A2 (en) | 2015-01-14 |
| PT2822936T (pt) | 2021-12-02 |
| US20170209441A1 (en) | 2017-07-27 |
| EP2822936A4 (en) | 2016-04-20 |
| WO2013134047A3 (en) | 2013-10-31 |
| WO2013134047A2 (en) | 2013-09-12 |
| US20150023930A1 (en) | 2015-01-22 |
| US11026943B2 (en) | 2021-06-08 |
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