IL90893A0 - Light diffraction assay using dna sequences as probes,manufacture of dna such probes and reagents therefor - Google Patents
Light diffraction assay using dna sequences as probes,manufacture of dna such probes and reagents thereforInfo
- Publication number
- IL90893A0 IL90893A0 IL90893A IL9089389A IL90893A0 IL 90893 A0 IL90893 A0 IL 90893A0 IL 90893 A IL90893 A IL 90893A IL 9089389 A IL9089389 A IL 9089389A IL 90893 A0 IL90893 A0 IL 90893A0
- Authority
- IL
- Israel
- Prior art keywords
- probes
- dna
- manufacture
- light diffraction
- dna sequences
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4788—Diffraction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N2021/757—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated using immobilised reagents
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/216,691 US5089387A (en) | 1988-07-07 | 1988-07-07 | Dna probe diffraction assay and reagents |
Publications (1)
Publication Number | Publication Date |
---|---|
IL90893A0 true IL90893A0 (en) | 1990-02-09 |
Family
ID=22808121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL90893A IL90893A0 (en) | 1988-07-07 | 1989-07-06 | Light diffraction assay using dna sequences as probes,manufacture of dna such probes and reagents therefor |
Country Status (6)
Country | Link |
---|---|
US (1) | US5089387A (xx) |
EP (1) | EP0350073A3 (xx) |
JP (1) | JPH02118437A (xx) |
AU (1) | AU3793289A (xx) |
CA (1) | CA1339117C (xx) |
IL (1) | IL90893A0 (xx) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6060237A (en) * | 1985-02-26 | 2000-05-09 | Biostar, Inc. | Devices and methods for optical detection of nucleic acid hybridization |
US5482830A (en) * | 1986-02-25 | 1996-01-09 | Biostar, Inc. | Devices and methods for detection of an analyte based upon light interference |
US5756126A (en) * | 1991-05-29 | 1998-05-26 | Flinders Technologies Pty. Ltd. | Dry solid medium for storage and analysis of genetic material |
US5807527A (en) * | 1991-05-29 | 1998-09-15 | Flinders Technologies Pty. Ltd. | Solid medium and method for DNA storage |
US6627226B2 (en) | 1988-10-05 | 2003-09-30 | Whatman, Inc. | Dry solid medium for storage and analysis of genetic material |
US5985327A (en) * | 1988-10-05 | 1999-11-16 | Flinders Technologies Pty. Ltd. | Solid medium and method for DNA storage |
US20040014068A1 (en) * | 1988-10-05 | 2004-01-22 | Whatman, Inc. | Solid medium and method for DNA storage |
US5541057A (en) * | 1989-09-18 | 1996-07-30 | Biostar, Inc. | Methods for detection of an analyte |
US5639671A (en) * | 1989-09-18 | 1997-06-17 | Biostar, Inc. | Methods for optimizing of an optical assay device |
IE911670A1 (en) * | 1990-05-17 | 1991-11-20 | Adeza Biomedical Corp | Highly reflective biogratings and method |
US5550063A (en) * | 1991-02-11 | 1996-08-27 | Biostar, Inc. | Methods for production of an optical assay device |
US5955377A (en) * | 1991-02-11 | 1999-09-21 | Biostar, Inc. | Methods and kits for the amplification of thin film based assays |
US5418136A (en) * | 1991-10-01 | 1995-05-23 | Biostar, Inc. | Devices for detection of an analyte based upon light interference |
JPH05236997A (ja) * | 1992-02-28 | 1993-09-17 | Hitachi Ltd | ポリヌクレオチド捕捉用チップ |
US5494829A (en) * | 1992-07-31 | 1996-02-27 | Biostar, Inc. | Devices and methods for detection of an analyte based upon light interference |
GB2273772A (en) * | 1992-12-16 | 1994-06-29 | Granta Lab Ltd | Detection of macromolecules utilising light diffraction |
