IL92015A0 - Tissue plasminogen activator muteins and processes for the preparation thereof - Google Patents

Tissue plasminogen activator muteins and processes for the preparation thereof

Info

Publication number
IL92015A0
IL92015A0 IL92015A IL9201589A IL92015A0 IL 92015 A0 IL92015 A0 IL 92015A0 IL 92015 A IL92015 A IL 92015A IL 9201589 A IL9201589 A IL 9201589A IL 92015 A0 IL92015 A0 IL 92015A0
Authority
IL
Israel
Prior art keywords
muteins
processes
preparation
plasminogen activator
tissue plasminogen
Prior art date
Application number
IL92015A
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of IL92015A0 publication Critical patent/IL92015A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL92015A 1988-10-24 1989-10-17 Tissue plasminogen activator muteins and processes for the preparation thereof IL92015A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3836200A DE3836200A1 (en) 1988-10-24 1988-10-24 DOMAIN DUPLICATION MUTEINE OF THE TISSUE PLASMINOGEN ACTIVATOR (T-PA)

Publications (1)

Publication Number Publication Date
IL92015A0 true IL92015A0 (en) 1990-07-12

Family

ID=6365810

Family Applications (1)

Application Number Title Priority Date Filing Date
IL92015A IL92015A0 (en) 1988-10-24 1989-10-17 Tissue plasminogen activator muteins and processes for the preparation thereof

Country Status (6)

Country Link
EP (1) EP0366091A3 (en)
JP (1) JPH02215384A (en)
AU (1) AU609337B2 (en)
DE (1) DE3836200A1 (en)
DK (1) DK528989A (en)
IL (1) IL92015A0 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR880700856A (en) * 1985-12-20 1988-04-12 로버어트 에이 아미테이지 Tissue plasminogen activator (TPA) analog
JPS63501841A (en) * 1985-12-20 1988-07-28 ジ・アップジョン・カンパニ− Tissue plasminogen activator (TPA) homologues
ATE70301T1 (en) * 1986-02-17 1991-12-15 Stichting Centraal Lab TISSUE PLASMINOGEN ACTIVATOR MUTANT, ENCODING RECOMBINANT GENETIC INFORMATION THEREOF AND METHODS FOR THE PRODUCTION OF SUCH MUTANTS, THEIR USE AND PHARMACEUTICAL COMPOSITIONS.
GB8608020D0 (en) * 1986-04-02 1986-05-08 Beecham Group Plc Compounds
ATE110772T1 (en) * 1987-06-04 1994-09-15 Zymogenetics Inc MUTANT T-PA WITH KRINGLE REPLACEMENT.

Also Published As

Publication number Publication date
AU4365789A (en) 1990-04-26
DE3836200A1 (en) 1990-04-26
JPH02215384A (en) 1990-08-28
EP0366091A2 (en) 1990-05-02
EP0366091A3 (en) 1990-09-05
DK528989A (en) 1990-04-25
DK528989D0 (en) 1989-10-24
AU609337B2 (en) 1991-04-26

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