IL89699A0 - 3-(substituted)-1-carba(dethia)-3-cephems and cephalosporins and a process for production thereof - Google Patents
3-(substituted)-1-carba(dethia)-3-cephems and cephalosporins and a process for production thereofInfo
- Publication number
- IL89699A0 IL89699A0 IL89699A IL8969989A IL89699A0 IL 89699 A0 IL89699 A0 IL 89699A0 IL 89699 A IL89699 A IL 89699A IL 8969989 A IL8969989 A IL 8969989A IL 89699 A0 IL89699 A0 IL 89699A0
- Authority
- IL
- Israel
- Prior art keywords
- dethia
- carba
- substituted
- cephems
- cephalosporins
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 4
- 229940124587 cephalosporin Drugs 0.000 title abstract 4
- 150000001780 cephalosporins Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- -1 sulfonyloxy ester Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/02—Preparation
- C07D463/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/172,091 US4855418A (en) | 1988-03-23 | 1988-03-23 | Process for production of ceophalosporins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL89699A0 true IL89699A0 (en) | 1989-09-28 |
Family
ID=22626323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL89699A IL89699A0 (en) | 1988-03-23 | 1989-03-21 | 3-(substituted)-1-carba(dethia)-3-cephems and cephalosporins and a process for production thereof |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4855418A (de) |
| EP (2) | EP0677523A1 (de) |
| JP (1) | JPH024788A (de) |
| KR (1) | KR890014557A (de) |
| AT (1) | ATE202780T1 (de) |
| CA (1) | CA1338571C (de) |
| DE (1) | DE68929310T2 (de) |
| ES (1) | ES2157884T3 (de) |
| GR (1) | GR3036781T3 (de) |
| HU (1) | HU208014B (de) |
| IL (1) | IL89699A0 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5128336A (en) * | 1988-03-23 | 1992-07-07 | Eli Lilly And Company | 3-(substituted)-1-carba(dethia)-3-cephems |
| US5245027A (en) * | 1989-11-21 | 1993-09-14 | Bristol-Myers Squibb Company | 3-fluorosulfonyloxyceph-3-em compounds |
| US5043439A (en) * | 1990-03-08 | 1991-08-27 | Bristol-Myers Squibb Company | Process for production of cephalosporins |
| DE4030706A1 (de) * | 1990-09-28 | 1992-04-02 | Bayer Ag | Neue 3-substituierte cephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US5106842A (en) * | 1990-10-22 | 1992-04-21 | Bristol-Myers Squibb Co. | Antibiotic c-3 cyclobutenedione substituted (1-carba)cephalosporin compounds, compositions, and methods of use thereof |
| US5604222A (en) * | 1993-12-27 | 1997-02-18 | Lupin Laboratories, Ltd. | Method for the preparation of 2-chloro sulfinyl azetidinones |
| US5578721A (en) * | 1994-07-11 | 1996-11-26 | Lupin Laboratories Limited | Process for preparation of 3-exomethylene cepham sulfoxide esters |
| KR20100093532A (ko) * | 2007-10-25 | 2010-08-25 | 아카오젠, 인코포레이티드 | 카바세펨 β―락탐 항생제 |
| WO2010030810A1 (en) * | 2008-09-10 | 2010-03-18 | Achaogen, Inc. | Carbacephem beta-lactam antibiotics |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0112481A1 (de) * | 1982-11-12 | 1984-07-04 | Kyowa Hakko Kogyo Co., Ltd | Beta-Lactam-Verbindung |
| US4665171A (en) | 1985-07-17 | 1987-05-12 | Harvard University | Process and intermediates for β-lactam antibiotics |
| US4673737A (en) * | 1985-08-02 | 1987-06-16 | Harvard University | 7-acylamino-(or 7-amino)-3-trifluoromethylsulfonyloxy-1-carba(1-dethia)-3-cephem-4-carboxylic acids and esters thereof |
-
1988
- 1988-03-23 US US07/172,091 patent/US4855418A/en not_active Expired - Lifetime
-
1989
- 1989-03-21 IL IL89699A patent/IL89699A0/xx not_active IP Right Cessation
- 1989-03-21 DE DE68929310T patent/DE68929310T2/de not_active Expired - Fee Related
- 1989-03-21 EP EP95201529A patent/EP0677523A1/de not_active Ceased
- 1989-03-21 EP EP89302773A patent/EP0334590B1/de not_active Expired - Lifetime
- 1989-03-21 AT AT89302773T patent/ATE202780T1/de not_active IP Right Cessation
- 1989-03-21 CA CA000594273A patent/CA1338571C/en not_active Expired - Fee Related
- 1989-03-21 ES ES89302773T patent/ES2157884T3/es not_active Expired - Lifetime
- 1989-03-22 KR KR1019890003592A patent/KR890014557A/ko not_active Ceased
- 1989-03-22 HU HU891400A patent/HU208014B/hu not_active IP Right Cessation
- 1989-03-23 JP JP1073698A patent/JPH024788A/ja active Pending
-
2001
- 2001-10-03 GR GR20010401642T patent/GR3036781T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HUT49888A (en) | 1989-11-28 |
| JPH024788A (ja) | 1990-01-09 |
| CA1338571C (en) | 1996-09-03 |
| KR890014557A (ko) | 1989-10-24 |
| US4855418A (en) | 1989-08-08 |
| EP0334590A3 (de) | 1991-07-24 |
| ATE202780T1 (de) | 2001-07-15 |
| DE68929310D1 (de) | 2001-08-09 |
| EP0677523A1 (de) | 1995-10-18 |
| DE68929310T2 (de) | 2002-05-02 |
| EP0334590B1 (de) | 2001-07-04 |
| GR3036781T3 (en) | 2002-01-31 |
| ES2157884T3 (es) | 2001-09-01 |
| EP0334590A2 (de) | 1989-09-27 |
| HU208014B (en) | 1993-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| RH1 | Patent not in force |