US5314829A (en) * | 1992-12-18 | 1994-05-24 | California Institute Of Technology | Method for imaging informational biological molecules on a semiconductor substrate |
US5552272A (en) * | 1993-06-10 | 1996-09-03 | Biostar, Inc. | Detection of an analyte by fluorescence using a thin film optical device |
US5413939A (en) * | 1993-06-29 | 1995-05-09 | First Medical, Inc. | Solid-phase binding assay system for interferometrically measuring analytes bound to an active receptor |
DE4435998C1 (de) * | 1994-10-08 | 1995-11-30 | Forschungszentrum Juelich Gmbh | Verfahren zur Immobilisierung von Biomaterial auf einer Unterlage |
FR2737012B1 (fr) * | 1995-07-19 | 1997-09-12 | Suisse Electronique Microtech | Dispositif comprenant une substance biologiquement active immobilisee sur un substrat nitrure covalent par un agent de liaison bifonctionnel |
US5679579A (en) * | 1996-01-29 | 1997-10-21 | First Medical, Inc. | Immunofluorescence measurement of analytes bound to a substrate and apparatus therefor |
DE19612356B4 (de) * | 1996-03-28 | 2007-04-26 | Clondiag Chip Technologies Gmbh | Optischer Nachweis von Hybridisierungs-Signalen |
US5827748A (en) * | 1997-01-24 | 1998-10-27 | The United States Of America As Represented By The Secretary Of The Navy | Chemical sensor using two-dimensional lens array |
US5958704A (en) | 1997-03-12 | 1999-09-28 | Ddx, Inc. | Sensing system for specific substance and molecule detection |
US5935785A (en) * | 1997-04-30 | 1999-08-10 | Motorola, Inc. | Binding assay methods |
US6391655B1 (en) * | 1997-07-30 | 2002-05-21 | Corning Incorporated | Oxidized styrenic polymers for DNA binding |
US6394952B1 (en) | 1998-02-03 | 2002-05-28 | Adeza Biomedical Corporation | Point of care diagnostic systems |
US6267722B1 (en) | 1998-02-03 | 2001-07-31 | Adeza Biomedical Corporation | Point of care diagnostic systems |
USD432244S (en) | 1998-04-20 | 2000-10-17 | Adeza Biomedical Corporation | Device for encasing an assay test strip |
USD434153S (en) | 1998-04-20 | 2000-11-21 | Adeza Biomedical Corporation | Point of care analyte detector system |
US7008794B2 (en) * | 2000-03-22 | 2006-03-07 | Axela Biosensors Inc. | Method and apparatus for assay for multiple analytes |
US7465540B2 (en) | 2000-09-21 | 2008-12-16 | Luminex Corporation | Multiple reporter read-out for bioassays |
EP1434994A2 (en) * | 2001-09-13 | 2004-07-07 | Axela Biosensors Inc. | Method and apparatus for assay based on light diffraction |
WO2003036225A1 (en) * | 2001-10-26 | 2003-05-01 | University Of Rochester | Method for biomolecular sensing and system thereof |
US20050221283A1 (en) * | 2001-12-11 | 2005-10-06 | Mahant Vijay K | Biochip |
US7102752B2 (en) * | 2001-12-11 | 2006-09-05 | Kimberly-Clark Worldwide, Inc. | Systems to view and analyze the results from diffraction-based diagnostics |
US7098041B2 (en) * | 2001-12-11 | 2006-08-29 | Kimberly-Clark Worldwide, Inc. | Methods to view and analyze the results from diffraction-based diagnostics |
US20030138570A1 (en) * | 2001-12-21 | 2003-07-24 | Kimberly-Clark Worldwide, Inc. | Method to prepare diagnostic films using engraved printing cylinders such as rotogravure |
US7223534B2 (en) * | 2002-05-03 | 2007-05-29 | Kimberly-Clark Worldwide, Inc. | Diffraction-based diagnostic devices |
US7118855B2 (en) * | 2002-05-03 | 2006-10-10 | Kimberly-Clark Worldwide, Inc. | Diffraction-based diagnostic devices |
