IL94067A - שיטה ומתקן למיום תאים או גופים מיוצרים באוכלוסיות עם תכונות נבחרות, בשימוש פרמטר חושי אחד לפחות - Google Patents
שיטה ומתקן למיום תאים או גופים מיוצרים באוכלוסיות עם תכונות נבחרות, בשימוש פרמטר חושי אחד לפחותInfo
- Publication number
- IL94067A IL94067A IL9406790A IL9406790A IL94067A IL 94067 A IL94067 A IL 94067A IL 9406790 A IL9406790 A IL 9406790A IL 9406790 A IL9406790 A IL 9406790A IL 94067 A IL94067 A IL 94067A
- Authority
- IL
- Israel
- Prior art keywords
- blood cell
- white blood
- subset
- population
- sample
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 86
- 238000012216 screening Methods 0.000 title description 11
- 210000000265 leukocyte Anatomy 0.000 claims abstract description 309
- 210000004369 blood Anatomy 0.000 claims abstract description 122
- 239000008280 blood Substances 0.000 claims abstract description 122
- 238000004458 analytical method Methods 0.000 claims abstract description 65
- 210000000601 blood cell Anatomy 0.000 claims abstract description 11
- 230000000779 depleting effect Effects 0.000 claims abstract 5
- 239000004005 microsphere Substances 0.000 claims description 164
- 210000003743 erythrocyte Anatomy 0.000 claims description 123
- 238000002156 mixing Methods 0.000 claims description 35
- 210000000440 neutrophil Anatomy 0.000 claims description 15
- 210000003979 eosinophil Anatomy 0.000 claims description 11
- 210000004698 lymphocyte Anatomy 0.000 claims description 11
- 230000002708 enhancing effect Effects 0.000 claims description 8
- 210000003651 basophil Anatomy 0.000 claims description 7
- 238000000149 argon plasma sintering Methods 0.000 claims description 6
- 210000001616 monocyte Anatomy 0.000 claims description 6
- 230000002411 adverse Effects 0.000 claims description 5
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 abstract description 151
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- 239000000523 sample Substances 0.000 description 213
- 239000000203 mixture Substances 0.000 description 133
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- 238000004163 cytometry Methods 0.000 description 10
- 238000010586 diagram Methods 0.000 description 10
- 238000011282 treatment Methods 0.000 description 10
- 210000003719 b-lymphocyte Anatomy 0.000 description 9
- 230000007246 mechanism Effects 0.000 description 8
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- 230000002934 lysing effect Effects 0.000 description 7
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- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
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- 230000003287 optical effect Effects 0.000 description 5
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 4
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 4
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- 239000000427 antigen Substances 0.000 description 4
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- 108091007433 antigens Proteins 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 238000000684 flow cytometry Methods 0.000 description 4
- 210000003714 granulocyte Anatomy 0.000 description 4
- 210000005259 peripheral blood Anatomy 0.000 description 4
- 239000011886 peripheral blood Substances 0.000 description 4
- 238000005070 sampling Methods 0.000 description 4
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- 239000011248 coating agent Substances 0.000 description 3
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- 241000894006 Bacteria Species 0.000 description 2
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 description 2
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- 210000000712 G cell Anatomy 0.000 description 2
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 description 2
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 238000011161 development Methods 0.000 description 2
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
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- 239000000126 substance Substances 0.000 description 2
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- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 210000004366 CD4-positive T-lymphocyte Anatomy 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 102100038796 E3 ubiquitin-protein ligase TRIM13 Human genes 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 229920001917 Ficoll Polymers 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 101000664589 Homo sapiens E3 ubiquitin-protein ligase TRIM13 Proteins 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 241000023320 Luma <angiosperm> Species 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- AXIKDPDWFVPGOD-UHFFFAOYSA-O [7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium;2-(2,4,5,7-tetrabromo-3,6-dihydroxyxanthen-10-ium-9-yl)benzoic acid Chemical compound C1=CC(=[N+](C)C)C=C2SC3=CC(N(C)C)=CC=C3N=C21.OC(=O)C1=CC=CC=C1C1=C(C=C(Br)C(O)=C2Br)C2=[O+]C2=C1C=C(Br)C(O)=C2Br AXIKDPDWFVPGOD-UHFFFAOYSA-O 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 210000004970 cd4 cell Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000005206 flow analysis Methods 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
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- 230000009390 immune abnormality Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 210000000207 lymphocyte subset Anatomy 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000011527 multiparameter analysis Methods 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 210000005105 peripheral blood lymphocyte Anatomy 0.000 description 1
