IN2010CH03098AIN3098CH2010AIN2010CH03098AIN 2010CH03098 AIN2010CH03098 AIN 2010CH03098AIN 3098CH2010 AIN3098CH2010 AIN 3098CH2010AIN 2010CH03098 AIN2010CH03098 AIN 2010CH03098A
Authority
IN
India
Prior art keywords
methoxy
hydroxy
acid
diphenylpropanoic acid
ethylamine
Prior art date
Application number
Inventor
Reddy Bandi Parthasaradhi
Reddy Kura Rathnakar
Reddy Dasari Muralidhara
Reddy Matta Ramakrishna
Krishna Bandi Vamsi
Original Assignee
Hetero Research Foundation
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Publication date
Application filed by Hetero Research FoundationfiledCriticalHetero Research Foundation
Priority to IN3098CH2010priorityCriticalpatent/IN2010CH03098A/en
Publication of IN2010CH03098ApublicationCriticalpatent/IN2010CH03098A/en
The present invention relates to process for optical resolution of 2-hydroxy-3- methoxy-3,3-diphenylpropanoic acid. Thus, for example, reacting racemic 2-hydroxy-3- methoxy-3,3-diphenylpropanoic acid with S-(-)-1-(1-naphtyl)ethylamine in acetone to obtain corresponding diastereomer salts. The diastereomeric salts were subjected to fractional crystallization to obtain (S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid ,S-(-)-1-(1-naphthyl)ethylamine. The separated isomer was dissolved in a mixture of water and methyl tert-butyl ether and pH was adjusted to 1.1 with concentrated hydrochloric acid to obtain (S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid.
New process for the resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3-5-trien-7-yl)nitrile and application in the synthesis of ivabradine
Preparation process of the intermediate compound 3-oxo-tetrahydrothiophene-2-carboxylic acid, useful in the preparation of dihydrothienopyrimidines (divisional of the application 3095-08).
Preparation procedure of ivabradine and its addition salts by formation of the benzoacepine ring; and the intermediary compounds considered in the process.