IL84658A0 - Pyrrole derivatives,their preparation and pharmaceutical compositions containing the same - Google Patents
Pyrrole derivatives,their preparation and pharmaceutical compositions containing the sameInfo
- Publication number
- IL84658A0 IL84658A0 IL84658A IL8465887A IL84658A0 IL 84658 A0 IL84658 A0 IL 84658A0 IL 84658 A IL84658 A IL 84658A IL 8465887 A IL8465887 A IL 8465887A IL 84658 A0 IL84658 A0 IL 84658A0
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- pyrrolidinyl
- substituted
- piperidyl
- piperazinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Rolls And Other Rotary Bodies (AREA)
- Indole Compounds (AREA)
- Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Derivatives of formula (I), in which A forms with the pyrrole ring an isoindoline, 6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine, 2,3,6,7- tetrahydro-5H-oxathiinno[1,4][2,3C]pyrrole or 2,3,6,7-tetrahydro-5H- dithiinno[1,4][2,3C]pyrrole nucleus and Het = naphthyridinyl, pyridyl or quinolyl which are unsubstituted or substituted by a halogen, alkyl (1-4 C), alkoxy (1-4 C), alkylthio (1-4 C) or CF3, and R = alkenyl (3- 10 C) with a straight or branched chain or alkyl which is unsubstituted or substituted by alkoxy, alkylthio, cycloalkyl (3-6 C), NH2, alkylamino, dialkylamino, alkylcarbonylamino (in which the amino part is optionally alkyl-substituted), 1- or 2-piperazinyl, piperidyl, piperidino, morpholino, pyrrolidinyl, 1-azetidinyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, (1-piperazinyl)carbonyl, piperidinocarbonyl, (1-pyrrolidinyl)carbonyl, phenyl, pyridyl, 1- imidazolyl, or else R = 2- or 3-pyrrolidinyl or 2-,3- or 4-piperidyl, it being understood that the alkyl radicals form a straight or branched chain and, unless specially mentioned, contain 1 to 10 C and that the piperazinyl, piperidino, piperidyl, pyrrolidinyl and azetidinyl radicals may be unsubstituted or substituted in any position by alkyl, alkylcarbonyl, benzyl or hydroxyalkyl or else may form a lactam functional group with the nitrogen atom of the ring, and, when they exist, their pharmaceutically acceptable salts and the optical isomers of the products of formula (I). <IMAGE> The products of formula (I) are useful as anxiolytics.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8616796A FR2607504B1 (en) | 1986-12-02 | 1986-12-02 | NOVEL ISOINDOLINONE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL84658A0 true IL84658A0 (en) | 1988-04-29 |
| IL84658A IL84658A (en) | 1992-01-15 |
Family
ID=9341443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL84658A IL84658A (en) | 1986-12-02 | 1987-11-29 | Esters of 3-hydroxy-2-heteroaryl substituted bicyclic pyrrol-1-one derivatives,their preparation and pharmaceutical compositions containing the same |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0271404B1 (en) |
| JP (1) | JPS63154682A (en) |
| KR (1) | KR880007517A (en) |
| AT (1) | ATE66219T1 (en) |
| AU (1) | AU594215B2 (en) |
| CA (1) | CA1298295C (en) |
| DE (1) | DE3772172D1 (en) |
| DK (1) | DK169969B1 (en) |
| ES (1) | ES2038687T3 (en) |
| FI (1) | FI84723C (en) |
| FR (1) | FR2607504B1 (en) |
| GR (1) | GR3002490T3 (en) |
| HU (1) | HU197573B (en) |
| IE (1) | IE61089B1 (en) |
| IL (1) | IL84658A (en) |
| MA (1) | MA21118A1 (en) |
| MX (1) | MX9558A (en) |
| NO (1) | NO166037C (en) |
| NZ (1) | NZ222752A (en) |
| OA (1) | OA08696A (en) |
| PT (1) | PT86261B (en) |
| SU (3) | SU1616515A3 (en) |
| ZA (1) | ZA879001B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2607503B1 (en) * | 1986-12-02 | 1989-02-24 | Rhone Poulenc Sante | NOVEL ISOINDOLINONE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| FR2607506B1 (en) * | 1986-12-02 | 1989-01-06 | Rhone Poulenc Sante | NOVEL ISOINDOLINONE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| CZ309617B6 (en) * | 2019-04-05 | 2023-05-24 | Ústav organické chemie a biochemie AV ČR, v. v. i | 3α5ß-Neuroactive steroids for the treatment of epilepsy and seizure disorders |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2101081B1 (en) * | 1970-08-19 | 1974-01-11 | Rhone Poulenc Sa | |