- 102000013415 peroxidase activity proteins Human genes 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
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- 230000002062 proliferating effect Effects 0.000 description 1
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- 238000012360 testing method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
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- 230000009385 viral infection Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1024—Counting particles by non-optical means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1028—Sorting particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1486—Counting the particles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33915689A | 1989-04-14 | 1989-04-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL94067A0 IL94067A0 (en) | 1991-01-31 |
| IL94067A true IL94067A (he) | 1994-12-29 |
Family
ID=23327761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9406790A IL94067A (he) | 1989-04-14 | 1990-04-12 | שיטה ומתקן למיום תאים או גופים מיוצרים באוכלוסיות עם תכונות נבחרות, בשימוש פרמטר חושי אחד לפחות |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0467952B1 (he) |
| JP (1) | JPH10502163A (he) |
| CN (1) | CN1050771A (he) |
| AT (1) | ATE142332T1 (he) |
| AU (1) | AU635020B2 (he) |
| CA (1) | CA1333047C (he) |
| DE (1) | DE69028399T2 (he) |
| IL (1) | IL94067A (he) |
| WO (1) | WO1990013013A1 (he) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5262302A (en) * | 1987-03-13 | 1993-11-16 | Coulter Corporation | Method for screening white blood cells |
| US6159740A (en) * | 1987-03-13 | 2000-12-12 | Coulter Corporation | Method and apparatus for screening obscured or partially obscured cells |
| US5466609A (en) * | 1990-10-31 | 1995-11-14 | Coulter Corporation | Biodegradable gelatin-aminodextran particle coatings of and processes for making same |
| US5348859A (en) * | 1990-11-23 | 1994-09-20 | Coulter Corporation | Method and apparatus for obtaining an absolute white blood cell subset count and white blood cell multipart differential |
| ATE160170T1 (de) * | 1991-02-22 | 1997-11-15 | Coulter Corp | Verfahren und vorrichtung zum reihensichten mikroskopischer zellen unter verwendung von techniken zur streuung polarisierten lichts |
| US5576185A (en) | 1994-04-15 | 1996-11-19 | Coulter Corporation | Method of positive or negative selection of a population or subpopulation of a sample utilizing particles and gravity sedimentation |
| JP2000500388A (ja) * | 1995-11-13 | 2000-01-18 | コールター インターナショナル コーポレイション | 粒子および重力沈降を使用するサンプルの集団または下位集団を選択する方法 |
| SG190777A1 (en) | 2010-11-09 | 2013-07-31 | Gen Hospital Corp | Counting particles using an electrical differential counter |
| CN104297133B (zh) * | 2013-07-16 | 2017-01-25 | 成都深迈瑞医疗电子技术研究院有限公司 | 一种基于小孔阻抗原理的脉冲信号筛选方法及装置 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4219411A (en) * | 1978-09-18 | 1980-08-26 | California Institute Of Technology | Cell sorting apparatus |
| US4452773A (en) * | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
| US4599307A (en) * | 1983-07-18 | 1986-07-08 | Becton, Dickinson And Company | Method for elimination of selected cell populations in analytic cytology |
| US4727020A (en) * | 1985-02-25 | 1988-02-23 | Becton, Dickinson And Company | Method for analysis of subpopulations of blood cells |
| JPS61225656A (ja) * | 1985-03-29 | 1986-10-07 | Toshiba Corp | 検体検査装置 |
| CA1311404C (en) * | 1987-03-13 | 1992-12-15 | Kenneth H. Kortright | Automated analyzer and method for screening cells or formed bodies for enumeration of populations expressing selected characteristics |
| CA1339840C (en) * | 1988-12-16 | 1998-04-28 | Kenneth Kortright | Method and apparatus for screening cells or formed bodies with populations expressing selected characteristics |
-
1989
- 1989-09-20 CA CA000612192A patent/CA1333047C/en not_active Expired - Fee Related
-
1990
- 1990-04-06 DE DE69028399T patent/DE69028399T2/de not_active Expired - Fee Related
- 1990-04-06 WO PCT/US1990/001880 patent/WO1990013013A1/en not_active Ceased
- 1990-04-06 EP EP90906509A patent/EP0467952B1/en not_active Expired - Lifetime
- 1990-04-06 JP JP2506196A patent/JPH10502163A/ja active Pending
- 1990-04-06 AU AU54388/90A patent/AU635020B2/en not_active Ceased
- 1990-04-06 AT AT90906509T patent/ATE142332T1/de not_active IP Right Cessation
- 1990-04-12 IL IL9406790A patent/IL94067A/he not_active IP Right Cessation
- 1990-04-14 CN CN90103926.8A patent/CN1050771A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0467952A4 (en) | 1992-12-30 |
| EP0467952A1 (en) | 1992-01-29 |
| DE69028399D1 (de) | 1996-10-10 |
| EP0467952B1 (en) | 1996-09-04 |
| WO1990013013A1 (en) | 1990-11-01 |
| AU635020B2 (en) | 1993-03-11 |
| CA1333047C (en) | 1994-11-15 |
| AU5438890A (en) | 1990-11-16 |
| ATE142332T1 (de) | 1996-09-15 |
| DE69028399T2 (de) | 1997-04-10 |
| JPH10502163A (ja) | 1998-02-24 |
| IL94067A0 (en) | 1991-01-31 |
| CN1050771A (zh) | 1991-04-17 |
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| US5260192A (en) | Method and apparatus for screening cells or formed bodies with populations expressing selected characteristics utilizing at least one sensing parameter | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH | Patent void |