IL95764A - Datoxytosplosphorin C hydroxylase - Google Patents

Datoxytosplosphorin C hydroxylase

Info

Publication number
IL95764A
IL95764A IL9576490A IL9576490A IL95764A IL 95764 A IL95764 A IL 95764A IL 9576490 A IL9576490 A IL 9576490A IL 9576490 A IL9576490 A IL 9576490A IL 95764 A IL95764 A IL 95764A
Authority
IL
Israel
Prior art keywords
hydroxylase
buffer
activity
daoc
ala
Prior art date
Application number
IL9576490A
Other languages
English (en)
Hebrew (he)
Other versions
IL95764A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL95764A0 publication Critical patent/IL95764A0/xx
Publication of IL95764A publication Critical patent/IL95764A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/06Cephalosporin C; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Cephalosporin Compounds (AREA)
IL9576490A 1989-09-26 1990-09-24 Datoxytosplosphorin C hydroxylase IL95764A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41276189A 1989-09-26 1989-09-26

Publications (2)

Publication Number Publication Date
IL95764A0 IL95764A0 (en) 1991-06-30
IL95764A true IL95764A (en) 1995-03-15

Family

ID=23634379

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9576490A IL95764A (en) 1989-09-26 1990-09-24 Datoxytosplosphorin C hydroxylase

Country Status (9)

Country Link
US (1) US5714363A (de)
EP (1) EP0420562B1 (de)
JP (1) JPH03206884A (de)
AT (1) ATE121453T1 (de)
CA (1) CA2026041C (de)
DE (1) DE69018749T2 (de)
DK (1) DK0420562T3 (de)
ES (1) ES2072400T3 (de)
IL (1) IL95764A (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6709859B1 (en) 1986-01-31 2004-03-23 Beecham Group P.L.C. Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression
DE3789880T2 (de) * 1986-01-31 1994-09-08 Beecham Group Plc Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen.
US5571910A (en) * 1994-12-09 1996-11-05 Schering Corporation Process for the preparation of intermediates useful in the synthesis of cephalosporins

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1252973A (en) * 1915-05-03 1918-01-08 Roessler & Hasslacher Chemical Catalyzer and process of making the same.
US2689203A (en) * 1951-09-27 1954-09-14 Armour & Co Preparation of stabilized catalase
US3242056A (en) * 1962-06-08 1966-03-22 Lysofrance Soc Thermally stable lysozyme composition and process for preparing same
US3637462A (en) * 1969-04-21 1972-01-25 Wadley Res Inst & Blood Bank Purification of enzymes
US3761420A (en) * 1970-06-08 1973-09-25 Staley Mfg Co A E Stabilized liquid enzyme stain remover
US4693977A (en) * 1982-08-23 1987-09-15 Queen's University At Kingston Enzyme immobilization for producing cephalosporin antibiotics
US4536476A (en) * 1982-08-23 1985-08-20 Queen's University At Kingston Stable epimerase reagent, cyclase reagent and ring expansion reagent for cell-free production of cephalosporins

Also Published As

Publication number Publication date
DE69018749D1 (de) 1995-05-24
JPH03206884A (ja) 1991-09-10
DK0420562T3 (da) 1995-06-26
ATE121453T1 (de) 1995-05-15
ES2072400T3 (es) 1995-07-16
US5714363A (en) 1998-02-03
EP0420562B1 (de) 1995-04-19
DE69018749T2 (de) 1995-09-14
CA2026041C (en) 1999-09-07
CA2026041A1 (en) 1991-03-27
IL95764A0 (en) 1991-06-30
EP0420562A1 (de) 1991-04-03

Similar Documents

Publication Publication Date Title
Dotzlaf et al. Copurification and characterization of deacetoxycephalosporin C synthetase/hydroxylase from Cephalosporium acremonium
Alvarez et al. Purification to homogeneity and characterization of acyl coenzyme A: 6-aminopenicillanic acid acyltransferase of Penicillium chrysogenum
US6017726A (en) Bioprocesses for preparing 7-ACA and 7-ADAC
US5318896A (en) Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
US4693977A (en) Enzyme immobilization for producing cephalosporin antibiotics
US4536476A (en) Stable epimerase reagent, cyclase reagent and ring expansion reagent for cell-free production of cephalosporins
US5082772A (en) Process for preparing deacetylcephalosporin c
US4510246A (en) Isolation of cyclase, epimerase and a ring expansion enzyme for producing unnatural cephalosporins
Baker et al. Deacetoxycephalosporin C hydroxylase of Streptomyces clavuligerus. Purification, characterization, bifunctionality, and evolutionary implication.
EP0436355B1 (de) Verfahren zur Herstellung von 7-Aminocephem-Verbindungen oder deren Salzen
US5571685A (en) Morphinone reductase for the preparation of hydromorphone and hydrocodone
US5714363A (en) Deacetoxycephalosporin C hydroxylase
US5328839A (en) Oxido reductase enzyme system obtained from P. chrysogenum
US4753881A (en) Purified enzyme and process therefor
HU205626B (en) Process for producing recombinant exprassive dns-vectors coding isopenicillin-n synthetase enzyme of aspergillus nidulans or for producing dns-molekules
US4579818A (en) Biosynthesis of unnatural cephalosporins
US5753435A (en) Oxido reductase enzyme system obtainable from P. chrysogenum, the set of genes encoding the same and the use of oxido reductase enzyme systems or genes encoding the same for increasing antibiotic production
EP0403172A2 (de) Gereinigtes Enzym und Verfahren dazu
CA1206901A (en) Biosynthesis of unnatural cephalosporins

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees