IL92015A0 - Tissue plasminogen activator muteins and processes for the preparation thereof - Google Patents

Tissue plasminogen activator muteins and processes for the preparation thereof

Info

Publication number
IL92015A0
IL92015A0 IL92015A IL9201589A IL92015A0 IL 92015 A0 IL92015 A0 IL 92015A0 IL 92015 A IL92015 A IL 92015A IL 9201589 A IL9201589 A IL 9201589A IL 92015 A0 IL92015 A0 IL 92015A0
Authority
IL
Israel
Prior art keywords
muteins
processes
preparation
plasminogen activator
tissue plasminogen
Prior art date
Application number
IL92015A
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of IL92015A0 publication Critical patent/IL92015A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL92015A 1988-10-24 1989-10-17 Tissue plasminogen activator muteins and processes for the preparation thereof IL92015A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3836200A DE3836200A1 (en) 1988-10-24 1988-10-24 DOMAIN DUPLICATION MUTEINE OF THE TISSUE PLASMINOGEN ACTIVATOR (T-PA)

Publications (1)

Publication Number Publication Date
IL92015A0 true IL92015A0 (en) 1990-07-12

Family

ID=6365810

Family Applications (1)

Application Number Title Priority Date Filing Date
IL92015A IL92015A0 (en) 1988-10-24 1989-10-17 Tissue plasminogen activator muteins and processes for the preparation thereof

Country Status (6)

Country Link
EP (1) EP0366091A3 (en)
JP (1) JPH02215384A (en)
AU (1) AU609337B2 (en)
DE (1) DE3836200A1 (en)
DK (1) DK528989A (en)
IL (1) IL92015A0 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63501841A (en) * 1985-12-20 1988-07-28 ジ・アップジョン・カンパニ− Tissue plasminogen activator (TPA) homologues
KR950000303B1 (en) * 1985-12-20 1995-01-13 디 엎죤 캄파니 Tissue plasminogen activator (tpa) analogs
EP0234051B1 (en) * 1986-02-17 1991-12-11 Stichting Centraal Laboratorium van de Bloedtransfusiedienst van het Nederlandse Rode Kruis Tissue-type plasminogen activator mutants; recombinant genetic information coding therefor and process for preparing said mutants; their use and pharmaceutical compositions
GB8608020D0 (en) * 1986-04-02 1986-05-08 Beecham Group Plc Compounds
EP0293934B1 (en) * 1987-06-04 1994-08-31 Zymogenetics, Inc. Mutant t-PA with kringle replacement

Also Published As

Publication number Publication date
AU4365789A (en) 1990-04-26
EP0366091A2 (en) 1990-05-02
DE3836200A1 (en) 1990-04-26
EP0366091A3 (en) 1990-09-05
DK528989D0 (en) 1989-10-24
AU609337B2 (en) 1991-04-26
DK528989A (en) 1990-04-25
JPH02215384A (en) 1990-08-28

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