US7771922B2 (en) * | 2002-05-03 | 2010-08-10 | Kimberly-Clark Worldwide, Inc. | Biomolecule diagnostic device |
US7214530B2 (en) * | 2002-05-03 | 2007-05-08 | Kimberly-Clark Worldwide, Inc. | Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices |
US7223368B2 (en) * | 2002-05-03 | 2007-05-29 | Kimberly-Clark Worldwide, Inc. | Diffraction-based diagnostic devices |
US7485453B2 (en) * | 2002-05-03 | 2009-02-03 | Kimberly-Clark Worldwide, Inc. | Diffraction-based diagnostic devices |
US7091049B2 (en) * | 2002-06-26 | 2006-08-15 | Kimberly-Clark Worldwide, Inc. | Enhanced diffraction-based biosensor devices |
US7901630B2 (en) * | 2002-08-20 | 2011-03-08 | Illumina, Inc. | Diffraction grating-based encoded microparticle assay stick |
AU2003265583C1 (en) * | 2002-08-20 | 2009-05-21 | Cyvera Corporation | Diffraction grating-based optical identification element |
WO2004019277A1 (en) * | 2002-08-20 | 2004-03-04 | Cyvera Corporation | Diffraction grating-based encoded micro-particles for multiplexed experiments |
US7164533B2 (en) * | 2003-01-22 | 2007-01-16 | Cyvera Corporation | Hybrid random bead/chip based microarray |
US7441703B2 (en) * | 2002-08-20 | 2008-10-28 | Illumina, Inc. | Optical reader for diffraction grating-based encoded optical identification elements |
US7872804B2 (en) * | 2002-08-20 | 2011-01-18 | Illumina, Inc. | Encoded particle having a grating with variations in the refractive index |
US7399643B2 (en) * | 2002-09-12 | 2008-07-15 | Cyvera Corporation | Method and apparatus for aligning microbeads in order to interrogate the same |
US20050227252A1 (en) * | 2002-08-20 | 2005-10-13 | Moon John A | Diffraction grating-based encoded articles for multiplexed experiments |
US7508608B2 (en) * | 2004-11-17 | 2009-03-24 | Illumina, Inc. | Lithographically fabricated holographic optical identification element |
US7900836B2 (en) * | 2002-08-20 | 2011-03-08 | Illumina, Inc. | Optical reader system for substrates having an optically readable code |
US7923260B2 (en) | 2002-08-20 | 2011-04-12 | Illumina, Inc. | Method of reading encoded particles |
EP1540592A1 (en) * | 2002-09-12 | 2005-06-15 | Cyvera Corporation | Method and apparatus for labeling using diffraction grating-based encoded optical identification elements |
CA2498913A1 (en) * | 2002-09-12 | 2004-03-25 | Cyvera Corporation | Assay stick comprising coded microbeads |
AU2003270726A1 (en) * | 2002-09-12 | 2004-04-30 | Cidra Corporation | Diffraction grating-based encoded micro-particles for multiplexed experiments |
US20100255603A9 (en) * | 2002-09-12 | 2010-10-07 | Putnam Martin A | Method and apparatus for aligning microbeads in order to interrogate the same |
CA2498916A1 (en) * | 2002-09-12 | 2004-03-25 | Cyvera Corporation | Chemical synthesis using diffraction grating-based encoded optical elements |
US7092160B2 (en) * | 2002-09-12 | 2006-08-15 | Illumina, Inc. | Method of manufacturing of diffraction grating-based optical identification element |
US7169550B2 (en) * | 2002-09-26 | 2007-01-30 | Kimberly-Clark Worldwide, Inc. | Diffraction-based diagnostic devices |
DE10324912A1 (de) * | 2003-05-30 | 2005-01-05 | Siemens Ag | Verfahren zur Detektion von DNA-Punktmutationen (SNP-Analyse) sowie zugehörige Anordnung |
US20060057729A1 (en) * | 2003-09-12 | 2006-03-16 | Illumina, Inc. | Diffraction grating-based encoded element having a substance disposed thereon |
