IL80176A0 - 1-methyl-15alpha-alkylandrosta-1,4-diene-3,17-dione derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same - Google Patents
1-methyl-15alpha-alkylandrosta-1,4-diene-3,17-dione derivatives,processes for the preparation thereof and pharmaceutical compositions containing the sameInfo
- Publication number
- IL80176A0 IL80176A0 IL80176A IL8017686A IL80176A0 IL 80176 A0 IL80176 A0 IL 80176A0 IL 80176 A IL80176 A IL 80176A IL 8017686 A IL8017686 A IL 8017686A IL 80176 A0 IL80176 A0 IL 80176A0
- Authority
- IL
- Israel
- Prior art keywords
- alkylandrosta
- 15alpha
- diene
- methyl
- processes
- Prior art date
Links
- OSVMTWJCGUFAOD-KZQROQTASA-N formestane Chemical class O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1O OSVMTWJCGUFAOD-KZQROQTASA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1. m¢ethyl-15alpha-alkylandrosta-1,4-dienes-3,17-diones of the general formula I see diagramm : EP0225272,P12,F1 in which R15 is an alkyl group of 1 to 4 carbon atoms, which may be substituted in the 1 and/or 2 position by a hydroxy or a C2 -C7 alkanoyloxy group or a 1,2-isopropylidenedioxy group.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853539244 DE3539244A1 (en) | 1985-11-01 | 1985-11-01 | 1-METHYL-15 (ALPHA) -ALKYL-ANDROSTA- 1,4-DIEN-3,17-DIONE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL80176A0 true IL80176A0 (en) | 1986-12-31 |
Family
ID=6285220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL80176A IL80176A0 (en) | 1985-11-01 | 1986-09-29 | 1-methyl-15alpha-alkylandrosta-1,4-diene-3,17-dione derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0225272B1 (en) |
| JP (1) | JPS62155294A (en) |
| CN (1) | CN86107158A (en) |
| AT (1) | ATE41936T1 (en) |
| AU (1) | AU6432986A (en) |
| DD (1) | DD250319A5 (en) |
| DE (2) | DE3539244A1 (en) |
| DK (1) | DK515486A (en) |
| FI (1) | FI864329A7 (en) |
| GR (1) | GR880300115T1 (en) |
| HU (1) | HU196079B (en) |
| IL (1) | IL80176A0 (en) |
| NO (1) | NO864365L (en) |
| NZ (1) | NZ218071A (en) |
| PT (1) | PT83659B (en) |
| ZA (1) | ZA868333B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3703722A1 (en) * | 1987-02-04 | 1988-08-18 | Schering Ag | 1-METHYL-15 (ALPHA) - (1,2-DIALKANOYLOXYALKYL) -ANDROSTA-1,4-DIEN-3,17-DIONE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM |
| DE3705990A1 (en) * | 1987-02-20 | 1988-09-01 | Schering Ag | 1-METHYL-15 (ALPHA) - (1-OXYALKYL) -ANDROSTA-1,4-DIEN-3,17-DIONE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM |
| DE3715869A1 (en) * | 1987-05-07 | 1988-11-17 | Schering Ag | METHOD FOR PRODUCING 1-METHYL-ANDROSTA-1,4-DIEN-3,17-DION AND THE NEW INTERMEDIATE PRODUCTS FOR THIS METHOD |
| CH683151A5 (en) * | 1991-04-24 | 1994-01-31 | Ciba Geigy Ag | Contraception in female primates without affecting the menstrual cycle. |
| DE4435368A1 (en) * | 1994-09-22 | 1996-03-28 | Schering Ag | Use of aromatase inhibitors for the manufacture of a medicament for the treatment of a relative androgen deficiency in men |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3766224A (en) * | 1971-06-03 | 1973-10-16 | Sandoz Ag | 15-methyl-substituted steroids |
| DE3322285A1 (en) * | 1983-06-18 | 1984-12-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | 1-ALKYL-ANDROSTA-1,4-DIEN-3,17-DIONE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM |
-
1985
- 1985-11-01 DE DE19853539244 patent/DE3539244A1/en not_active Withdrawn
-
1986
- 1986-09-29 IL IL80176A patent/IL80176A0/en unknown
- 1986-10-23 AU AU64329/86A patent/AU6432986A/en not_active Abandoned
- 1986-10-24 FI FI864329A patent/FI864329A7/en not_active Application Discontinuation
- 1986-10-28 DK DK515486A patent/DK515486A/en not_active Application Discontinuation
- 1986-10-28 NZ NZ218071A patent/NZ218071A/en unknown