| OA04285A (en) * | 1972-01-07 | 1979-12-31 | Rhone Poulenc Sa | New derivatives of pyrrolo (3,4-b) pyrazine and their preparation. |
| AR207555A1 (en) * | 1972-12-04 | 1976-10-15 | PROCEDURE TO PREPARE ARIL-6-PIPERAZINOCARBONYLOXY-5 OXO-7-TETRAHYDRO-2,3,6,7 DITIINE (1,4) (2,3-C) PYRROLES | |
| AR208414A1 (en) * | 1974-11-07 | 1976-12-27 | Rhone Poulenc Ind | PROCEDURE TO OBTAIN NEW DERIVATIVES OF ((ACIL-4PIPERAZINIL-1) CARBONYLOXI-5 PYRROLINONE-2) |
| ZA756953B (en) * | 1974-11-07 | 1976-10-27 | Rhone Poulenc Ind | 1,4-oxathiino(2,3-c)pyrrole derivatives |
| US4590189A (en) * | 1982-04-02 | 1986-05-20 | Takeda Chemical Industries, Ltd. | Condensed pyrrolinone derivatives, their production and use |
| FR2559484B2 (en) * | 1983-07-06 | 1986-09-26 | Provesan Sa | NEW DERIVATIVE 7- (PYRROL-1-YL) OF 1-ETHYL-1,4-DIHYDRO-4-OXO- (1,8-NAPHTYRIDIN) -3-CARBOXYLIC ACID, ITS PREPARATION AND ITS APPLICATION AS A MEDICAMENT |
| CS274601B2 (en) * | 1983-07-27 | 1991-09-15 | Dainippon Pharmaceutical Co | Method of 1,8-naphthyridine derivative production |
| JPS6169773A (en) * | 1984-09-14 | 1986-04-10 | Takeda Chem Ind Ltd | Isoindolinone derivative |
| US4657913A (en) * | 1985-04-18 | 1987-04-14 | Warner-Lambert Company | Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents |
| FR2607503B1 (en) * | 1986-12-02 | 1989-02-24 | Rhone Poulenc Sante | NOVEL ISOINDOLINONE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| FR2607506B1 (en) * | 1986-12-02 | 1989-01-06 | Rhone Poulenc Sante | NOVEL ISOINDOLINONE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
-
1986
- 1986-12-02 FR FR8616796A patent/FR2607504B1/en not_active Expired
-
1987
- 1987-11-27 MA MA21359A patent/MA21118A1/en unknown
- 1987-11-29 IL IL84658A patent/IL84658A/en unknown
- 1987-11-30 IE IE325287A patent/IE61089B1/en not_active IP Right Cessation
- 1987-11-30 AU AU81936/87A patent/AU594215B2/en not_active Ceased
- 1987-11-30 ZA ZA879001A patent/ZA879001B/en unknown
- 1987-11-30 NZ NZ222752A patent/NZ222752A/en unknown
- 1987-12-01 MX MX955887A patent/MX9558A/en unknown
- 1987-12-01 HU HU875398A patent/HU197573B/en not_active IP Right Cessation
- 1987-12-01 CA CA000553252A patent/CA1298295C/en not_active Expired - Lifetime
- 1987-12-01 DE DE8787402708T patent/DE3772172D1/en not_active Expired - Fee Related
- 1987-12-01 FI FI875299A patent/FI84723C/en not_active IP Right Cessation
- 1987-12-01 EP EP87402708A patent/EP0271404B1/en not_active Expired - Lifetime
- 1987-12-01 ES ES198787402708T patent/ES2038687T3/en not_active Expired - Lifetime
- 1987-12-01 NO NO875012A patent/NO166037C/en unknown
- 1987-12-01 KR KR870013649A patent/KR880007517A/en not_active Application Discontinuation
- 1987-12-01 SU SU874203799A patent/SU1616515A3/en active
- 1987-12-01 DK DK630487A patent/DK169969B1/en not_active IP Right Cessation
- 1987-12-01 AT AT87402708T patent/ATE66219T1/en not_active IP Right Cessation
- 1987-12-02 PT PT86261A patent/PT86261B/en not_active IP Right Cessation
- 1987-12-02 JP JP62305512A patent/JPS63154682A/en active Pending
- 1987-12-02 OA OA59236A patent/OA08696A/en unknown
-
1988
- 1988-11-04 SU SU884356916A patent/SU1657056A3/en active
- 1988-11-04 SU SU884356873A patent/SU1685264A3/en active
-
1991
- 1991-08-16 GR GR91400274T patent/GR3002490T3/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL84657A0 (en) | Pyrrole derivatives,their preparation and pharmaceutical compositions containing the same | |
| AU594215B2 (en) | New pyrrole derivatives, their preparation and pharmaceutical compositions which contain them | |
| AU594538B2 (en) | New pyrrole derivatives, their preparation and pharmaceutical compositions which contain them |