US6829073B1 (en) * | 2003-10-20 | 2004-12-07 | Corning Incorporated | Optical reading system and method for spectral multiplexing of resonant waveguide gratings |
US7433123B2 (en) * | 2004-02-19 | 2008-10-07 | Illumina, Inc. | Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein |
CA2604075C (en) * | 2004-04-09 | 2011-03-29 | Research Think Tank, Inc. | Devices and methods for collection, storage and transportation of biological specimens |
WO2006020363A2 (en) * | 2004-07-21 | 2006-02-23 | Illumina, Inc. | Method and apparatus for drug product tracking using encoded optical identification elements |
WO2006012744A1 (en) * | 2004-08-04 | 2006-02-09 | Axela Biosensors Inc. | Patterned surfaces with chemical crosslinkers for use in diffraction-based sensing |
DE602005019791D1 (de) * | 2004-11-16 | 2010-04-15 | Illumina Inc | Verfahren und vorrichtung zum lesen von kodierten mikrokugeln |
WO2006055735A2 (en) | 2004-11-16 | 2006-05-26 | Illumina, Inc | Scanner having spatial light modulator |
US7604173B2 (en) * | 2004-11-16 | 2009-10-20 | Illumina, Inc. | Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same |
US20130224850A1 (en) * | 2005-04-01 | 2013-08-29 | Ronald E. Meyers | Device and method for detecting bacterial endospores that are suspended in the atmosphere |
US7551294B2 (en) * | 2005-09-16 | 2009-06-23 | University Of Rochester | System and method for brewster angle straddle interferometry |
US7623624B2 (en) * | 2005-11-22 | 2009-11-24 | Illumina, Inc. | Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction |
US20070190536A1 (en) * | 2006-02-16 | 2007-08-16 | Academia Sinica | Method for using biomaterials as reagent for nano-patterning |
US7830575B2 (en) * | 2006-04-10 | 2010-11-09 | Illumina, Inc. | Optical scanner with improved scan time |
US7692798B2 (en) * | 2006-09-15 | 2010-04-06 | Adarza Biosystems, Inc. | Method for biomolecular detection and system thereof |
FR2935804B1 (fr) * | 2008-09-11 | 2012-11-02 | Innopsys | Procede de recherche d'au moins un analyte dans un milieu susceptible de le contenir |
US8975087B2 (en) | 2010-11-24 | 2015-03-10 | Inanovate, Inc. | Longitudinal assay |
DE102013112415A1 (de) * | 2013-11-12 | 2015-05-13 | Ludwig-Maximilians-Universität München | Vorrichtung und Verfahren zur Untersuchung eines oder mehrerer Phasenobjekte |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4054646A (en) * | 1973-07-30 | 1977-10-18 | General Electric | Method and apparatus for detection of antibodies and antigens |
CA1025772A (en) * | 1972-06-26 | 1978-02-07 | Ivar Giaever | Method and apparatus for detection and purification of proteins and antibodies |
US3853467A (en) * | 1973-08-15 | 1974-12-10 | Gen Electric | Method and apparatus for immunological detection of biological particles |
US4011308A (en) * | 1974-01-04 | 1977-03-08 | General Electric Company | Method for surface immunological detection of biological particles by the use of tagged antibodies |
US3926564A (en) * | 1974-02-25 | 1975-12-16 | Gen Electric | Substrate for immunological tests and method of fabrication thereof |
IT1033240B (it) * | 1974-03-14 | 1979-07-10 | Grapho Metronic Gmbh & Co | Umidificatore in una macchina stampatrice offset con un dispositivo per la regolazione del quantitativo d acqua sulla piastra |
US3960490A (en) * | 1974-04-01 | 1976-06-01 | General Electric Company | Method and apparatus for detecting immunologic reactions by diffusion in gel |