- 1986-10-29 DE DE8686730177T patent/DE3662693D1/en not_active Expired
- 1986-10-29 EP EP86730177A patent/EP0225272B1/en not_active Expired
- 1986-10-29 AT AT86730177T patent/ATE41936T1/en not_active IP Right Cessation
- 1986-10-30 DD DD86295752A patent/DD250319A5/en unknown
- 1986-10-31 HU HU864575A patent/HU196079B/en not_active IP Right Cessation
- 1986-10-31 PT PT83659A patent/PT83659B/en unknown
- 1986-10-31 JP JP61258659A patent/JPS62155294A/en active Pending
- 1986-10-31 ZA ZA868333A patent/ZA868333B/en unknown
- 1986-10-31 NO NO864365A patent/NO864365L/en unknown
- 1986-11-01 CN CN198686107158A patent/CN86107158A/en active Pending
-
1989
- 1989-06-22 GR GR88300115T patent/GR880300115T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0225272A1 (en) | 1987-06-10 |
| ATE41936T1 (en) | 1989-04-15 |
| JPS62155294A (en) | 1987-07-10 |
| PT83659A (en) | 1986-11-01 |
| NO864365L (en) | 1987-05-04 |
| NZ218071A (en) | 1989-01-06 |
| DE3662693D1 (en) | 1989-05-11 |
| CN86107158A (en) | 1987-08-05 |
| FI864329A7 (en) | 1987-05-02 |
| FI864329A0 (en) | 1986-10-24 |
| DD250319A5 (en) | 1987-10-08 |
| DK515486A (en) | 1987-05-02 |
| GR880300115T1 (en) | 1989-06-22 |
| EP0225272B1 (en) | 1989-04-05 |
| HUT43618A (en) | 1987-11-30 |
| NO864365D0 (en) | 1986-10-31 |
| ZA868333B (en) | 1987-06-24 |
| HU196079B (en) | 1988-09-28 |
| AU6432986A (en) | 1987-05-07 |
| DK515486D0 (en) | 1986-10-28 |
| PT83659B (en) | 1988-08-30 |
| DE3539244A1 (en) | 1987-05-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK94190A (en) | Substituted androsta-1,4-diene-3,17-diones and process for their preparation | |
| DE3570038D1 (en) | Steroids for use as immunomodulators | |
| WO1988000042A1 (en) | New 5-alkoxy-2,4-diamino-alkyl benzols, and hair tinting means using them | |
| AU5936386A (en) | Diamino-androstane derivatives, process for their preparation and pharmaceutical compositions containing them | |
| AU4700389A (en) | Phosphonic acid substituted steroids as steroid 5alpha- reductase inhibitors | |
| AU579497B2 (en) | Peptic ulcer treatment method | |
| IL80176A0 (en) | 1-methyl-15alpha-alkylandrosta-1,4-diene-3,17-dione derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same | |
| TW336235B (en) | 3'-aziridino-anthracycline derivatives, process for preparating them and pharmaceutical composition containing them | |
| EP0385446A3 (en) | Osteogenesis promotion with use of vitamin d derivatives | |
| DE3563971D1 (en) | 1-alpha, 2-alpha-methylene-6-methylene and 6-alpha-methyl pregnenes, process for their preparation and pharmaceutical compositions containing them | |
| ZA933993B (en) | Novel estradiol derivative-chlorambucil conjugate, process for preparing the same, and pharmaceutical composition. | |
| DE3571441D1 (en) | Process for the preparation of pregnane derivative | |
| AU5847386A (en) | Derivatives of 1,1,2,2-tetramethyl-1,2-bis-(2-fluoro-4- hydroxphenyl)-ethane | |
| IE34308L (en) | 11ß, 13ß-DIALKYLGONA-1,3,5(10)-TRIEN-3-OL 3-CYCLOALKYL¹ETHERS | |
| AU584098B2 (en) | Substituted azabicycloheptanes, the use thereof, pharmaceutical preparations that contain these compounds, and processes for the manufacture of these compounds | |
| EP0296979A3 (en) | 1-benzoyl-2-oxo-5-alkoxy-pyrrolidine derivatives, their preparation, their use and preparations containing them | |
| EP0139907A3 (en) | Estrane derivatives | |
| JPS5268196A (en) | Bicyclomycin derivatives | |
| IL67323A0 (en) | New dehydrocardenolide derivatives,process for the preparation thereof and pharmaceutical preparations containing the same | |
| IE872998L (en) | 4-hydroxy-4-(substituted alkenyl)- cyclohexanecarboxylic¹acids | |
| KR910000786A (en) | Cholesadiene derivatives, methods for their preparation and their use as agents for inhibiting HMG-CoA reducing agents |