US3960488A (en) * | 1974-04-01 | 1976-06-01 | General Electric Company | Method and apparatus for quantitative surface inhibition test |
US3979509A (en) * | 1974-09-03 | 1976-09-07 | General Electric Company | Opaque layer method for detecting biological particles |
US3979184A (en) * | 1975-05-27 | 1976-09-07 | General Electric Company | Diagnostic device for visually detecting presence of biological particles |
US3975238A (en) * | 1975-06-26 | 1976-08-17 | General Electric Company | Method and apparatus for detecting molecules in solutions |
US4018886A (en) * | 1975-07-01 | 1977-04-19 | General Electric Company | Diagnostic method and device employing protein-coated magnetic particles |
US4115535A (en) * | 1977-06-22 | 1978-09-19 | General Electric Company | Diagnostic method employing a mixture of normally separable protein-coated particles |
US4181501A (en) * | 1979-03-26 | 1980-01-01 | General Electric Company | Method and apparatus for measuring antibody levels |
DE3135196A1 (de) * | 1981-09-05 | 1983-03-17 | Merck Patent Gmbh, 6100 Darmstadt | Verfahren, mittel und vorrichtung zur bestimmung biologischer komponenten |
US4621063A (en) * | 1982-10-12 | 1986-11-04 | The Center For Immunological Studies | Methods for the detection and quantitation of immunological substances |
DE3376685D1 (en) * | 1982-12-21 | 1988-06-23 | Ares Serono Nv | Assay technique |
US4487839A (en) * | 1983-01-05 | 1984-12-11 | Ortho Diagnostic Systems Inc. | Immunoassay methods employing patterns for the detection of soluble and cell surface antigens |
US4689295A (en) * | 1983-01-20 | 1987-08-25 | Integrated Genetics, Inc. | Test for Salmonella |
US4537861A (en) * | 1983-02-03 | 1985-08-27 | Elings Virgil B | Apparatus and method for homogeneous immunoassay |
GB8314523D0 (en) * | 1983-05-25 | 1983-06-29 | Lowe C R | Diagnostic device |
FI832418L (fi) * | 1983-07-01 | 1985-01-02 | Santasalo Sohlberg Ab Oy | Fuktighetsmaetare foer kornigt material, speciellt foer saed. |
US4672024A (en) * | 1984-04-18 | 1987-06-09 | General Electric Company | Immunological detection device and method for its preparation |
US4647544A (en) * | 1984-06-25 | 1987-03-03 | Nicoli David F | Immunoassay using optical interference detection |
US4563417A (en) * | 1984-08-31 | 1986-01-07 | Miles Laboratories, Inc. | Nucleic acid hybridization assay employing antibodies to intercalation complexes |
GB8423204D0 (en) * | 1984-09-14 | 1984-10-17 | Comtech Res Unit | Assay technique and equipment |
EP0245206A1 (en) * | 1986-05-05 | 1987-11-11 | IntraCel Corporation | Analytical method for detecting and measuring specifically sequenced nucleic acid |
CA1305921C (en) * | 1987-01-30 | 1992-08-04 | Eric K. Gustafson | Diffraction immunoassay and reagents |
-
1988
- 1988-07-07 US US07/216,691 patent/US5089387A/en not_active Expired - Fee Related
-
1989
- 1989-07-06 JP JP1173154A patent/JPH02118437A/ja active Pending
- 1989-07-06 IL IL90893A patent/IL90893A0/xx unknown
- 1989-07-07 AU AU37932/89A patent/AU3793289A/en not_active Abandoned
- 1989-07-07 EP EP19890112493 patent/EP0350073A3/en not_active Withdrawn
- 1989-07-07 CA CA000605154A patent/CA1339117C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0350073A3 (en) | 1991-09-04 |
EP0350073A2 (en) | 1990-01-10 |
JPH02118437A (ja) | 1990-05-02 |
US5089387A (en) | 1992-02-18 |
AU3793289A (en) | 1990-01-11 |
CA1339117C (en) | 1997-07-29 |
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